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Flexerin
Somatec Pharmaceuticals Ltd.
Generic: Cyclobenzaprine Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
Flexerin may cause excessive drowsiness with alcohol.
SAFE IF PRESCRIBED
Flexerin is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
CONSULT YOUR DOCTOR
Flexerin is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Flexerin may cause side effects which could affect your ability to drive.
CONSULT YOUR DOCTOR
There is limited information available on the use of Flexerin in patients with kidney disease. Please consult your doctor.
CAUTION
Flexerin should be used with caution in patients with liver disease. Dose adjustment of Flexerin may be needed. Please consult your doctor.
Use of Flexerin is not recommended in patients with moderate to severe liver disease.
Medicine Overview of Flexerin 10mg Tablet
Introduction
Flexerin is a muscle relaxer. It provides relief from the discomfort associated with acute, painful musculoskeletal conditions such as rigidity, tension, stiffness, and muscle spasms. Flexerin should be taken with food. This will prevent you from getting an upset stomach. In general, you should try to use the smallest amount necessary to control your symptoms, for the shortest possible time. You should take this medicine regularly while you need it. Try not to miss doses as this will make the medicine less effective. Some common side effects of this medicine include sleepiness, dryness in mouth, tiredness, and headache. If any...
... Show moreUses of Flexerin
- Muscle relaxation
Side effects of Flexerin
Common
- Sleepiness
- Dryness in mouth
How to use Flexerin
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Flexerin is to be taken with food.
How Flexerin works
Flexerin is a muscle relaxant. It works on the centres in the brain and spinal cord to relieve muscle stiffness or spasm without reduction in strength. This improves pain and movement of muscles.
What if you forget to take Flexerin?
If you miss a dose of Flexerin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Skelebenz 15 Capsule ER provides relief from rigidity, tension and stiffness in muscles (spasticity) that may occur due to various conditions affecting the nervous system.
- Take it with or after food or a glass of milk.
- Skelebenz 15 Capsule ER may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- Avoid consuming alcohol when taking Skelebenz 15 Capsule ER as it may cause excessive drowsiness.
- Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
- Do not stop taking it suddenly without talking to your doctor if you've been on it for a long time.
Brief Description
Indication
Fibromyalgia, Muscle spasm
Adult Dose
Oral
Painful muscle spasm associated with musculoskeletal conditions
Adult: 5 mg tid, may increase to 10 mg tid if needed. Treatment should not last more than 2-3 wk. Max: 60 mg.
Elderly: Initiate with 5 mg with less frequent dosing.
Max Dosage: 60 mg.
Hepatic impairment: MIld: Start with 5 mg dose with less frequent dosing. Moderate to severe: Not recommended.
Child Dose
Muscle Spasm
Oral
15 years: 5 mg PO q8hr; may increase dose to 10 mg PO q8hr PRN
Contraindication
Recent MI, arrhythmias, severe liver disease.
Mode of Action
Cyclobenzaprine, a centrally-acting skeletal muscle relaxant, is structurally related to tricyclic antidepressants, thus they share similar properties. It acts on the brain stem, decreasing tonic-somatic motor activities influencing both the ? and ? motor systems. It is used as an adjunct in the symptomatic treatment of painful muscle spasms associated with musculoskeletal conditions.
Precaution
Cardiac disease, history of epilepsy, hepatic impairment, hyperthyroidism, pheochromocytoma, history of mania, psychoses, close-angle glaucoma, history of urinary retention, concurrent electroconvulsive therapy, diabetes. Pregnancy and lactation; elderly, child. Unsafe for use in patients with porphyria. Avoid abrupt withdrawal. May cause drowsiness; do not drive or operate machinery. Treatment for more than 2-3 wk is not recommended.
Lactation: Excretion in milk unknown; use with caution
Side Effect
>10%
Drowsiness (up to 39% immediate-release),Dry mouth (21-32%),Dizziness (3-11%)
1-10%
Pharyngitis (1-3%),Headache (1-5%),Fatigue (6%),Palpitations (6%),Bad taste in mouth (1-6%),Indigestion (4%),Blurred vision (3%),Constipation (1-3%),Asthenia (1-3%),Confusion (1-3%),Nausea (1-3%),Nervousness (1-3%)
<1%
Arrhythmia,Hypotension,Palpitation,Syncope,Tachycardia,Vasodilation,Cardiac dysrhythmia (rare),Cholestasis (rare),Hepatitis,Jaundice,Anaphylaxis (rare),Immune hypersensitivity reaction
Pregnancy Category Note
Pregnancy
Available data from case reports with use in pregnancy have not identified a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes
Lactation
There are no data on presence of drug in either human or animal milk, the effects on a breastfed infant, or effects on milk production; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed child from therapy or from underlying maternal condition.
Interaction
Plasma concentration may be increased with the use of cimetidine, diltiazem, disulfiram, methylphenidate, ritonavir, and verapamil. Side-effects are increased by adrenaline, amiodarone, general anesthetics, SSRIs, antihistamines, antimuscarinics, antipsychotics, anxiolytics and hypnotics, clozapine, disopyramide, diuretics, flecainide, MAOIs, moclobemide, moxifloxacin, nefopam, nicorandil, noradrenaline, phenothiazine, pimozide, procainamide, propafenone, quinidine, selegiline, sibutramine, sotalol, terfenadine, thioridazine, and tramadol. Effects of adrenergic neurone blockers, clonidine, barbiturates, nitrates, and primidone are reduced while effects of baclofen, opioid analgesics, and thyroid hormones are enhanced with concomitant use of cyclobenzaprine. Carbamazepine and rifampicin may increase metabolism of cyclobenzaprine. Effects may be antagonized by oestrogens. Avoid use with brimonidine, entacapone,...
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