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Flexifen 25
Incepta Pharmaceuticals Ltd.
Generic: Baclofen
Safety Advices
বাংলা
English
UNSAFE
Flexifen 25 may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Flexifen 25 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Flexifen 25 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Flexifen 25 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Flexifen 25 should be used with caution in patients with kidney disease. Dose adjustment of Flexifen 25 may be needed. Please consult your doctor.
CAUTION
Flexifen 25 should be used with caution in patients with liver disease. Dose adjustment of Flexifen 25 may be needed. Please consult your doctor.
Medicine Overview of Flexifen 25mg Tablet
Introduction
Flexifen 25 is a muscle relaxer. It is used to treat muscle symptoms such as rigidity, tension, and stiffness that may occur due to various conditions such as cerebral palsy, multiple sclerosis, motor neuron disease, or injury to the head, brain or spine. Flexifen 25 can be taken with food. In general, you should try to use the smallest amount necessary to control your symptoms, for the shortest possible time. You should take this medicine regularly while you need it. Try not to miss doses as this will make the medicine less effective. Some common side effects of this medicine...
... Show moreUses of Flexifen 25
- Muscle relaxation
Side effects of Flexifen 25
Common
- Fatigue
- Weakness
- Drowsiness
- Dizziness
How to use Flexifen 25
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Flexifen 25 is to be taken with food.
How Flexifen 25 works
Flexifen 25 is a muscle relaxant. It works on the brain and spinal cord to relieve muscle stiffness or spasm maintaining the strength of the muscles. This relieves pain and improves movement of muscles.
What if you forget to take Flexifen 25?
If you miss a dose of Flexifen 25, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Flexifen 25 provides relief from rigidity, tension and stiffness in muscles (spasticity) that may occur due to various conditions affecting the nervous system.
- Take it with or after food or a glass of milk.
- Flexifen 25 may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- Avoid consuming alcohol when taking Flexifen 25 as it may cause excessive drowsiness.
- Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
- Do not stop taking it suddenly without talking to your doctor if you've been on it for a long time.
Brief Description
Indication
Pain, Chronic muscle spasticity, Multiple sclerosis, Spasm, Stiffness, Low back pain
Administration
Should be taken with food.
Adult Dose
Oral
Spasticity
Adult: Initially, 5 mg tid for 3 days increased to 10 mg tid for 3 days, then in similar increments and intervals until either 20 mg tid is reached or until desired effect is obtained. Max: 80 mg daily.
Elderly: Initiate with lower doses.
Child Dose
Oral
Spasticity
Child: 0.75-2 mg/kg daily. May initiate with 2.5 mg 4 times daily, increased gradually every 3 days until desired effect is obtained.
Maintenance: 6-10 yr: 30-60 mg daily; 2-6 yr: 20-30 mg daily; 12 mth-2 yr: 10-20 mg daily. Max: >10 yr: 2.5 mg/kg daily.
Renal Dose
Renal impairment: Dose reduction may be required.
Contraindication
Hypersensitivity. Active peptic ulcer disease.
Mode of Action
Baclofen is an antispastic. It inhibits both monosynaptic and polysynaptic reflexes at spinal level.
Precaution
Cerebrovascular disorders, epilepsy, severe psychotic disorders, confusional states, history of peptic ulcer, resp depression, diabetes (DM), hepatic or renal impairment, elderly, pregnancy. Avoid sudden withdrawal.
Lactation: Enters breast milk in small amounts; not recommended
Side Effect
>10%
Drowsiness, transient (10-63%),Dizziness (5-15%),Nausea (4-12%),Confusion (1-11%)
1-10%
Headache (4-8%),Insomnia (2-7%),Constipation (2-6%),Urinary frequency (2-6%),Fatigue (2-4%)
<1%
Abdominal pain,Ankle edema,Anorexia,Ataxia,Blurred vision,Chest pain,Coordination disorder,Depression,Diarrhea,Dry mouth,Diplopia,Dysarthria,Dyspnea,Dystonia,Enuresis,Euphoria,Excitement,Hallucinations,Hematuria,Hypotension,Impotence,Miosis,Muscle pain,Mydriasis,Nasal congestion,Nocturia,Nystagmus,Palpitation,Paresthesia,Excessive perspiration,Pruritus,Rash,Rigidity,Seizure,Strabismus,Slurred speech,Syncope,Tinnitus,Tremor,Urinary retention,Vomiting,Weight gain
Potentially Fatal: Respiratory or CV depression, seizures.
Pregnancy Category Note
Pregnancy There are no adequate data on the developmental risk associated with the use in pregnant women Oral administration of baclofen to pregnant rats resulted in an increased incidence of fetal structural abnormalities at a dose which was also associated with maternal toxicity Clinical considerations May increase the risk of late-onset neonatal withdrawal symptoms Animal data Baclofen given orally has been shown to increase the incidence of omphaloceles (ventral hernias) in fetuses of rats given ~13 times on a mg/kg basis, or 3 times on a mg/m2 basis, the maximum oral dose recommended for human use; this dose also caused...
... Show moreInteraction
Hypotensive effect may be increased with antihypertensives. Concomittant use with levodopa in Parkinson patients may result in confusion, agitation, hallucinations.
Potentially Fatal: CNS depressants and alcohol may potentiate CNS effects.
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