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Thiocil 50
Incepta Pharmaceuticals Ltd.
Generic: Propylthiouracil
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Thiocil 50. Please consult your doctor.
CONSULT YOUR DOCTOR
Thiocil 50 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Thiocil 50 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
The American Thyroid Association also recommends monitoring babies for appropriate growth and development during routine pediatric check-ups.
CONSULT YOUR DOCTOR
It is not known whether Thiocil 50 alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
SAFE IF PRESCRIBED
Thiocil 50 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Thiocil 50 may not be needed in these patients. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Thiocil 50 in patients with liver disease. Please consult your doctor.
Medicine Overview of Thiocil 50mg tablet
Introduction
Thiocil 50 belongs to a group of medicine called anti-thyroid agents. It is used in the treatment of hyperthyroidism. It works by reducing the production of a hormone called thyroxine by the thyroid gland. Thiocil 50 may be used alone or in combination with other medicines. It can be taken with or without food. It should be taken exactly as prescribed by your doctor. Your doctor will decide the dose and how often you should take them. You should take this medicine regularly to get the most benefit from it. Do not stop taking the medicine even if you feel...
... Show moreUses of Thiocil 50
- Hyperthyroidism
Side effects of Thiocil 50
Common
- Skin rash
- Hair loss
- Headache
- Pain
- Joint stiffness
- Nausea
- Skin pigmentation
- Paresthesia (tingling or pricking sensation)
How to use Thiocil 50
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Thiocil 50 may be taken with or without food, but it is better to take it at a fixed time.
How Thiocil 50 works
Thiocil 50 is an anti-thyroid medication. It works by reducing the amount of thyroid hormones produced by the thyroid gland.
Quick Tips
- PTU Tablet is used for the treatment of hyperthyroidism.
- You may have to stop taking it for a while if you are also taking radio-iodine as a treatment for your overactive thyroid.
- It may affect the level of blood cells in your blood. Inform your doctor if you experience symptoms such as unexplained bruising or bleeding, sore throat, mouth ulcers, fever, or general illness.
- Stop taking PTU Tablet and Inform your doctor if you develop symptoms of liver damage such as abdominal pain, loss of appetite, darkened urine or yellowing of the eyes or skin.
- Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.
Brief Description
Indication
Hyperthyroidism
Administration
Should be taken with food.
Adult Dose
Oral
Hyperthyroidism
Adult: 150-450 mg daily in divided doses. For severe cases, initial doses of 600-1200 mg daily have been used. Maintenance dose for euthyroid patients: 50-150 mg daily. Treatment is usually continued for 1-2 yr.
Hepatic impairment: Dose reduction is recommended.
Child Dose
Oral
Hyperthyroidism
Child: Neonates: 2.5-5 mg/kg bid; 1 mth-1 yr: 2.5 mg/kg tid; 1-5 yr: 25 mg tid; 5-12 yr: 50 mg tid; 12-18 yr: 100 mg tid.
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<10 Reduce dose by 50%.
10-50 Reduce dose by 25%.
Contraindication
Hypersensitivity, pregnancy, lactation.
Mode of Action
Propylthiouracil inhibits the production of thyroid hormones by preventing iodine from being oxidised in the thyroid gland. It also blocks the peripheral deiodination of thyroxine to tri-iodothyronine.
Precaution
Reserve use for patients unable to tolerate any other treatments e.g. methimazole, radioactive iodine or surgery. Inform patient of liver failure risk and to report any signs of liver dysfunction (e.g. loss of appetite, nausea, vomiting, pruritus, dark coloured urine, light coloured stools, jaundice, right upper-quadrant pain) or agranulocytosis (e.g. fever, sore throat) immediately. Stop treatment upon signs of agranulocytosis, aplastic anaemia, fever, liver injury, elevated LFT above 3 times the upper limit of normal, or exfoliative dermatitis. Regular monitoring of thyroid function and CBC is advisable. Monitor prothrombin time regularly during treatment, especially before surgical procedures. Lactation: distributed in...
... Show moreSide Effect
Mild leukopenia, lupus-like syndrome, cutaneous vasculitis, thrombocytopenia. Skin rash, urticaria, arthralgia and fever. GI discomfort, vomiting, headache.
Potentially Fatal: Agranulocytosis, aplastic anaemia, liver injury and liver failure.
Interaction
May potentiate activity of anticoagulants. Doses of β-blockers, digitalis glycosides and theophylline may need to be reduced when patient becomes euthyroid.
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