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Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Ledomide 10. Please consult your doctor.
UNSAFE
Ledomide 10 is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
CONSULT YOUR DOCTOR
Ledomide 10 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Ledomide 10 may cause side effects which could affect your ability to drive.
You may feel dizzy, tired, sleepy, have vertigo or blurred vision after taking Ledomide 10 and this may affect your ability to drive.
CAUTION
Ledomide 10 should be used with caution in patients with kidney disease. Dose adjustment of Ledomide 10 may be needed. Please consult your doctor.
CAUTION
Ledomide 10 should be used with caution in patients with liver disease. Dose adjustment of Ledomide 10 may be needed. Please consult your doctor.
Medicine Overview of Ledomide 10mg capsule
Introduction
Ledomide 10 is used in the treatment of multiple myeloma and lepra reaction. This medicine belongs to a group of medicines which affect how your immune system works. Ledomide 10 can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the...
... Show moreUses of Ledomide 10
- Multiple myeloma
- Lepra reaction
Side effects of Ledomide 10
Common
- Headache
- Weakness
- Nausea
- Rash
- Dizziness
- Sleepiness
- Edema (swelling)
- Loss of appetite
- Decreased white blood cell count
- Decreased calcium level in blood
- Weight gain
- Muscle weakness
- Fatigue
- Fever
- Anxiety
- Blood clots
- Dry skin
- Weight loss
- Confusion
- Decreased white blood cell count (neutrophils)
- Neuropathy
- Constipation
- Tremor
How to use Ledomide 10
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Ledomide 10 may be taken with or without food, but it is better to take it at a fixed time.
How Ledomide 10 works
Ledomide 10 is an anti-cancer medication. It works by enhancing the immune system that indirectly attacks the cancer cells. It prevents the growth of new blood vessels within the tumor. It also restricts the production of chemical messengers (cytokine and growth factor) which are responsible for the growth of cancer cells. This is how it works against cancer.
Quick Tips
- You may be monitored with regular blood tests before and during the treatment as lenalidomide may cause a fall in the white blood cells and platelets, required to fight infection, Hemoglobin and blood clotting.
- Avoid activities that may cause bruising or injury and avoid contact with people who have colds or infections.
- It makes your skin sensitive towards sunlight. Apply sunscreen or wear protective while going out.
- It may cause dehydration. Drink plenty of water to stay hydrated while taking medication.
- It is not recommended for use in children and adolescents under 18 years.
- You should use proper contraceptive methods at least 4 weeks before, during and until 4 weeks after stopping treatment.
- Woman of childbearing potential will be required to undergo pregnancy tests before and after the treatment.
- You should inform your doctor or dentist that you are taking Ledomide 10 before you receive any medical or dental care, emergency care, or surgery.
- It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- You may be at risk of developing acute myelogenous leukemia, Hodgkin lymphoma tumor lysis syndrome, fatal liver problems, severe skin reactions, and fatal heart problems during treatment with Ledomide 10. You should discuss in advance the benefits and risks of taking this medicine.
Brief Description
Indication
Myelodysplastic disease, Multiple myeloma
Administration
May be taken with or without food. Swallow whole, do not break/chew/open.
Adult Dose
Oral
Myelodysplastic disease
Adult: Initially, 10 mg once daily for 21 consecutive days of repeated 28-day cycle.
Multiple myeloma
Adult: In combination w/ dexamethasone.
Lenalidomide: Initially, 25 mg once daily for 21 consecutive days of repeated 28-day cycle.
Dexamethasone: 40 mg once daily on days 1-4, 9-12 and 17-20 of each 28-day cycle, for the 1st 4 cycles, then 40 mg once daily on days 1-4 of each 28-day cycle.
Elderly: No dosage adjustment needed.
Child Dose
<18 years old: Safety and efficacy not established
Renal Dose
Myelodysplastic disease:
Moderate: 5 mg once daily.
Severe (not requiring dialysis): 5 mg every other day.
End-stage renal disease: 5 mg 3 times/wk after dialysis.
Multiple myeloma:
Moderate: 10 mg once daily may be increased to 15 mg once daily after 2 cycles if needed.
Severe (not requiring dialysis): 15 mg every other day, may be increased to 10 mg once daily if needed.
End-stage renal disease: 5 mg once daily after dialysis.
Contraindication
Pregnancy and lactation; sexually active women of childbearing potential not using 2 forms of contraception.
Demonstrated hypersensitivity (eg, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis)
Mode of Action
Lenalidomide, a thalidomide analogue, is an immunomodulatory agent w/ antiangiogenic and antineoplastic property. It inhibits proinflammatory cytokines secretion, increases interleukin-2 and interferon-γ secretion, and increases cytolytic T-cell and natural killer cell response. It also inhibits the growth of myeloma cells by inducing cell cycle arrest and cell death.
Precaution
Potential for human birth defects Analog of thalidomide, a known human teratogen that causes severe, life-threatening human birth defects. Avoid during pregnancy; if taken during pregnancy, likely to cause birth defects or fetal death. Pregnancy test is required prior initiation of therapy and should commence contraceptive measures following negative result. Pregnancy test must be repeated at a regular interval during therapy. History of thrombosis; smokers; patients w/ HTN, hyperlipidaemia, high tumour burden. Renal impairment. Significantly increased risk of deep vein thrombosis (DVT) and pulmonary embolism (PE), as well as risk of myocardial infarction and stroke in patients with multiple myeloma...
... Show moreSide Effect
>10%
Thrombocytopenia (62%),Neutropenia (59%),Diarrhea (48%),Pruritus (42%),Nausea (35%),Rash (35%),Fatigue (31%),Constipation (24%),Arthralgia (22%),Back pain (21%),Peripheral edema (21%),Pyrexia (21%),Dizziness (20%),Headache (20%),Cough (19%),Muscle cramp (18%),Dyspnea (17%),URTI (15%),Anemia (12%),Pneumonia (12%),UTI (11%)
1-10% (critical AEs)
Tumor flare reaction - MCL (10%),Abdominal pain (8%),Leukopenia (8%),Myalgia (8%),Pain (7%),Bronchitis (6%),Rhinitis (6%),Febrile neutropenia (5%),Peripheral neuropathy (5%)
Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, angioedema. Acute hepatic failure; toxic, cytolytic, cholestatic and mixed cytolytic/ cholestatic hepatitis.
Interaction
May increase risk of thrombosis w/ erythropoietic agents. May increase plasma concentration of digoxin, ketoconazole, itraconazole, ciclosporin, verapamil, quinidine, clarithromycin.
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