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Melphalan 50 IV Infusion
Renata Limited
Generic: Melphalan
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Melphalan 50 IV Infusion. Please consult your doctor.
CONSULT YOUR DOCTOR
Melphalan 50 IV Infusion is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Melphalan 50 IV Infusion is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
CONSULT YOUR DOCTOR
It is not known whether Melphalan 50 IV Infusion alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
CAUTION
Melphalan 50 IV Infusion should be used with caution in patients with kidney disease. Dose adjustment of Melphalan 50 IV Infusion may be needed. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Melphalan 50 IV Infusion in patients with liver disease. Please consult your doctor.
Medicine Overview of Melphalan 50 IV Infusion 50mg/vial injection
Introduction
Melphalan 50 IV Infusion is used to treat cancer of ovaries and a type of cancer of bone marrow called multiple myeloma. It may be also used to treat other conditions, as determined by the doctor. Melphalan 50 IV Infusion should be taken on an empty stomach, but try to take it at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has...
... Show moreUses of Melphalan 50 IV Infusion
- Ovarian cancer
- Multiple myeloma
Side effects of Melphalan 50 IV Infusion
Common
- Nausea
- Vomiting
- Stomatitis (Inflammation of the mouth)
- Anemia (low number of red blood cells)
- Hair loss
- Low blood platelets
- Diarrhea
- Decreased white blood cell count
How to use Melphalan 50 IV Infusion
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Melphalan 50 IV Infusion is to be taken empty stomach.
How Melphalan 50 IV Infusion works
Melphalan 50 IV Infusion is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.
What if you forget to take Melphalan 50 IV Infusion?
If you miss a dose of Melphalan 50 IV Infusion, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Melphalan 50 IV Infusion should be taken as per dose and duration suggested by the doctor.
Brief Description
Indication
Breast cancer, Ovarian cancer, Multiple myeloma, Neuroblastoma, Soft tissue sarcoma, Malignant melanoma, Retinoblastoma, Polycythaemia vera
Administration
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Adult Dose
Adult Multiple Myeloma Palliative treatment Indicated for the palliative treatment of patients with MM Oral 6 mg PO qDay for 2-3 weeks, OR 10 mg PO qDay for 7-10 days, OR 0.15 mg/kg/day PO for 7 days, THEN After adequate recovery from toxicity (monitor WBCs and platelets) give 1-3 mg or 0.05 mg/kg PO qDay Intravenous If unable to take oral, may administer IV 16 mg/m² IV as a single infusion over 15-20 minutes q2wk for 4 doses, THEN After adequate recovery from toxicity (monitor WBCs and platelets) administer q4wk Conditioning treatment Indicated for use as a high-dose conditioning treatment...
... Show moreChild Dose
Safety and efficacy not established
Renal Dose
Renal impairment (BUN >30 mg/dL): Consider dosage reduction of up to 50%
Contraindication
Hypersensitivity. Severe bone marrow suppression. Pregnancy.
Mode of Action
Melphalan, a mechlorethamine derivative, is an alkylating antineoplastic agent. It forms carbonium ions, resulting in DNA and RNA synthesis inhibition. It cross-links DNA strands and acts on both resting and rapidly dividing tumour cells.
Precaution
Renal impairment. Lactation. Prior bone marrow suppression, prior chemotherapy or irradiation. May mask signs of infection e.g. fever and increased WBC. Elderly.
Lactation: not known if excreted in breast milk
Side Effect
>10%
Myelosuppression (30%)
Frequency Not Defined
Diarrhoea, stomatitis, vomiting; haemolytic anaemia, vasculitis, pulmonary fibrosis, hepatic disorders, suppression of ovarian function in premenopausal women, temporary or permanent sterility in male patients. Allergic reactions.
Potentially Fatal: Bone marrow suppression. Secondary malignancy, cardiac arrest. Anaphylaxis.
Interaction
Potentially Fatal: Fatal haemorrhagic enterocolitis with concurrent nalidixic acid in children. Potentiates risk of renal damage with ciclosporin.
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