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Leviram 500
DBL Pharmaceuticals Ltd.
Generic: Levetiracetam
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Leviram 500.
CONSULT YOUR DOCTOR
Leviram 500 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Leviram 500 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Monitor the baby for sleepiness and adequate weight gain.
UNSAFE
Leviram 500 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Leviram 500 should be used with caution in patients with kidney disease. Dose adjustment of Leviram 500 may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Leviram 500 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Leviram 500 may not be needed in these patients. Please consult your doctor.
However, a lower dose may be advised in patients with severe liver disease.
Medicine Overview of Leviram 500mg tablet
Introduction
Leviram 500 is an anti-epileptic medicine used to treat seizures (fits) in epilepsy. It can be used alone or along with other medicines. It helps to prevent seizures for as long as you continue to take it. Leviram 500 suppresses the abnormal electrical activity in the brain. You can take it with or without food but try to take it at the same time each day to get the most benefit. The dose will depend on your condition and how you respond to the medicine. Your doctor will advise the right dose for you. It is generally advised as a...
... Show moreUses of Leviram 500
- Epilepsy/Seizures
Side effects of Leviram 500
Common
- Sleepiness
- Dizziness
- Fatigue
- Headache
- Decreased appetite
- Behavioural changes
- Aggressive behavior
- Irritation
- Agitation
- Nasal congestion (stuffy nose)
- Infection
How to use Leviram 500
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Leviram 500 may be taken with or without food, but it is better to take it at a fixed time.
How Leviram 500 works
Leviram 500 is an antiepileptic medication. It works by attaching to specific sites (SV2A) on the surfaces of nerve cells. This suppresses the abnormal activity of the nerve cells in the brain and prevents the spread of electrical signals that cause seizures.
Quick Tips
- Leviram 500 should be taken regularly as directed by your doctor as missing doses can trigger seizures.
- Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
- Some healthy tips to prevent seizures:
- It may cause sleepiness or drowsiness. If this happens to you, do not drive or use machinery.
- Do not stop using Leviram 500 without talking to your doctor, even if you feel better.
Brief Description
Indication
Partial seizures
Administration
May be taken with or without food. Oral soln may be taken directly or diluted in a glass of water.
Adult Dose
Oral Adjunct in seizures Adult: For partial seizures w/ or w/o secondary generalisation; myoclonic seizures (w/ juvenile myoclonic epilepsy); primary generalised tonic-clonic seizures (w/ idiopathic generalised epilepsy): Initially, 500 mg bid on the 1st day. Adjust dose in increments or decrements of 500 mg bid at 2-4 wk intervals. Max: 1,500 mg bid. Monotherapy for partial seizures with or without secondary generalisation Adult: Recommended starting dose is 250 mg bid, increased to an initial therapeutic dose of 500 mg bid after 2 wk. May further increase by 250 mg bid every 2 wk depending upon response. Max: 1,500 mg bid....
... Show moreChild Dose
Oral
Adjunct in seizures
Child: 1 to 6 mth 6 mth <50 kg: Initially, 20 mg/kg daily, may adjust in increments of 20 mg/kg at 2-wk intervals.
Max: 60 mg/kg daily. To be given via infusion over 15 min.
Renal Dose
Renal impairment: ESRD patients undergoing dialysis: Loading dose of 750 mg, followed by 500-1,000 mg once daily; supplemental dose of 250-500 mg after dialysis.
CrCl (ml/min) Dosage Recommendation
<30 250-500 mg bid.
30-49 250-750 mg bid.
50-79 500-1,000 mg bid.
Contraindication
Hypersensitivity.
Mode of Action
Anticonvulsant used in the treatment of partial seizures. The precise mechanism of anticonvulsant effect is unknown.
Precaution
Renal and hepatic impairment; pregnancy, lactation; patients undergoing haemodialysis. If psychotic symptoms (eg hallucination) and behavioural symptoms (eg agitation, anxiety) occur, reduce dosage. Abrupt withdrawal may result in increased seizure frequency. May impair ability to drive or operate machinery during initial therapy.
Lactation: Excreted in breast milk; not recommended
Side Effect
>10%
Asthenia (11-15%),Headache (14-19%),Infection (11-15%),Increased blood pressure (17% in children < 4 years),Somnolence (11-15%),Drowsiness (2-23%),Fatigue (10-11%),Anorexia (3-13%),Weakness (9-15%),Nasopharyngitis (7-15%),Cough (2-11%)
1-10%
Viral infection (2%),Asthma (2%),Dizziness (5-9%),Nervousness (2-10%),Amnesia (2%),Anxiety (2-3%),Ataxia (3%),Depression (2-5%),Hostility (10%),Paresthesia (2%),Sinusitis (2%),Diplopia (2%),Amblyopia (2%),Conjunctivitis (2-3%),Albuminuria (4%)
<1%
Abnormal hepatic function tests,Dyskinesia,Eczema,Neutropenia,Decreased hematocrit,Leukopenia,Suicidal tendencies,Hepatitis,Pancreatitis,Bone marrow suppression,Epidermal necrolysis
Interaction
Enzyme-inducing antiepiletic drugs.
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