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Demelon 4.5
Unimed Unihealth Pharmaceuticals Ltd.
Generic: Rivastigmine
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Demelon 4.5. Please consult your doctor.
SAFE IF PRESCRIBED
Demelon 4.5 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
CONSULT YOUR DOCTOR
Demelon 4.5 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Demelon 4.5 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Demelon 4.5 is safe to use in patients with kidney disease. No dose adjustment of Demelon 4.5 is recommended.
However, inform your doctor if you have underlying kidney diseases as close monitoring is advised while you are taking this medicine.
SAFE IF PRESCRIBED
Demelon 4.5 is safe to use in patients with liver disease. No dose adjustment of Demelon 4.5 is recommended.
However, inform your doctor if you have an underlying liver disease as close monitoring is advised while you are taking this medicine.
Medicine Overview of Demelon 4.5 4.5mg capsule
Introduction
Demelon 4.5 is used to treat mild to moderate dementia in Alzheimer’s disease, a progressive illness which gradually affects memory and thinking. It is also used to treat Parkinson’s disease. It does not cure these illnesses but may help improve memory, awareness and other symptoms. Your doctor will explain how to take Demelon 4.5 and give you the one most suitable for you. Follow the instructions carefully to get the most benefit. The dose may change from time to time to suit your individual needs. You may take it with food, preferably at night before going to bed. It can...
... Show moreUses of Demelon 4.5
- Alzheimer's disease
Side effects of Demelon 4.5
Common
- Vomiting
- Nausea
- Indigestion
How to use Demelon 4.5
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Demelon 4.5 is to be taken with food.
How Demelon 4.5 works
Memory loss in Alzheimer’s disease occurs due to disturbances of signal transmission in the brain. Demelon 4.5 is a cholinesterase inhibitor. It works by increasing the levels of a chemical messenger (acetylcholine) involved in transmmission of nerve signals. This improves memory and thinking.
What if you forget to take Demelon 4.5?
If you miss a dose of Demelon 4.5, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- You have been prescribed Demelon 4.5 to slow down the progression of Alzheimer's disease.
- It does not cure Alzheimer's disease but may help improve brain function and ability to do daily activities.
- It may cause diarrhea, nausea, and vomiting. Drink plenty of fluids to keep yourself hydrated while taking Demelon 4.5.
- Do not drive or do anything that requires mental focus until you know how Demelon 4.5 affects you.
- Be cautious while taking this medicine if you suffer from peptic ulcer as it may cause vomiting, stomach bleeding, stomach pain, or discomfort.
- Inform your doctor if you experience seizures or convulsions while taking this medicine.
Brief Description
Indication
Severe dementia in Alzheimer's disease, Parkinson Dementia
Administration
Should be taken with food.
Adult Dose
Alzheimer Dementia Oral Indicated for mild-to-moderate dementia of the Alzheimer's type Initial: 1.5 mg PO q12hr Increase by 1.5 mg/dose q2Weeks; not to exceed 6 mg PO q12hr Maintenance: 3-6 mg PO q12hr (higher end may be more beneficial) Transdermal Indicated for mild, moderate, and severe dementia of the Alzheimer's type Initial: Apply 4.6 mg q24hr Dose titration: May increase dose to 9.5 mg q24hr after a minimum 4 weeks if well tolerated; after an additional 4 weeks, may further increase to 13.3 mg patch if needed Mild-to-moderate Alzheimer disease: Effective dosage range is 9.5-13.3 mg/24 hr Moderate-to-severe Alzheimer disease:...
... Show moreRenal Dose
Transdermal
Renal impairment: No dosage adjustment required
Contraindication
Hypersensitivity to other carbamate derivatives. Severe hepatic impairment.
Mode of Action
Rivastigmine reversibly inhibits hydrolysis of acetylcholine by cholinesterases thus increasing acetylcholine present in the CNS. It is selective for the CNS and is used for the symptomatic treatment of dementia in Alzheimer's disease and idiopathic Parkinson's disease.
Precaution
Patients with sick sinus syndrome or conduction defects, resp diseases. Cholinergic stimulation may increase gastric acid secretion. May exacerbate urinary obstruction and seizures. Pregnancy. Renal impairment, mild to moderate hepatic impairment. Monitor body wt. Asthma or obstructive pulmonary disease. May worsen extrapyramidal symptoms. Lactation.
Lactation: Unknown if excreted in milk; not recommended
Side Effect
>10%
Nausea (PO 47%; patch 21%),Vomiting (PO 31%; patch 6-19%),Dizziness (PO 21%; patch 2-7%),Diarrhea (PO 19%; patch 6-10%),Headache (PO 17%; patch 3-4%),Anorexia (PO 17%; patch 3-9%),Abdominal pain (PO 13%; patch 2-4%)
1-10%
Decreased weight (3-8%),Insomnia (PO 9%; patch 1-4%),Anxiety (PO 5%; patch 3%),Asthenia (PO 6%; patch 2-3%),Vertigo (2%),Fatigue (2%)
Potentially Fatal: Serious GI reactions such as anorexia, vomiting and weight loss.
Interaction
Not to be used with other cholinomimetic drugs that might interfere with the activity of anticholinergic medications. May exaggerate the effects of succinylcholine-type muscle relaxants during anaesthesia. Tobacco smoking may increase its clearance.
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