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Tofe
Sharif Pharmaceuticals Ltd.
Generic: Tolfenamic Acid
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Tofe.
CONSULT YOUR DOCTOR
Tofe may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of Tofe during breastfeeding is not available. Please consult your doctor.
UNSAFE
Tofe may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
http://www.medicines.org.uk/emc/PIL.29405.latest.pdf
CAUTION
Tofe should be used with caution in patients with kidney disease. Dose adjustment of Tofe may be needed. Please consult your doctor.
Regular monitoring of kidney function tests is advised in these patients while taking this medicine. Use of Tofe is not recommended in severe kidney disease patients.
CAUTION
Tofe should be used with caution in patients with liver disease. Dose adjustment of Tofe may be needed. Please consult your doctor.
Medicine Overview of Tofe 200mg tablet
Introduction
Tofe is a pain relieving medicine. It is used for treatment of pain associated with acute attacks of migraine in adults. It may also be used to relief pain associated with joints and muscles. Tofe can be taken with food, preferably with a glass of water. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep taking the medicine even if you feel better until the doctor says it is alright to stop using it. The most common side effects of this medicine include mild indigestion, diarrhea,...
... Show moreUses of Tofe
- Pain relief
Side effects of Tofe
Common
- Vomiting
- Nausea
- Indigestion
- Diarrhea
- Heartburn
- Loss of appetite
How to use Tofe
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Tofe is to be taken with food.
How Tofe works
Tofe is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling).
Quick Tips
- It should be taken with food or milk to avoid getting an upset stomach.
- It can cause serious complications like stomach bleeding and kidney problems if taken for a long time.
- Tofe can raise your risk of blood clots, heart attack, or a stroke.
- Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
- Inform your doctor if you have ever been diagnosed with kidney or liver problems.
Brief Description
Indication
Mild to moderate pain, Acute migraine attacks
Administration
Should be taken with food. Take w/ or immediately after meals.
Adult Dose
Oral
Acute migraine attacks
Adult: 200 mg when 1st symptoms appear, may be repeated after 1-2 hr, if necessary.
Mild to moderate pain
Adult: 100-200 mg tid.
Hepatic impairment: Severe: Avoid.
Renal Dose
Renal impairment: Severe: Avoid.
Contraindication
Hypersensitivity to aspirin or other NSAID. Active or history of GI bleeding or ulceration, severe heart failure, history of GI bleeding or perforation related to previous NSAID therapy. Severe renal and hepatic impairment. Pregnancy (3rd trimester).
Mode of Action
Tolfenamic acid, an anthranilic acid derivative, is an NSAID. It has anti-inflammatory, analgesic and antipyretic effects.
Precaution
Patient w/ or w/ history of bronchial asthma, uncontrolled HTN, CHF, established ischaemic heart disease, peripheral arterial disease, cerebrovascular disease, coagulation defects, SLE, connective tissue disorders, history of GI disease (e.g. Crohn's disease, ulcerative colitis). Hepatic and renal impairment. Pregnancy and lactation. Patient Counselling This drug may cause dizziness, drowsiness, fatigue and visual disturbances, if affected, do not drive or operate machinery. Monitoring Parameters Monitor renal function.
Side Effect
Dysuria esp in males; tremor, euphoria, fatigue, pulmonary infiltration, nausea, vomiting, diarrhoea, flatulence, constipation, dyspepsia, abdominal pain, melaena, haematemesis, ulcerative stomatitis, exacerbation of Crohn's disease and colitis, gastritis, pancreatitis; oedema, HTN, cardiac failure; nephritis, hepatitis, jaundice, abnormal liver function; visual disturbances, optic neuritis, headache, paraesthesia, depression, confusion, hallucinations, tinnitus, vertigo, tremor, dizziness, malaise, drowsiness; thrombocytopenia, neutropenia, agranulocytosis, anaemia.
Potentially Fatal: Exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis; GI bleeding, ulceration or perforation.
Interaction
Increased rate of absorption of tolfenamic acid with metoclopramide and magnesium hydroxide. Decreased rate of absorption of tolfenamic acid with aluminium hydroxide. Increased risk of bleeding with anticoagulants and other NSAIDs. Decreased antihypertensive response to loop diuretics, ?-blockers and ACE inhibitors. Coadmin increased plasma concentrations of lithium, methotrexate and cardiac glycosides. Increased risk of nephrotoxicity with ACE inhibitors, ciclosporin, tacrolimus or diuretics.
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