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G Tamoxifen
Gonoshasthaya Pharmaceuticals Ltd.
Generic: Tamoxifen
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with G Tamoxifen.
UNSAFE
G Tamoxifen is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
CONSULT YOUR DOCTOR
G Tamoxifen is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
G Tamoxifen may cause side effects which could affect your ability to drive.
G Tamoxifen may cause tiredness. This may affect your driving ability.
SAFE IF PRESCRIBED
G Tamoxifen is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of G Tamoxifen may not be needed in these patients. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of G Tamoxifen in patients with liver disease. Please consult your doctor.
Medicine Overview of G Tamoxifen 20mg Tablet
Introduction
G Tamoxifen is an anti-estrogens. It is used in the treatment of breast cancer. It is also used to reduce the risk of breast cancer in women with a high chance of developing it. This medicine helps to slow down the growth and multiplication of cancer cells. G Tamoxifen is also helpful in the treatment of infertility. It can be taken with or without food, but take it at the same time to get the most benefit. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it...
... Show moreUses of G Tamoxifen
- Breast cancer
Side effects of G Tamoxifen
Common
- Nausea
- Skin rash
- Hot flashes
- Thinning of hair
- Vaginal discharge
- Swelling
How to use G Tamoxifen
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. G Tamoxifen may be taken with or without food, but it is better to take it at a fixed time.
How G Tamoxifen works
G Tamoxifen is a hormone-based medication. It works by binding to estrogen receptors and blocking the effects of estrogen (a natural female hormone) in the breast tissue. This slows down the growth and multiplication of breast cancer cells.
Quick Tips
- G Tamoxifen helps treat breast cancer.
- It also reduces the risk of cancer coming back and of getting cancer in the other breast.
- Use a reliable barrier contraceptive method (such as condoms) to prevent pregnancy while you are taking this medicine and for 2 months after you stop taking it.
- Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
- Inform your doctor if your periods become irregular, especially if associated with heavier bleeding.
- Do not stop taking the medicine without talking to your doctor first.
Brief Description
Indication
Breast cancer
Administration
May be taken with or without food.
Adult Dose
Oral Breast Cancer Treatment 20 mg daily as a single or in 2 divided doses. Max: 40 mg daily. Continue with adjuvant therapy for at least 5 years For women with ER-positive disease, continuing tamoxifen to 10 years rather than stopping at 5 years produces a further reduction in recurrence and mortality, particularly after year 10 Breast Cancer Prevention Indicated to reduce the incidence of breast cancer in women at high risk for breast cancer; high risk is defined as women aged >35 years with a 5-year predicted risk of breast cancer >1.67% (calculated by the Gail Model) Adult: 20...
... Show moreContraindication
History of DVT or pulmonary embolism. Pregnancy and lactation. Concomitant coumarin-type anticoagulant therapy.
Mode of Action
Tamoxifen, a triphenylethylene derivative, produces a nuclear complex by competitively binding to oestrogen receptors on tumours and other tissue targets thus, decreasing DNA synthesis and inhibiting oestrogen effect. It is only cytostatic rather than cytotoxic due to accumulation of cell in G0 and G1 phases.
Precaution
Patient w/ leucopenia and thrombocytopenia, hyperlipidaemias. Monitoring Parameters Perform periodic CBC (e.g. platelet counts) and LFTs. Routine gynaecological monitoring and any abnormal symptoms (e.g. abnormal vag bleeding or discharge, pelvic pain, menstrual irregularities).
Lactation: not known if excreted in breast milk, do not nurse
Side Effect
>10%
Hot flashes (64%),Vaginal discharge (30%),Amenorrhea (16%),Menstrual changes (13%)
1-10%
Oligomenorrhea (9%),Cataracts (8%),Bone pain (6%),Nausea (5%),Cough (4%),Edema (4%),Fatigue (4%),Musculoskeletal pain (3%),Ovarian cyst (3%),Depression (2%),Abdominal cramps (1%),Anorexia (1%)
<1%
Angioedema,Corneal changes,Loss of libido,Endometrial cancer,Pancreatitis,Retinal vein thrombosis,Stroke,Uterine fibroids
Potentially Fatal: Blood dyscrasias, cholestasis, hepatitis, hypercalcaemia in patients with bone metastasis, thromboembolic events. Increased risk of endometrial cancer and uterine sarcoma.
Interaction
Increases dopaminergic effect of bromocriptine. Increased risk of thromboembolic events w/ cytotoxic drugs. Increased risk of bleeding w/ platelet aggregation inhibitors. May mutually reduce effects w/ hormone preparations particularly oestrogens (e.g. OCs). Reduced plasma levels w/ CYP3A4 inducers (e.g rifampicin) and CYP2D6 inhibitors. Increased plasma levels w/ CYP3A4 inhibitors.
Potentially Fatal: Significant increase in anticoagulant effect w/ coumarin-type anticoagulants (e.g. warfarin).
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