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G-Lomustin
Gonoshasthaya Pharmaceuticals Ltd.
Generic: Lomustine
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with G-Lomustin.
CONSULT YOUR DOCTOR
G-Lomustin is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of G-Lomustin during breastfeeding is not available. Please consult your doctor.
CONSULT YOUR DOCTOR
It is not known whether G-Lomustin alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
CAUTION
G-Lomustin should be used with caution in patients with kidney disease. Dose adjustment of G-Lomustin may be needed. Please consult your doctor.
Regular monitoring of kidney function tests is advised while you are taking this medicine. Use of G-Lomustin is not recommended in patients with severe kidney disease.
CONSULT YOUR DOCTOR
There is limited information available on the use of G-Lomustin in patients with liver disease. Please consult your doctor.
However, regular monitoring of liver function tests is advised while you are taking this medicine.
Medicine Overview of G-Lomustin 10mg Capsule
Introduction
G-Lomustin is used in the treatment of different kinds of cancers. It may be also used to treat other conditions, as determined by the doctor. G-Lomustin should be taken on an empty stomach, but try to take it at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very...
... Show moreUses of G-Lomustin
- Brain tumor
- Lung cancer
- Hodgkin’s disease
- Malignant melanoma
Side effects of G-Lomustin
Common
- Nausea
- Vomiting
- Stomatitis (Inflammation of the mouth)
- Hair loss
- Decreased white blood cell count
How to use G-Lomustin
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. G-Lomustin is to be taken empty stomach.
How G-Lomustin works
G-Lomustin is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.
What if you forget to take G-Lomustin?
If you miss a dose of G-Lomustin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Take lomustine as recommended by your doctor preferably on empty stomach.
- Take precautions as lomustine is known to lower the white blood cells and platelets in blood that will make you more prone to infections or you may bleed easily/excessively.
- Seek immediate medical attention if you observe signs of infections such as fever, chills, body ache or if you have unusual bruising or bleeding.
- Do not receive any live vaccines [for eg. measles, mumps, MMR (Rubella), rotavirus, typhoid, yellow fever, chickenpox, zoster and influenza vaccine] while on lomustine treatment.
- Use disposable gloves while handling lomustine capsule to avoid direct contact with medicine.
- Use appropriate contraceptive measures while on lomustine treatment.
- Men are advised not to father children during treatment with lomustine and for up to 6 months afterwards, and should seek advice regarding sperm conservation before the start of treatment with lomustine, as there is a chance that lomustine may cause permanent infertility in men.
- You may need to undergo frequent blood tests and kidney/lung/liver function tests to evaluate drugs effect on your body.
- Contact your doctor if you observe severe side effects such as chest discomfort, difficulty breathing, rapid heart rate, dry cough, wheezing, reduced/no urination, yellowing of skin and eyes (jaundice), pale skin, inability to concentrate.
Brief Description
Indication
Brain tumours, Hodgkin's disease, Lung cancer, Malignant melanoma
Administration
Should be taken on an empty stomach. Take on an empty stomach. May be taken at bedtime to reduce occurrence of nausea.
Adult Dose
Oral
Brain tumours; Hodgkin's disease, resistant or relapsed; Malignant melanoma; Lung cancer
Adult: 100-130 mg/m2 as a single dose every 6 wk. Adjust dose according to platelet and leukocyte counts.
Compromised marrow function: 100 mg/m2 as a single dose every 6 wk.
Child Dose
Oral
Brain tumours; Hodgkin's disease, resistant or relapsed; Malignant melanoma; Lung cancer
Child: 75-150 mg/m2 as a single dose every 6 wk. Readjust dose according to platelet and leukocyte counts.
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
10-50 Admin 75% of normal dose.
<10 Admin 25-50% of normal dose.
Contraindication
Pregnancy and lactation.
Mode of Action
Lomustine inhibits the synthesis of DNA and RNA via alkylation although carbamoylation and modification of cellular proteins may also be involved.
Precaution
Monitor CBC with differential platelet count wkly for at least 6 wk after a dose. Periodically perform pulmonary function studies and LFTs.
Lactation: Unknown if metabolites present in breast milk; avoid nursing during treatment and for 2 weeks after final dose
Side Effect
>10%
Nausea (54%),Vomiting (54%)
1-10%
Neurotoxicity,Myelosuppression (delayed 4-5 weeks)
Frequency Not Defined
Ataxia,Lethargy,Disorientation,Stomatitis,Mucositis,Pulmonary fibrosis (rare),Pulmonary toxicity,Elevated LFTs,Leukemia,Renal toxicity,Hepatic toxicity,Infertility,Alopecia,Optic atrophy (rare)
Potentially Fatal: Delayed bone marrow suppression and permanent marrow damage following prolonged use.
Interaction
Increased levels/effects with CYP2D6 inhibitors.
ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
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