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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Giran.
CONSULT YOUR DOCTOR
Giran is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Giran is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Giran may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Giran is safe to use in patients with kidney disease. No dose adjustment of Giran is recommended.
However, talk to your doctor if you have any underlying kidney disease. Regular monitoring of blood pressure, kidney function test, and potassium levels may be advised.
CAUTION
Giran should be used with caution in patients with liver disease. Dose adjustment of Giran may be needed. Please consult your doctor.
Use of Giran is not recommended in patients with severe liver disease.
Medicine Overview of Giran 16mg Tablet
Introduction
Giran is a medicine used to treat high blood pressure and heart disease. Lowering blood pressure helps to prevent future heart attack and stroke. This medicine is also effective in preserving kidney function in patients with diabetes. Giran can be prescribed either alone or in combination with other medicines. It may be taken with or without food during the day or at night. However, try to take it at the same time each day to get the most benefit. It is important to continue taking it regularly even if you feel well or if your blood pressure is controlled. Most...
... Show moreUses of Giran
- Hypertension (high blood pressure)
- Heart failure
- Prevention of heart attack and stroke
Side effects of Giran
Common
- Dizziness
- Back pain
- Upper respiratory tract infection
- Sore throat
- Nasal congestion (stuffy nose)
How to use Giran
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Giran may be taken with or without food, but it is better to take it at a fixed time.
How Giran works
Giran is an angiotensin receptor blocker (ARB). It relaxes the blood vessel by blocking the action of a chemical that usually makes blood vessels tighter. This lowers the blood pressure, allowing the blood to flow more smoothly to different organs and the heart to pump more efficiently.
What if you forget to take Giran?
If you miss a dose of Giran, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- It can make you feel dizzy for the first few days. Rise slowly if you have been sitting or lying down for a long time.
- Your doctor may get regular tests done to monitor the level of urea, creatinine, and potassium in your blood.
- Avoid taking anti-inflammatory medicines such as ibuprofen along with this medicine without consulting your doctor.
- Do not take Giran if you are pregnant or breastfeeding.
- Do not stop taking it suddenly without talking to your doctor.
Brief Description
Indication
Hypertension, Congestive heart failure
Administration
May be taken with or without food.
Adult Dose
Oral
Hypertension
Adult: Initially, 8 mg once daily adjusted according to response. Maintenance: 8 mg once daily. Max: 32 mg/day as single or in 2 divided doses. Patients w/ intravascular volume depletion: Initially, 4 mg once daily.
Heart failure
Adult: Initially, 4 mg once daily, may be doubled at intervals of not <2 wk. Max: 32 mg once daily.
Hepatic impairment: Mild to moderate: Initially, 4 mg once daily. Severe: Contraindicated.
Child Dose
Oral
Hypertension
Child: 1 to 6 yr 50 kg: 8-16 mg/day, adjusted according response to 4-32 mg/day.
All doses may be given as single or in 2 divided doses.
Renal Dose
Renal Impairment
No dose adjustment necessary for patients with mild renal impairment
Initiate thearpy at lower dose if moderate renal impairment
Contraindication
Hypersensitivity. Pregnancy (2nd and 3rd trimester) and lactation.
Mode of Action
Candesartan inhibits the binding of angiotensin II to AT1 receptors in many tissues (e.g. vascular smooth muscles, adrenal gland) which leads to vasoconstriction blockade and aldosterone release.
Precaution
Volume or sodium depletion, preexisting renal insufficiency; aortic or mitral valve stenosis, hypertrophic obstructive cardiomyopathy, renal artery stenosis, primary hyperaldosteronism. Patients with a history of angioedema, urticaria. Monitor serum potassium levels especially in elderly and renally impaired patients. Hypotension may occur during major surgery and anaesthesia due to suppression of the renin-angiotensin system. Discontinue as soon as pregnancy detected; during the second and third trimesters of pregnancy, drugs that act directly on the renin-angiotensin have been associated with fetal injury that includes hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death Lactation: Not known if excreted in...
... Show moreSide Effect
Dizziness, headache, vertigo, back pain, upper resp tract infections, pharyngitis, rhinitis, hypotension, hyperkalaemia, increased serum creatinine.
Pregnancy Category Note
Pregnancy Category: D
Discontinue as soon as pregnancy detected; during the second and third trimesters of pregnancy, drugs that act directly on the renin-angiotensin have been associated with fetal injury that includes hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death
Lactation: Not known if excreted in breast milk; not recommended
Interaction
NSAIDs may reduce antihypertensive effect and result in deterioration of renal function including possible acute renal failure. May increase serum lithium concentration. K-sparing diuretics, K supplements or salt substitutes containing K may increase risk of hyperkalaemia.
Potentially Fatal: Coadministration w/ aliskiren in diabetic patients may increase risk of renal impairment, hypotension and hyperkalaemia.
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