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Giran H
Aristopharma Limited
Generic: Candesartan Cilexetil + Hydrochlorothiazide
Safety Advices
বাংলা
English
UNSAFE
Giran H may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Giran H is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Giran H is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Giran H may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Giran H should be used with caution in patients with severe kidney disease. Dose adjustment of Giran H may be needed. Please consult your doctor.
Use of Giran H is not recommended in patients with severe kidney disease.
CAUTION
Giran H should be used with caution in patients with liver disease. Dose adjustment of Giran H may be needed. Please consult your doctor.
Medicine Overview of Giran H 8mg+12.5mg Tablet
Introduction
Giran H is a combination of two medicines. It helps to control high blood pressure in different ways. If high blood pressure is not treated it can lead to heart attacks, strokes and kidney failure. You can take Giran H with or without food. The dose will depend on your condition and how your respond to the medicine. Try to take it at the same time each day. It is important to keep taking this medicine until your doctor tells you not to. It contains a diuretic (water pill) and will make you urinate more so, it is best to...
... Show moreUses of Giran H
- Hypertension (high blood pressure)
Side effects of Giran H
Common
- Nausea
- Taste change
- Stomach pain
- Diarrhea
- Weakness
- Dizziness
- Headache
- Decreased blood pressure
- Increased blood uric acid
- Electrolyte imbalance
- Glucose intolerance
- Increased blood lipid level
How to use Giran H
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Giran H may be taken with or without food, but it is better to take it at a fixed time.
How Giran H works
Giran H is a combination of two medicines: Candesartan and hydrochlorothiazide which lower blood pressure effectively. Candesartan is an angiotensin receptor blocker (ARB). It works by blocking the hormone angiotensin thereby relaxing blood vessels.This allows the blood to flow more smoothly and the heart to pump more efficiently. Hydrochlorothiazide is a diuretic that removes extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow.
Quick Tips
- You have been prescribed Candelong H 8mg/12.5mg Tablet for the treatment of high blood pressure.
- It can be taken with or without food.
- Candelong H 8mg/12.5mg Tablet may cause dehydration. Drink plenty of fluids and inform your doctor if you develop extreme thirst, very dry mouth or muscle weakness.
- It may cause dizziness. Get up slowly when rising from a sitting or lying position.
- Use of Candelong H 8mg/12.5mg Tablet during pregnancy or breastfeeding is unsafe.
- It may also decrease the risk of stroke and heart attacks.
Brief Description
Indication
Hypertension, Congestive heart failure
Administration
May be taken with or without food.
Adult Dose
Hypertension
16-32 mg candesartan/12.5-25 mg HCTZ PO: 1 tablet once daily.
Elderly: No dosage adjustment is necessary in elderly patients.
Impaired Hepatic Function: Patients with Hepatic Impairment: Dose titration is recommended in patients with mild to moderate chronic liver disease.
This should not be used in patients with severe hepatic impairment and/or cholestasis.
Child Dose
The safety and efficacy have not been established in children.
Renal Dose
Impaired Renal Function:
In patients with mild to moderate renal impairment (ie, creatinine clearance between 30-80 mL/min/1.73m2 BSA), a dose titration is recommended.
This should not be used in patients with severe renal impairment (creatinine clearance <30 mL/min/1.73 m2 BSA).
Contraindication
Hypersensitivity.
Mode of Action
Candesartan inhibits the binding of angiotensin II to AT1 receptors in many tissues (e.g. vascular smooth muscles, adrenal gland) which leads to vasoconstriction blockade and aldosterone release.
Hydrochlorothiazide inhibits the reabsorption of Na and chloride in the distal tubules causing increased excretion of Na and water K and hydrogen ions.
Precaution
Volume or sodium depletion, preexisting renal insufficiency; aortic or mitral valve stenosis, hypertrophic obstructive cardiomyopathy, renal artery stenosis, primary hyperaldosteronism. Patients with a history of angioedema, urticaria. Monitor serum potassium levels especially in elderly and renally impaired patients. Hypotension may occur during major surgery and anaesthesia due to suppression of the renin-angiotensin system.
Lactation: enters breast milk/contraindicated
Side Effect
1-10%
Headache (3%),Dizziness (3%),Upper respiratory tract infection (4%),Back pain (3%),Flu-like syndrome (2%)
Frequency Not Defined
Candesartan
Dizziness, headache, vertigo, back pain, upper resp tract infections, pharyngitis, rhinitis, hypotension, hyperkalaemia, increased serum creatinine.
Hydrochlorothiazide
Anorexia,Epigastric distress,Hypotension,Orthostatic hypotension,Photosensitivity,Anaphylaxis,Anemia,Confusion,Erythema multiforme,Stevens-Johnson syndrome,Exfoliative dermatitis including toxic epidermal necrolysis,Dizziness,Headache,Hyperuricemia,Hypokalemia and/or hypomagnesemia
Pregnancy Category Note
Pregnancy Category: C (1st trimester); D (2nd and 3rd trimesters)
Lactation: enters breast milk/contraindicated
Interaction
NSAIDs may reduce antihypertensive effect and result in deterioration of renal function including possible acute renal failure. May increase serum lithium concentration. K-sparing diuretics, K supplements or salt substitutes containing K may increase risk of hyperkalaemia.
Potentially Fatal: Coadministration w/ aliskiren in diabetic patients may increase risk of renal impairment, hypotension and hyperkalaemia.
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