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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Gle 80.
CONSULT YOUR DOCTOR
Gle 80 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Gle 80 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Gle 80 does not usually affect your ability to drive.
CAUTION
Gle 80 should be used with caution in patients with severe kidney disease. Dose adjustment of Gle 80 may be needed. Please consult your doctor.
These patients can experience very low blood sugar levels with this medicine, which may take a long time to come back to normal
CAUTION
Gle 80 should be used with caution in patients with severe liver disease. Dose adjustment of Gle 80 may be needed. Please consult your doctor.
Medicine Overview of Gle 80mg Tablet
Introduction
Gle 80 is a medicine used to treat type 2 diabetes mellitus in adults. It belongs to a group of medicines called sulfonylureas and helps control blood sugar levels in people with diabetes. This helps to prevent serious complications of diabetes like kidney damage and blindness. Gle 80 may be used by itself or along with other medicines. It should be taken with food. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you and this may change from time to time according to how it...
... Show moreUses of Gle 80
- Type 2 diabetes mellitus
Side effects of Gle 80
Common
- Upset stomach
- Indigestion
How to use Gle 80
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Gle 80 is to be taken with food.
How Gle 80 works
is an antidiabetic medication. It works by increasing the amount of insulin released by the pancreas in order to lower the blood sugar levels.
What if you forget to take Gle 80?
You should skip a dose of Gle 80 if a meal is skipped, and add a dose of medicine if you eat an extra meal.
Quick Tips
- Take it shortly before or with the first main meal of the day (usually breakfast). Avoid skipping meals.
- Be careful while driving or operating machinery until you know how Diamicron XR 60 Tablet affects you.
- It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
- Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor and anxiety.
- Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms, such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
Brief Description
Indication
Type 2 DM
Administration
Should be taken 30 mintues before meal or with meal.
Adult Dose
Oral
Type 2 diabetes mellitus
Adult: Initially, 40-80 mg daily gradually increased to 320 mg daily if necessary. Doses >160 mg daily are given in 2 divided doses.
Modified-release tab: Initially, 30 mg once daily, may increase in increments of 30 mg up to max 120 mg daily. Interval between doses should be at least 1 mth.
For non-respondent patients, dose may be increased after 2 wk.
Contraindication
Type 1 DM, diabetes complicated with ketoacidosis; hypersensitivity; severe renal and hepatic impairment. Pregnancy and lactation.
Mode of Action
Gliclazide stimulates insulin secretion from pancreatic beta-cells, reduces insulin uptake and glucose output by the liver, and increases insulin sensitivity at peripheral target sites. It decreases microthrombosis by partial inhibition of platelet aggregation and adhesion, and by restoring fibrinolysis w/ an increase in tissue plasminogen activator (t-PA) activity.
Precaution
Monitor blood glucose concentration. May require insulin during metabolic stress. Care when transferring from combination therapy. Increased risk of severe hypoglycaemia in elderly, debilitated patients, patients with hepatic or renal impairment. Risk of hypogylcaemia when caloric intake is deficient, after strenuous exercise, when taken with ethanol or when >1 antidiabetic drug is used.
Side Effect
GI disturbances, skin reaction, leucopenia, thrombocytopenia, agranulocytosis, haemolytic anaemia, cholestatic jaundice, vomiting, diarrhoea, gastritis, increased transaminases.
Interaction
May increase hypoglycaemic effect w/ phenylbutazone. Potentiation of blood glucose lowering effect w/ other antidiabetics (e.g. acarbose, insulins, metformin), beta-blockers, ACE inhibitors, H2-receptor antagonists, MAOIs, sulfonamides, clarithromycin and NSAIDs. Chlorpromazine, glucocorticoids, ritodrine, salbutamol and terbutaline may cause increases in blood glucose levels. May diminish hypoglycaemic effect w/ danazol. May increase anticoagulant effect of warfarin.
Potentially Fatal: Increased hypoglycaemic effect w/ miconazole
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