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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Glibenol.
SAFE IF PRESCRIBED
Glibenol is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Glibenol is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Monitor the breastfed baby’s blood sugar during treatment with Glibenol
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
UNSAFE
Glibenol is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.
CAUTION
Glibenol should be used with caution in patients with liver disease. Dose adjustment of Glibenol may be needed. Please consult your doctor.
Use of Glibenol is not recommended in patients with severe liver disease. They can experience very low blood sugar levels while taking this medicine.
Medicine Overview of Glibenol 5mg Tablet
Introduction
Glibenol is a medicine used to treat type 2 diabetes mellitus in adults. It belongs to a group of medicines called sulfonylureas and helps control blood sugar levels in people with diabetes. This helps to prevent serious complications of diabetes like kidney damage and blindness. Glibenol may be used by itself or along with other medicines. It should be taken with food. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you and this may change from time to time according to how it is working....
... Show moreUses of Glibenol
- Type 2 diabetes mellitus
Side effects of Glibenol
Common
- Hypoglycemia (low blood glucose level)
- Nausea
- Headache
- Dizziness
How to use Glibenol
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Glibenol is to be taken with food.
How Glibenol works
Glibenol is an antidiabetic medication. It works by increasing the amount of insulin released by the pancreas in order to lower blood glucose.
What if you forget to take Glibenol?
You should skip a dose of Glibenol if a meal is skipped, and add a dose of medicine if you eat an extra meal.
Quick Tips
- Take it shortly before or with the first main meal of the day (usually breakfast). Avoid skipping meals.
- Be careful while driving or operating machinery until you know how Glibenol affects you.
- It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
- Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor and anxiety.
- Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms, such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
Brief Description
Indication
Type 2 DM
Administration
Should be taken with food. Take w/ breakfast or the 1st main meal of the day.
Adult Dose
Oral
Type 2 diabetes mellitus
Adult: Initially, 2.5-5 mg daily, may increase wkly by increments of 2.5-15 mg daily. Doses >10 mg daily should be given in 2 divided doses. Max: 20 mg daily.
Elderly: Initially, 1.25 mg daily.
Hepatic impairment: Severe: Contraindicated.
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment: Severe: Contraindicated.
Contraindication
Severe or life-threatening hyperglycaemia, severe liver or renal failure, type 1 diabetes, diabetic ketoacidosis with or without coma, patients with severe infection or trauma.
Mode of Action
Glibenclamide lowers blood glucose concentration principally by stimulating secretion of endogenous insulin from the pancreatic beta-cells. Hypoglycaemic action associated w/ short-term therapy appears to include reduction of basal hepatic glucose production and enhancement of peripheral insulin action at target sites.
Precaution
Elderly; malnourished; mild to moderate renal and hepatic disorders. Impaired alertness. Avoid alcohol. Careful monitoring of blood-glucose concentration. Adrenocortical insufficiency. Changes in diet or prolonged exercise may also provoke hypoglycaemia. Increased risk of hypoglcaemia due to its long half-life. Avoid in severe hepatic impairment. Pregnancy, lactation.
Lactation: Not known if crosses into breast milk; avoid use in nursing women
Side Effect
Hypoglycaemia; cholestatic jaundice; agranulocytosis; aplastic anaemia; haemolytic anaemia. Blood dyscrasias (reversible), liver dysfunction, GI symptoms, allergic skin reactions.
Potentially Fatal: Prolonged hypoglycaemia seen in elderly or debilitated patients with hepatic or renal diseases.
Interaction
Serum levels may be reduced by colesevelam. May increase hypoglycaemic effect w/ MAOIs, chloramphenicol, fluoroquinolones (e.g. ciprofloxacin), probenecid, NSAIDs, ACE inhibitors, fluoxetine, disopyramide, clarithromycin, salicylates, sulfonamides, beta-blockers. Increased serum levels w/ antifungal antibiotics (e.g. miconazole, fluconazole). May decrease hypoglycaemic effect w/ nonthiazide (e.g. furosemide) and thiazide diuretics, corticosteroids, phenothiazines, thyroid agents, oestrogens, OC, phenytoin, nicotinic acid, sympathomimetic agents, rifampicin, Ca channel blockers, isoniazid.
Potentially Fatal: May increase hepatotoxic effect of bosentan.
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