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Gludex
Kemiko Pharmaceuticals Ltd.
Generic: Dexamethasone
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Gludex.
CONSULT YOUR DOCTOR
Gludex may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Gludex is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Gludex may cause side effects which could affect your ability to drive.
Gludex may cause dizziness (vertigo). Changes in your eyesight or muscle weakness may also happen. This may affect your driving ability.
SAFE IF PRESCRIBED
Gludex is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Gludex may not be needed in these patients. Please consult your doctor.
Regular monitoring of kidney function tests and other blood tests is advisable while you are taking Gludex.
CAUTION
Gludex should be used with caution in patients with liver disease. Dose adjustment of Gludex may be needed. Please consult your doctor.
Medicine Overview of Gludex 0.5mg Tablet
Introduction
Gludex belongs to a group of medicines called steroids. It is used in the treatment of various diseases and conditions (such as severe allergic reactions, asthma, rheumatic disorder, skin disorders, and eye disorders). Gludex provides relief from swelling, redness, pain, and itching in the affected area by preventing the release of substances that cause inflammation. It should be taken with food to avoid stomach upset. Taking the medicine regularly at the right times increases its effectiveness. It is important to keep taking the medicine regularly until your doctor tells you it is safe to stop. The most common side effects...
... Show moreUses of DEXAMETHASONE(IPC) Tablet
- Allergic conditions
- Severe allergic reactions
- Asthma
- Cancer
- Rheumatic disorder
- Skin disorders
- Eye disorders
- Nephrotic syndrome
Side effects of DEXAMETHASONE(IPC) Tablet
Common
- Mood changes
- Reduction in bone density
- Upset stomach
How to use DEXAMETHASONE(IPC) Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Gludex is to be taken with food.
How DEXAMETHASONE(IPC) Tablet works
Gludex is a steroid which works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies.
Quick Tips
- DEXAMETHASONE Tablet helps treat inflammation, severe allergies, flare-ups of ongoing illnesses, and many other medical problems that require either reduction of inflammation or suppression of the immune system.
- Do not use it more often or for longer than advised by your doctor.
- Take it with food to avoid an upset stomach.
- DEXAMETHASONE Tablet can make it harder for you to fight off infections. Notify your doctor if you have any signs of infection such as a fever or sore throat.
- Side effects such as mood changes or stomach problems can happen when you start taking DEXAMETHASONE Tablet. Inform your doctor if this bothers you.
- Do not stop taking DEXAMETHASONE Tablet suddenly without talking to your doctor first as it may worsen your symptoms.
Brief Description
Indication
Shock, Bronchial asthma, Status asthmaticus, Rheumatoid arthritis, Gout, Severe allergies, Skin diseases, Hyperpyrexia, Bacteraemia, Toxaemia, Acute adrenocortical insufficiency, Cortisosteroid-responsive dermatoses, Eczema, Urticaria, Cerebral oedema, other indications where glucocorticoid therapy is required.,
Administration
Should be taken with food.
Adult Dose
Oral Anti-inflammatory Adult: 0.75-9 mg daily in 2-4 divided doses; Screening test for Cushing's syndrome Adult: 0.5 mg every 6 hr for 48 hr after determining baseline 24-hr urinary 17-hydroxycorticosteroid (17-OHCS) concentrations. During the second 24 hr of dexamethasone admin, urine is collected and analysed for 17-OHCS. Alternatively, after a baseline plasma cortisol determination, 1 mg may be given at 11 pm and plasma cortisol determined at 8 am the next morning. Plasma cortisol and urinary output of 17-OHCS are depressed after dexamethasone admin in normal individuals but remain at basal levels in patients with Cushing's syndrome. Acute exacerbations in...
... Show moreChild Dose
Oral
Anti-inflammatory
Child: 1 mth-18 yr: 10-100 mcg/kg daily in 1-2 divided doses via oral admin, adjusted according to response; up to 300 micrograms/kg daily may be used in emergency situations.
Acute exacerbations in multiple sclerosis
Child: 1 mth-12 yr: 100-400 mcg/kg daily in 1-2 divided doses; 12-18 yr: Initially 0.5-24 mg daily. Max. 24 mg daily.
Contraindication
Ocular herpes simplex is an example of absolute contraindication to corticosteroid therapy. Relative contraindications are:
Gastrointestinal ulcer, acute or chronic infections, osteoporosis, pregnancy, diabetes mellitus, renal insufficiency, hypertension, history of psychotic illness, immediate before prophylactic immunization and finally hypersensitivity to Dexamethasone.
Mode of Action
Dexamethasone is a synthetic glucocorticoid which decreases inflammation by inhibiting the migration of leukocytes and reversal of increased capillary permeability. It suppresses normal immune response.
Precaution
Dexamethasone should be used with caution in the presence of congestive heart failure or hypertension, in patients with diabetes mellitus, epilepsy, glaucoma, infectious disease, chronic renal failure and uraemia and in elderly persons.
Lactation: Drug excreted in breast milk; not recommended
Side Effect
Acne,Adrenal suppression,Arrhythmia,Bradycardia,Cardiac arrest,Cataracts,Change in spermatogenesis,Delayed wound healing,Depression,Diabetes mellitus,Diaphoresis,Emotional instability,Erythema,Euphoria,Exophthalmos,GI perforation,Glaucoma,Glucose intolerance,Glucosuria,Hepatomegaly,Hypokalemic alkalosis,Increased intracranial pressure,Increased transaminases,Insomnia,Kaposi's sarcoma,Menstrual irregularity,Moon face,Myopathy,Neuritis,Osteoporosis,Peptic ulcer,Perianal pruritus,Petechia,Perianal pruritus,Pituitary adrenal axis suppression,Pseudotumor cerebri (on withdrawal),Psychosis,Pulmonary edema,Rash,Seizure,Spermatogenesis altered (increased or decreased),Ulcerative esophagitis,Urticaria,Vertigo,Weight gain
Pregnancy Category Note
Pregnancy Corticosteroids readily cross the placenta Adverse developmental outcomes including orofacial clefts (cleft lip with or without cleft palate), intrauterine growth restriction, and decreased birth weight have been reported with maternal use of corticosteroids during pregnancy Pregnancy testing is recommended for females of reproductive potential before initiating treatment Contraception Use effective contraception during treatment and for at least 1 month following final dose Infertility in males Steroids may increase or decrease motility and number of spermatozoa in some patients In animals, dexamethasone affects male spermatogenesis Lactation Systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous...
... Show moreInteraction
Increased risk of hypokalaemia when used concurrently with potassium-depleting drugs such as amphotericin B and loop diuretics. Reduces efficacy of isoniazid, salicylates, vaccines and toxoids. Increased activity of dexamethasone and cyclosporin when used together. Concurrent use with aspirin or ethanol may lead to increased GI side effects.
Potentially Fatal: Reduced efficacy in combination with ephedrine, cholestyramine, phenytoin, phenobarbital and rifampicin.
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