12-24 Hours
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Mycept-S 360
Healthcare Pharmaceuticals Ltd.
Generic: Mycophenolic Acid (Mycophenolate sodium)
Medicine Overview of Mycept-S 360mg tablet
বাংলা
English
Indication
Kindey transplant rejection
Administration
Drug is taken on empty stomach 1 hour before or 2 hours after meals
Adult Dose
Oral
Adult
Kidney transplant patients
As Mycophenolic Acid (MPA) (As Mycophenolate sodium): 720 mg twice daily.
Child Dose
Oral
Child
Kidney transplant patients
As Mycophenolic Acid (MPA) (As Mycophenolate sodium):
5 years or above: 400 mg/m2 twice daily.
Renal Dose
Renal impairment
No dosage adjustment needed in renal transplant patients experiencing delayed graft function post-operatively.
Contraindication
Contraindicated to patients with hypersensitivity to mycophenolic acid or any of its excipients.
Mode of Action
Mycophenolic acid acts by blocking purine synthesis of human lymphocytes through reversible inhibition of inosine monophosphate dehydrogenase. It also inhibits proliferation of both T- and B- lymphocytes.
Precaution
Can cause embryofetal toxicity
Increases new or reactive viral infection
Cause blood dyscrasias
Can cause serious GI tract complication
Use of live vaccine should be avoided
Active peptic ulcer disease.
Severe renal impairment.
Lactation: Unknown whether drug is excreted in breast milk; avoid using, or do not nurse
Side Effect
>10%
Hyperglycemia (44%),Hypercholesterolemia (41%),Hypomagnesemia (39%),Dyspnea (37%),Back pain (35%),Increased blood urea nitrogen (BUN) (35%),Leukopenia (34%),Pleural effusion (34%),Urinary tract infection (34%),Increasing frequency of cough (31%),Hypocalcemia (30%),Hypertension (28%),Abdominal pain (27%),Peripheral edema (27%),Anemia (26%),Fever (23%),Nausea (23%),Hyperkalemia (22%),Diarrhea (21%),Infection (21%),Headache (16%)
1-10%
Melanoma (1.6-4.2%),Other malignancies (0.7-2.1%),Lymphoma (0.4-1%),Opportunistic infection (including herpes),Neutropenia,GI bleeding,Pulmonary fibrosis,Progressive multifocal leukoencephalopathy
Potentially Fatal: Angioedema, anaphylaxis, fatal pulmonary fibrosis.
Interaction
Increased plasma levels of both drugs when combined with aciclovir, valaciclovir, ganciclovir and valganciclovir. Reduced absorption with colestyramine, magnesium- and aluminium hydroxide-containing products, sevelamer and other calcium-free phosphate binders. Reduced plasma levels with ciclosporin, metronidazole, quinolones, rifamycins. May reduce plasma levels of progestins; may reduce efficacy of oral contraceptives. Increased plasma levels with probenecid. May reduce efficacy of live vaccines.
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