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Hipre PLUS
Pacific Pharmaceuticals Ltd.
Generic: Amlodipine + Atenolol
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Hipre PLUS.
CONSULT YOUR DOCTOR
Hipre PLUS is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
Hipre PLUS is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Hipre PLUS may cause side effects which could affect your ability to drive.
Hipre PLUS may cause side effects such as dizziness, headaches, nausea or tiredness, all of which could affect your ability to concentrate and drive.
CAUTION
Hipre PLUS should be used with caution in patients with kidney disease. Dose adjustment of Hipre PLUS may be needed. Please consult your doctor.
Regular monitoring of blood pressure is recommended and can help in better dose adjustment.
CAUTION
Hipre PLUS should be used with caution in patients with liver disease. Dose adjustment of Hipre PLUS may be needed. Please consult your doctor.
Hipre PLUS is started at a lower dose in patients with liver disease and further increased slowly with careful monitoring.
Medicine Overview of Hipre PLUS 5mg+50mg Tablet
Introduction
Hipre PLUS is used to treat hypertension (high blood pressure). This is a combination of two medicines that controls blood pressure when a single medication is not effective. It helps to lower high blood pressure and thus reduces the chances of future heart attack and stroke. You can take Hipre PLUS at any time of day, on empty stomach, but it is best to take it at the same time each day. Keep taking it for as long as advised by your doctor. Even if you feel well, do not stop this medicine on your own because high blood pressure...
... Show moreUses of Hipre PLUS
- Hypertension (high blood pressure)
Side effects of Hipre PLUS
Common
- Sleepiness
- Headache
- Ankle swelling
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Slow heart rate
- Palpitations
- Nausea
- Edema (swelling)
- Constipation
- Tiredness
- Cold extremities
How to use Hipre PLUS
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Hipre PLUS is to be taken empty stomach.
How Hipre PLUS works
Hipre PLUS is a combination of two medicines: Amlodipine and Atenolol, which lowers blood pressure effectively. Amlodipine is a calcium channel blocker which works by relaxing blood vessels while atenolol is a beta blocker which works specifically on the heart to slow down the heart rate. Together, they make the heart more efficient at pumping blood throughout the body.
Quick Tips
- You have been prescribed Hipre PLUS for the treatment of high blood pressure.
- Lowering blood pressure reduces chance of future heart attack & strokes.
- It may cause dizziness. Get up slowly when rising from a sitting or lying position.
- Do not stop taking the medication suddenly without talking to your doctor as it can cause sudden increase in your blood pressure.
- Let your doctor know if you are pregnant or planning for pregnancy.
Brief Description
Indication
Oral
Chronic stable angina; Hypertension
Adult: Per tablet contains atenolol 25 or 50 mg and amlodipine 5 mg: 1 tab once daily, may increase to 2 tablets daily if needed.
Elderly: Per tablet contains atenolol 25 mg and amlodipine 5 mg: Initiate with 1 tablet daily.
Administration
Additive effect when used with catecholamine depleting drugs; monitor for hypotension and/or marked bradycardia. If used with clonidine, clonidine withdrawal should occur a few days after withdrawal of the beta-blocker to prevent rebound hypertension; if replacing clonidine by beta-blocker, beta-blocker should be introduced only after clonidine administration has stopped for several days. Concurrent use with prostaglandin synthase inhibiting drugs (e.g. indomethacin) may reduce the hypotensive effects of beta-blockers.
Adult Dose
Excessive fall of BP may occur in elderly patients. Caution in patients with COPD, thyrotoxicosis, congestive failure, vasospastic angina, hepatic & renal impairment. Caution in diabetic patients as beta-blockers may mask tachycardia occurring with hypoglycaemia. Withdrawal should be gradual. Lactation. Safety and efficacy have not been established in children. Not to be used in untreated phaeochromocytoma.
Renal Dose
Atenolol is a cardioselective beta blocker. Amlodipine is a dihydropyridine calcium-channel blocker that blocks the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Combination of the two drugs results in additive antihypertensive action.
Contraindication
Safety and efficacy have not been established in children.
Precaution
Essential hypertension, Patients with angina pectoris & hypertension as co-existing diseases, Post MI patients; In patients with refractory angina pectoris where nitrate therapy has failed.
Side Effect
Renal impairment: Per tablet contains atenolol 25 mg and amlodipine (besylate) 5 mg: Initiate with 1 tablet daily.
Pregnancy Category Note
Headache, hypotension, dizziness, breathlessness, fatigue, muscle cramps, bradycardia, palpitations, flushing, oedema, dyspnoea, dyspepsia, cold extremities. Drowsiness, chestpain & impotence rarely. Hypersensitivity reactions.
Interaction
Hypotension, sinus bradycardia, 2nd & 3rd degrees of heart block, cardiogenic shock, overt congestive failure, poor LV function, hypersensitivity to either component, pregnancy.
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