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Holicef IM
Concord Pharmaceuticals Ltd.
Generic: Ceftriaxone
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Holicef IM does not cause any harmful side effects.
SAFE IF PRESCRIBED
Holicef IM is safe to use during pregnancy. Most studies have shown low or no risk to the developing baby.
CAUTION
Holicef IM should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
UNSAFE
Holicef IM may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Holicef IM is safe to use in patients with kidney disease. No dose adjustment of Holicef IM is recommended.
However, inform your doctor if you have any underlying kidney disease.
CAUTION
Holicef IM should be used with caution in patients with severe liver disease. Dose adjustment of Holicef IM may be needed. Please consult your doctor.
Dose adjustment of Holicef IM is not recommended in patients with mild to moderate liver disease.
Medicine Overview of Holicef IM 250mg/vial Injection
Introduction
Holicef IM is an antibiotic belonging to the cephalosporin group, which is used to treat bacterial infections in your body. It is effective in infections of the brain (e.g., meningitis), lungs (e.g., pneumonia), ear, urinary tract, skin & soft tissues, bones & joints, blood and heart. Holicef IM is also used to prevent infections during surgery. It fights the infection by killing the bacteria. This helps to improve your symptoms and cure the underlying infection. It is given as a drip (intravenous infusion) or as an injection directly into a vein or a muscle under the supervision of a healthcare...
... Show moreUses of Holicef IM
- Bacterial infections
Side effects of Holicef IM
Common
- Abnormal liver function tests
- Diarrhea
- Rash
How to use Holicef IM
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Holicef IM works
Holicef IM is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
What if you forget to take Holicef IM?
If you miss a dose of Holicef IM, please consult your doctor.
Quick Tips
- Your doctor has prescribed Holicef IM to cure your infection and improve your symptoms.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
- Discontinue Holicef IM and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
Brief Description
Indication
Pneumonia, Meningitis, Acute otitis media, Lyme disease, Typhoid fever, Otitis media, Pelvic inflammatory disease, Septicemia, Skin and Skin-Structure Infections, Gonorrhea, Respiratory tract infections, Urinary tract infections, Bone and Joint Infections, Chlamydia infection, Surgical Prophylaxis
Administration
IV/IM Administration
IV: Infuse intermittently over 30 minutes
IM: Inject deep into large muscle mass
Adult Dose
Susceptible infections IV/IM 1-2 g/day, up to 4 g/day for severe infections. Intra-abdominal Infections Complicated, mild-to-moderate, community acquired: 1-2 g/day IV in single daily dose or divided q12hr for 4-7 days, in combination with metronidazole Meningitis 2 g IV q12hr for 7-14 days Acute Uncomplicated Pyelonephritis 1-2 g IV qDay Typhoid fever 2 g IV once daily for 14 days. Surgical Prophylaxis Prophylaxis of surgical infection 1 g IV 0.5-2 hours before procedure Uncomplicated Gonococcal Infections Uncomplicated gonococcal infection of pharynx, cervix, urethra, or rectum: ceftriaxone 250 mg IM once plus azithromycin 1 g PO once (preferred) or alternatively, doxycycline...
... Show moreChild Dose
Children: IV, IM: 50–75 mg/kg/day, max 2 g/day q24h
50 mg/kg, max 1 g, 1–3 doses IM for AOM q24h
100 mg/kg/day for meningitis, max 4 g/day q12h
Renal Dose
Renal impairment:
CrCl (ml/min)
<10 Max: 2 g daily.
Contraindication
Hypersensitivity to cephalosporins; hyperbilirubinaemic neonates. Do not use calcium or calcium-containing solutions or products with or within 48 hr of ceftriaxone administration due to risk of calcium-ceftriaxone precipitate formation.
Mode of Action
Ceftriaxone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Precaution
History of penicillin allergy; severe renal impairment; pregnancy and lactation; superinfection.
Lactation: Drug enters breast milk in low concentrations; use with caution
Side Effect
>10%
Induration after IM injection (5-17%)
1-10%
Eosinophilia (6%),Thrombocytosis (5%),Diarrhea (3%),Elevated hepatic transaminases (3%),Leukopenia (2%),Rash (2%),Increased blood urea nitrogen (BUN) (1%),Induration at IV site (1%),Pain (1%)
<1%
Agranulocytosis,Anaphylaxis,Anemia,Basophilia,Bronchospasm,Candidiasis,Chills,Diaphoresis,Dizziness,Dysgeusia,Flushing,Gallstones,Glycosuria,Headache,Hematuria,Hemolytic anemia,Increased alkaline phosphatase or bilirubin,Increased creatinine,Jaundice,Leukocytosis,Lymphocytosis,Lymphopenia,Monocytosis,Nausea,Neutropenia,Phlebitis,Prolonged or decreased prothrombin time (PT),Pruritus,Renal stones,Serum sickness,Thrombocytopenia,Urinary casts,Vaginitis,Vomiting
Pregnancy Category Note
Pregnancy category: B
Lactation: Drug enters breast milk in low concentrations; use with caution
Interaction
May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate. May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase serum level w/ probenecid.
Potentially Fatal: Admin w/ Ca-containing IV soln may cause precipitation of a crystalline material in the lungs and kidneys.
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