12-24 Hours
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HPC Injection
Popular Pharmaceuticals Ltd.
Generic: Hydroxyprogesterone Caproate
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with HPC Injection. Please consult your doctor.
SAFE IF PRESCRIBED
HPC Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
HPC Injection is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Nonhormonal contraceptives are preferred in breastfeeding women, especially during the first 4 weeks postpartum
SAFE
HPC Injection does not usually affect your ability to drive.
CONSULT YOUR DOCTOR
There is limited information available on the use of HPC Injection in patients with kidney disease. Please consult your doctor.
This medicine contains progesterone which can cause fluid retention in patients with underlying kidney disease.
UNSAFE
HPC Injection is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
Medicine Overview of HPC Injection 250mg/ml Ampoule
Introduction
HPC Injection is used to prevent premature labor in pregnant women in order to reduce the risk of giving birth too early (preterm birth). It prevents miscarriage and lower the risk of premature birth in women who have had one premature delivery in the past. HPC Injection is administered only by or under the supervision of doctor. It should be taken as your doctor advice. Your doctor will decide how much you need to take and for how much time. You should take this injection for as long as it is prescribed for you. The most common side effects of...
... Show moreUses of HPC Injection
- Premature Labor
Side effects of HPC Injection
Common
- Nausea
- Itching
- Diarrhea
- Hives
- Nodules
How to use HPC Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How HPC Injection works
HPC Injection is a progestin (female hormone). It works by modulating the immune response of the mother to prevent rejection of the embryo and allow its attachment to the uterus. This prevents miscarriage and helps lower the risk of premature birth in women who have had one premature delivery in the past.
Quick Tips
- HPC Injection is used in pregnant women to help lower the risk of giving birth too early (preterm birth).
- It is only given to a woman who has had a preterm delivery in the past.
- It is not for use in women who are pregnant with more than one baby (twins, triplets, etc.).
- It is administered only by or under the immediate supervision of your doctor. Your doctor can start giving you the injection every week between 16 and 20 weeks and continue through week 37, or until you deliver.
- It may affect blood sugar levels. Monitor your blood sugar regularly.
- Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain. These could be symptoms of a serious liver problem.
- Inform your doctor immediately if you have pain in the chest, groin or legs, difficulty with breathing, sudden severe headache, slurred speech, sudden unexplained shortness of breath, a sudden loss of coordination, or vision changes while using this medicine.
Brief Description
Indication
Preterm Labor, Recurrent miscarriage, Amenorrhoea, Abnormal uterine bleeding, Palliative treatment of advanced, inoperable endometrial carcinoma
Administration
IM Administration
Inject IM over 1 minute in upper outer quadrant of the gluteus maximus
Inject IM over 1 minute in upper outer quadrant of the gluteus maximus The solution if viscous and oilyThe solution if viscous and oily
1-mL vial does not contain preservatives and is for single dose use
Once opened, the 5-mL multidose vial must be used within 5 weeks
Adult Dose
Intramuscular Preterm Labor Indicated for prevention of preterm labor in a singleton pregnancy for patients aged 16 years or older who have a history of spontaneous preterm birth 250 mg IM qWeek Initiate between the 16th and 20th week of gestation and ending at the 37th week of gestation or birth (whichever is first) Recurrent miscarriage Adult: 250-500 mg wkly during the 1st half of pregnancy. Amenorrhoea; Abnormal uterine bleeding Adult: Single dose of 375 mg; may repeat at 4-wkly intervals if needed. After 4 days of desquamation, or if there is no bleeding within 21 days after admin of...
... Show moreChild Dose
Safety and efficacy not established
Renal Dose
Not studied in patients with renal impairment
Contraindication
Undiagnosed vaginal bleeding, breast cancer, pregnancy, lactation. Thrombophlebitis, thromboembolic disorders, cerebral apoplexy or a history of these conditions. Markedly impaired liver function.
Mode of Action
Hydroxyprogesterone caproate stimulates luteal actions, changes in uterus and vagina as seen in early pregnancy. It also has prolonged uterotrophic effect. Contractile response of the myometrium to oxytocin is inhibited.
Precaution
Physical examination is advised prior to starting therapy. Hepatic impairment, mental depression. Monitor blood glucose in diabetic patients. Discontinue treatment upon signs of thromboembolic and thrombotic disorders. Discontinue treatment if unexplained, sudden or gradual, partial or complete loss of vision, protopsis, diplopia or papilledema, retinal vascular lesions or migraine occur. Caution when used in patients with conditions that might be worsened by fluid retention (e.g. asthma, seizure disorders, migraine, cardiac or renal dysfunction).
Pregnancy Category Note
No adequate or well-controlled studies in women during first trimester
Interaction
Increased clearance when used with enzyme inducers e.g. carbamazepine and phenytoin. May inhibit metabolism of ciclosporin.
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