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HPR
Pacific Pharmaceuticals Ltd.
Generic: Mefenamic Acid
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with HPR.
CONSULT YOUR DOCTOR
HPR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
HPR is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
HPR may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
HPR should be used with caution in patients with kidney disease. Dose adjustment of HPR may be needed. Please consult your doctor.
Use of HPR is not recommended in patients with severe kidney disease.
CAUTION
HPR should be used with caution in patients with liver disease. Dose adjustment of HPR may be needed. Please consult your doctor.
Medicine Overview of HPR 50mg/5ml Suspension
Introduction
HPR is used in the treatment of moderate to severe pain conditions like menstrual pain, headache, muscle pain, joint pain or dental pain. It effectively alleviates pain and inflammation. HPR should be taken with food. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep taking the medicine even if you feel better until the doctor says it is alright to stop using it. The most common side effects of this medicine include mild vomiting, stomach pain, nausea, headache, and dizziness. If any of these side effects...
... Show moreUses of HPR
- Pain relief
Side effects of HPR
Common
- Vomiting
- Nausea
- Indigestion
- Diarrhea
- Loss of appetite
How to use HPR
Take this medicine in the dose and duration as advised by your doctor. Dissolve it in a glass of water before taking it. HPR is to be taken with food.
How HPR works
HPR is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling).
Quick Tips
- It should be taken with food or milk to avoid getting an upset stomach.
- It can cause serious complications like stomach bleeding and kidney problems if taken for a long time.
- Meftal 250mg Tablet DT can raise your risk of blood clots, heart attack, or a stroke.
- Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
- Inform your doctor if you have ever been diagnosed with kidney or liver problems.
Brief Description
Indication
Rheumatoid arthritis, Osteoarthritis, Dysmenorrhoea, Menorrhagia, Dental pain, Pain and inflammation, Mild to moderate pain, Postoperative pain
Administration
Should be taken with food.
Adult Dose
Oral
Rheumatoid arthritis; Mild to moderate pain; Dental pain; Postoperative pain; Dysmenorrhoea; Osteoarthritis; Menorrhagia
Adult: 250-500 mg upto 3 times daily for 3-7 days. Max. 1.5 gm total.
Child Dose
Oral
Rheumatoid arthritis; Mild to moderate pain; Dental pain; Postoperative pain; Dysmenorrhoea; Osteoarthritis; Menorrhagia
Child: >6 mth 25 mg/kg daily in divided doses for up to 7 days.
Contraindication
Hypersensitivity to mefenamic acid, aspirin or other NSAIDs. Patient w/ inflammatory bowel disease, active ulceration or chronic inflammation of the upper or lower GI tract, renal failure. History of asthma, urticaria, allergic-type reactions. Treatment of perioperative pain in the setting of CABG surgery, pregnancy (3rd trimester), lactation. Coronary artery bypass graft surgery, severe renal impairment, severe heart failure.
Mode of Action
Mefenamic acid, an anthranilic acid derivative, is a prototypical NSAID. It reversibly inhibits the cyclooxygenase-1 and -2 (COX-1 and -2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors. It has analgesic and antipyretic properties w/ minor anti-inflammatory activity.
Precaution
Patient w/ known CV disease or risk factors for CV disease, history of GI bleeding or peptic ulceration, fluid retention or heart failure. Renal and hepatic impairment. Anemia, bronchospasm, HTN, SLE, fluid retention, bleeding diathesis. Pregnancy and lactation.
Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor CBC, chemistry profile, hepatic and renal function during long-term therapy. BP should be monitored closely during initiation and throughout therapy.
Lactation: contraindicated; excreted in breast milk
Side Effect
>10%
Borderline elevations of one or more LFTs (<15%)
1-10%
Abdominal pain,Anorexia,Diarrhea,Nausea,Pyrosis,Gastritis,Flatulence,Constipation,Steatorrhea,Upper GI ulcers, gross bleeding/perforation (1% of patients treated for 3-6 mth and 2-4% of those treated for 1 yo)
<1%
Leukopenia,Eosinophilia,Thrombocytopenic purpura,Agranulocytosis,Pancytopenia,Bone marrow hypoplasia,Renal failure (including papillary necrosis & acute interstitial nephritis),Acute interstitial nephritis has been associated with hematuria, proteinuria, & nephrotic syndrome
Potentially Fatal: Autoimmune haemolytic anaemia; convulsions (overdosage).
Pregnancy Category Note
Pregnancy Category: C; D in 3rd trimester or near delivery.
Interaction
Concomitant use w/ CYP2C9 isoenzyme inhibitors may alter safety and efficacy of mefenamic acid. May enhance methotrexate toxicity. Reduced BP response to ACE inhibitors or angiotensin II receptor antagonists. Increased risk of serious GI events w/ aspirin. May reduce the natriuretic effects of furosemide or thiazide diuretics. Reduced renal lithium clearance and elevated plasma lithium levels. May enhance anticoagulant effect of warfarin.
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