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Safety Advices
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CAUTION
Caution is advised when consuming alcohol with Hydrocortisone. Please consult your doctor.
CONSULT YOUR DOCTOR
Hydrocortisone may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Hydrocortisone is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
SAFE
Hydrocortisone does not usually affect your ability to drive.
None stated
SAFE IF PRESCRIBED
Hydrocortisone is safe to use in patients with kidney disease. No dose adjustment of Hydrocortisone is recommended.
However, talk to your doctor if you have any underlying kidney disease.
CONSULT YOUR DOCTOR
There is limited information available on the use of Hydrocortisone in patients with liver disease. Please consult your doctor.
Medicine Overview of Hydrocortisone 100mg/2ml Injection
Introduction
Hydrocortisone belongs to a group of medicines called corticosteroids. It is used to treat a variety of diseases and conditions such as severe allergic reactions, allergic conditions, cancer, and skin and eye disorders. Hydrocortisone is best taken with food. This will prevent you from getting upset stomach. You need to take it regularly to get the maximum benefit of the medicine. Do not stop taking this medicine without speaking to your doctor as it may worsen your symptoms. This medicine is generally safe with little or no side effects. However, it may cause dizziness, headaches, swollen ankles and, weakness. Taking...
... Show moreUses of Hydrocortisone
- Severe allergic reactions
- Allergic conditions
- Cancer
- Skin disorders
- Eye disorders
Side effects of Hydrocortisone
Common
- Ankle swelling
How to use Hydrocortisone
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Hydrocortisone is to be taken with food.
How Hydrocortisone works
Hydrocortisone is a steroid which works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies.
Quick Tips
- Hydrocortisone helps treat inflammation, severe allergies, flare-ups of ongoing illnesses, and many other medical problems that require either reduction of inflammation or suppression of the immune system.
- Do not use it more often or for longer than advised by your doctor.
- Take it with food to avoid an upset stomach.
- Hydrocortisone can make it harder for you to fight off infections. Notify your doctor if you have any signs of infection such as a fever or sore throat.
- Side effects such as mood changes or stomach problems can happen when you start taking Hydrocortisone. Inform your doctor if this bothers you.
- Do not stop taking Hydrocortisone suddenly without talking to your doctor first as it may worsen your symptoms.
Brief Description
Indication
Corticosteroid-responsive dermatoses, hypersensitivity reactions such as, angioedema, status asthmaticus, Soft tissue inflammation, Joint inflammations, Primary or secondary adrenocortical insufficiency, Acute adrenocortical insufficiency, Shock unresponsive to conventional therapy, Congenital adrenal hyperplasia, Hypercalcemia associated with cancer, Nonsuppurative thyroiditis, Rheumatic Disorders, Dermatologic Diseases, (Allergic States, Severe seborrheic dermatitis, Severe psoriasis, Pemphigus, Severe erythema multiforme), Control of severe or incapacitating allergic conditions, (Bronchial asthma, Contact dermatitis, Atopic dermatitis, Serum sickness, Seasonal or perennial allergic rhinitis, Drug hypersensitivity reactions, Urticarial transfusion reactions, Acute noninfectious laryngeal edema), Ophthalmic Diseases, (Herpes zoster ophthalmicus, Iritis, iridocyclitis, Chorioretinitis, Diffuse posterior uveitis and choroiditis, Optic neuritis), Gastrointestinal Diseases, Fulminating or...
... Show moreAdministration
Should be taken with food.
Adult Dose
Oral Replacement therapy in adrenocortical insufficiency Adult: 20-30 mg daily in 2 divided doses. Intravenous As supplement in adrenal insufficiency during minor surgery under general anaesthesia Adult: In patients taking >10 mg of prednisolone or its equivalent by mouth daily. 25-50 mg at induction. Resume with usual oral corticosteroid after surgery. As supplement in adrenal insufficiency during moderate or major surgery Adult: In patients taking >10 mg of prednisolone or its equivalent by mouth daily. Usual oral corticosteroid dose on the morning of the surgery followed by 25-50 mg at induction, then similar doses of hydrocortisone tid for 24 hr...
... Show moreChild Dose
Oral
Replacement therapy in adrenocortical insufficiency
Child: 400-800 mcg/kg/day, in 2-3 divided doses.
Intravenous
Acute adrenocortical insufficiency
Child: <1 yr: 25 mg;
1-5 yr: 50 mg;
6-12 yr: 100 mg.
Fluids and electrolytes should be administered as needed to correct any metabolic disorder. Doses may also be given via IM inj but the response may be slower.
Status Asthmaticus
1-2 mg/kg IV q6hr for 24 hr; not to exceed 250 mg
IV Maintenance: 2 mg/kg/day IV divided q6hr
Contraindication
Viral/fungal infections, tubercular or syphilitic lesions, bacterial infections unless used in conjunction with appropriate chemotherapy.
Mode of Action
Hydrocortisone is a corticosteroid used for its anti-inflammatory and immunosuppressive effects. Its anti-inflammatory action is due to the suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It may also be used as replacement therapy in adrenocortical insufficiency.
Precaution
CHF, hypertension, DM, epilepsy, elderly, patients on prolonged therapy. Gradual withdrawal, pregnancy and lactation.
Lactation: Drug enters breast milk; use with caution
Side Effect
Sodium and fluid retention. Potassium and calcium depletion. Muscle wasting, weakness, osteoporosis. GI disturbances and bleeding. Increased appetite and delayed wound healing. Bruising, striae, hirsutism, acne, flushing. Raised intracranial pressure, headache, depression, psychosis, menstrual irregularities. Hyperglycaemia, glycosuria, DM, obesity, moon-face, buffalo hump. Suppression of pituitary-adrenocortical system. Growth retardation in childn (prolonged therapy). Increased susceptibility for infection. Topical use: Dermal atrophy, local irritation, folliculitis, hypertrichosis. Inhaled corticosteroids: May cause hoarseness, candidiasis of mouth and throat. Topical application to the eye: Can produce corneal ulcers, raised IOP and reduced visual function. Intralesional injection: Local hypopigmentation of deeply pigmented skin. Intra-articular injection: Joint...
... Show moreInteraction
Thiazides may enhance hyperglycaemia and hypokalaemia caused by corticosteroids. Increased incidence of peptic ulcer or GI bleeding with concurrent NSAIDs admin. Response to anticoagulants altered. Dose of antidiabetics and antihypertensives needs to be increased. Decreases serum conc of salicylates and antimuscarinic agents. Ethanol may enhance gastric mucosal irritation.
Reduced efficacy with concurrent use of carbamazepine, phenytoin, primidone, barbiturates and rifampicin. Mutual inhibition of metabolism between ciclosporin and corticosteroids increase plasma conc of both drugs. Enhanced effect in women taking oestrogens or oral contraceptives.
