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Indoxyl
Jayson Pharmaceuticals Ltd.
Generic: Indomethacin
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Indoxyl.
CONSULT YOUR DOCTOR
Indoxyl is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Indoxyl is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Indoxyl may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Indoxyl is safe to use in patients with kidney disease. No dose adjustment of Indoxyl is recommended.
However, a regular monitoring of kidney function test and potassium levels is advised while you are taking this medicine. Please consult your doctor.
CAUTION
Indoxyl should be used with caution in patients with liver disease. Dose adjustment of Indoxyl may be needed. Please consult your doctor.
Medicine Overview of Indoxyl 25mg Capsule
Introduction
Indoxyl helps in relieving moderate pain and reducing fever. It effectively alleviates pain and inflammation in conditions like rheumatoid arthritis, osteoarthritis, gout and ankylosing spondylitis. Indoxyl should be taken in the dose and duration as advised by your doctor. It should be taken with food or milk to prevent stomach upset. Inform your doctor if you have any history of heart disease or stroke. Vomiting, stomach pain, nausea and indigestion are some of the common side effects that might be observed on taking this medicine. It may also cause dizziness, drowsiness or visual disturbances. Your doctor may regularly monitor your...
... Show moreUses of Indoxyl
- Pain relief
Side effects of Indoxyl
Common
- Vomiting
- Stomach pain/epigastric pain
- Nausea
- Indigestion
- Diarrhea
- Heartburn
- Loss of appetite
How to use Indoxyl
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Indoxyl is to be taken with food.
How Indoxyl works
Indoxyl is a non-steroidal anti-inflammatory drugs (NSAID). It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling).
Quick Tips
- You have been prescribed Indoxyl to relieve pain and inflammation.
- Take it with food or milk to prevent upset stomach.
- Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems.
- It may cause dizziness, drowsiness or visual disturbances. Use caution while driving or doing anything that requires concentration.
- Avoid consuming alcohol while taking Indoxyl as it can cause excessive drowsiness and increase your risk of stomach problems.
- Inform your doctor if you have a history of heart disease or stroke.
- Your doctor may regularly monitor your kidney function, liver function and levels of blood components, if you are taking this medicine for long-term treatment.
Brief Description
Indication
Rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis (degenerative joint disease), gout, acute non-articular rheumatism (bursitis, synovitis, tendinitis).
Administration
Take with food to avoid gastrointestinal (GI) effects
Adult Dose
Oral
Inflammatory/Rheumatoid Disorders
Immediate release: 25-50 mg PO q8-12hr; not to exceed 200 mg/day
Extended release: 75-150 mg/day PO in single daily dose or divided q12hr; not to exceed 150 mg/day
Bursitis/Tendinitis
Immediate-release: 75-150 mg/day PO divided q6-8hr
Extended-release: 75-150 mg/day PO in single daily dose or divided q12hr
Acute Gouty Arthritis
50 mg PO q8hr for 3-5 days; reduced once pain is under control
Rectal
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: As supp: 100 mg to be inserted at night and repeated in the morning if necessary.
Child Dose
Inflammatory/Rheumatoid Disorders
14 years: 25-50 mg IR PO q8-12hr; not to exceed 200 mg/day;
75-150 mg/day ER PO in single daily dose or divided q12hr; not to exceed 150 mg/day
Contraindication
Indomethacin is contraindicated in patients with ulcer, gastritis, active ulcerative colitis, and should be used with caution in patients with a history of these disorders. It is also contraindicated in previously hypersensitive patient.
Mode of Action
Indometacin, an indole acetic acid derivative has anti-inflammatory, analgesic and antipyretic actions. It reversibly inhibits cyclooxygenase-1 and -2 (COX-1 and -2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors.
Precaution
Patient w/ known CV disease or risk factors for CV disease, fluid retention, history of GI disease (e.g. bleeding or ulcers), history of mental depression or other psychiatric disorder, epilepsy, or parkinsonian syndrome; existing infection that is adequately controlled. May mask signs and symptoms of infection. Hepatic and renal impairment. Elderly, childn. Pregnancy and lactation.
Lactation: Drug enters breast milk; use not recommended (American Academy of Pediatrics committee states that drug is compatible with nursing)
Side Effect
>10%
Transient renal insufficiency (40%),Jaundice (<15%),Elevated liver function test values (≤15%),Headache (12%)
1-10%
Dizziness (3-9%),Dyspepsia (3-9%),Epigastric pain (3-9%),Indigestion (3-9%),Nausea (3-9%)
Symptomatic upper GI ulcers, gross bleeding/perforation (4% of patients treated for 1 year; 1% of patients treated for 3-6 months).
Abnormal pain/cramps/distress (<3%),Constipation (1-3%),Depression (1-3%),Diarrhea (1-3%),Fatigue (1-3%),Somnolence (1-3%),Tinnitus (1-3%),Vertigo (1-3%)
<1%
Acute interstitial nephritis with hematuria/proteinuria,Acute respiratory distress,Agranulocytosis,Angioedema,Aplastic anemia,Asthma,Bone marrow depression,Congestive heart failure (CHF),Hemolytic anemia,Leukopenia,Macular and morbilliform eruptions,Pulmonary edema,Thrombocytopenia,Thrombocytopenic purpura,Ulcerative stomatitis,Urticaria
Interaction
May increase plasma levels of methotrexate. Increased risk of GI bleeding w/ warfarin. May reduce hypotensive effects of hydralazine, furosemide, ?-blockers (e.g. atenolol, propranolol, oxprenolol), or thiazide diuretics. Increased risk of hyperkalaemia w/ K-sparing diuretics, ACE inhibitors, K supplements. May increase nephrotoxic effects of ciclosporin or triamterene. Increase plasma concentration w/ probenecid. May increase plasma levels of aminoglycoside (e.g. amikacin, gentamicin) in premature neonates. May enhance antipsychotic effect (e.g. severe drowsiness and confusion) of haloperidol. Al- or Mg-containing antacids may reduce GI disorders of indometacin. Potentially Fatal: Diflunisal decreases renal clearance and increases plasma concentrations of indometacin which leads to...
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