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Integril 2
Incepta Pharmaceuticals Ltd.
Generic: Eptifibatide
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Integril 2. Please consult your doctor.
SAFE IF PRESCRIBED
Integril 2 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
CAUTION
Integril 2 should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
NOT RELEVANT
Not relevant, as Integril 2 is intended for use in hospitalised patients.
CAUTION
Integril 2 should be used with caution in patients with kidney disease. Dose adjustment of Integril 2 may be needed. Please consult your doctor.
Use of Integril 2 is not recommended in patients with severe kidney disease.
CONSULT YOUR DOCTOR
There is limited information available on the use of Integril 2 in patients with liver disease. Please consult your doctor.
Use of Integril 2 is not recommended in patients with severe liver disease.
Medicine Overview of Integril 2 20mg/10ml Injection
Introduction
Integril 2 is a blood thinner which prevents formation of harmful blood clots. It is used in the treatment of a heart attack and also prevents the clotting of blood in the heart during an angioplasty (procedure to improve blood flow to the heart). Integril 2 is administered under the supervision of a doctor. Your doctor will decide the dose and duration of the medicine for you. You should continue all your other medicines that are advised by the doctor for your long-term treatment even after this injection. Use of this medicine may cause low blood platelets and increase your...
... Show moreUses of Integril 2
- Heart attack
Side effects of Integril 2
Common
- Bleeding
- Decreased blood pressure
How to use Integril 2
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Integril 2 works
Integril 2 is an antiplatelet medication. It works by preventing the platelets from sticking together, thereby decreasing the formation of harmful blood clots.
What if you forget to take Integril 2?
If you miss a dose of Integril 2, please consult your doctor.
Quick Tips
- It is usually given by your nurse or doctor as an infusion (drip) into a vein.
- It increases your risk of bleeding. Be careful while shaving, cutting fingernails or toenails or using sharp objects.
- Notify your doctor if you see blood in your vomit, urine or stool (black, tarry stools or bright red blood).
Brief Description
Indication
Myocardial infarction, Unstable angina, Angioplasty, Percutaneous coronary intervention (PCI)
Adult Dose
Intravenous Unstable angina Adult: 180 mcg/kg via IV inj followed by 2 mcg/kg per minute by IV infusion for up to 72 hr. If percutaneous coronary intervention (PCI) is performed during therapy, infusion should be continued for 18-24 hr after procedure, up to a maximum total duration of 96 hr of therapy. Angioplasty Adult: Initially, 180 mcg/kg via IV inj, to be given immediately before procedure, followed by 2 mcg/kg/minute via IV infusion. A second dose of 180 mcg/kg via IV inj should be given 10 minutes after the 1st dose. Continue infusion until hospital discharge or for up to...
... Show moreRenal Dose
Renal Impairment
(CrCl <50 mL/min)
ACS: 180 mcg/kg IV, THEN continuous infusion 1 mcg/kg/min
PCI: 180 mcg/kg IV, THEN continuous infusion 1 mcg/kg/min with another 180 mcg/kg IV bolus 10 minutes after 1st one
Hemodialysis: Safety and using during hemodialysis not established
Contraindication
Active bleeding, increased risk of haemorrhage including hemorrhagic disorders, cerebrovascular disorders, history of stroke, uncontrolled hypertension, severe trauma, severe renal impairment, recent major surgery. Lactation.
Mode of Action
Eptifibatide is a cyclic heptapeptide which blocks the platelet glycoprotein IIb/IIIa receptor thus preventing platelet aggregation and thrombosis.
Precaution
Discontinue in case of serious uncontrolled bleeding, or if emergency surgery or thrombolytic therapy is required. Hepatic impairment, platelet counts <100,000 mm3; hemorrhagic retinopathy, drugs affecting haemostasis. Check APTT or ACT prior to sheath removal. Severe renal impairment, vasculitis, haemorrhagic retinopathy, acute pericarditis or aortic dissection. Pregnancy.
Lactation: excretion in milk unknown; use with caution
Side Effect
1-10%
Bleeding (8%),Hypotension (7%),Thrombocytopenia (2.3%),Injection site reaction
<1%
Hypersensitivity,Intracranial hemorrhage,Pulmonary hemorrhage,Thrombocytopenia,GI hemorrhage
Pregnancy Category Note
Pregnancy Category: B
Lactation: excretion in milk unknown; use with caution
Interaction
Increased risk of bleeding w/ heparin, other anticoagulants, antiplatelet & thrombolytic agents.
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