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Safety Advices
বাংলা
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UNSAFE
Irbes may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Irbes is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Irbes is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
CONSULT YOUR DOCTOR
It is not known whether Irbes alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
SAFE IF PRESCRIBED
Irbes is safe to use in patients with kidney disease. No dose adjustment of Irbes is recommended.
However, inform your doctor if you have an underlying kidney disease.
SAFE IF PRESCRIBED
Irbes is safe to use in patients with liver disease. No dose adjustment of Irbes is recommended.
However, there is limited information available on use of Irbes in patients with severe liver disease. Please inform your doctor.
Medicine Overview of Irbes 75mg Tablet
Introduction
Irbes is a medicine used to treat high blood pressure and heart disease. Lowering blood pressure helps to prevent future heart attack and stroke. This medicine is also effective in preserving kidney function in patients with diabetes. Irbes can be prescribed either alone or in combination with other medicines. It may be taken with or without food during the day or at night. However, try to take it at the same time each day to get the most benefit. It is important to continue taking it regularly even if you feel well or if your blood pressure is controlled. Most...
... Show moreUses of Irbes
- Hypertension (high blood pressure)
Side effects of Irbes
Common
- Dizziness
- Increased potassium level in blood
How to use Irbes
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Irbes may be taken with or without food, but it is better to take it at a fixed time.
How Irbes works
Irbes is an angiotensin receptor blocker (ARB). It relaxes the blood vessel by blocking the action of a chemical that usually makes blood vessels tighter. This lowers the blood pressure, allowing the blood to flow more smoothly to different organs and the heart to pump more efficiently.
What if you forget to take Irbes?
If you miss a dose of Irbes, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- It can make you feel dizzy for the first few days. Rise slowly if you have been sitting or lying down for a long time.
- Your doctor may get regular tests done to monitor the level of urea, creatinine, and potassium in your blood.
- Avoid taking anti-inflammatory medicines such as ibuprofen along with this medicine without consulting your doctor.
- Do not take Irbes if you are pregnant or breastfeeding.
- Do not stop taking it suddenly without talking to your doctor.
Brief Description
Indication
Diabetic nephropathy, Hypertension
Administration
May be taken with or without food.
Adult Dose
Oral
Hypertension
Adult: 150 mg once daily, may increase to 300 mg once daily if needed. Patient w/ intravascular volume depletion: Initially, 75 mg once daily.
Elderly: >75 yr Initially, 75 mg once daily.
Diabetic nephropathy in Type 2 diabetes mellitus
Adult: Initially, 75-150 mg once daily, may increase to 300 mg once daily if needed.
Child Dose
Hypertension
12 years: 150 mg/day PO initially; may be increased to 300 mg/day PO
Renal Dose
Renal impairment:
Haemodialysis: Initially, 75 mg once daily.
Mild-to-severe renal impairment: Dosage adjustment not necessary unless patient is hypovolemic
Contraindication
Hypersensitivity; pregnancy and lactation.
Mode of Action
Irbesartan is an angiotensin II receptor antagonist. It blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II by binding to AT1 receptors.
Precaution
Child <6 yr. Unilateral or bilateral renal artery stenosis; vol or Na depletion; aortic or mitral valve stenosis, hypertrophic cardiomyopathy.
Lactation: Potential harm to nursing infant; discontinue drug, or do not nurse
Side Effect
>10%
Hyperkalemia (19%)
1-10%
Dizziness (10%),Upper respiratory tract infection (URTI) (9%),Orthostatic hypotension (5%),Fatigue (4%),Diarrhea (3%),Dyspepsia (2%)
Pregnancy Category Note
Pregnancy category: 1st trimester, C; 2nd and 3rd trimesters, D
Interaction
May antagonise hypotensive effect and increase risk of nephrotoxicity w/ NSAIDs. May increase serum lithium levels and toxicity. Increased risk of hyperkalaemia w/ K-sparing diuretics (e.g. amiloride, triamterene, spironolactone), K supplements or K-containing salt substitutes.
Potentially Fatal: May increase nephrotoxic, hyperkalaemic and hypotensive effect w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min).
