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Irinox
Beacon Pharmaceuticals PLC
Generic: Irinotecan Hydrochloride Trihydrate
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Irinox. Please consult your doctor.
CONSULT YOUR DOCTOR
Irinox is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Irinox is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Irinox may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Irinox is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Irinox may not be needed in these patients. Please consult your doctor.
Use of this medicine is not recommended for patients on dialysis.
CONSULT YOUR DOCTOR
There is limited information available on the use of Irinox in patients with liver disease. Please consult your doctor.
Medicine Overview of Irinox 20mg/ml Injection
Introduction
Irinox is used in the treatment of cancer of colon and rectum. It shows its working by stopping or slowing down the growth of cancer cells. Irinox is given as an IV infusion into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It...
... Show moreUses of Irinox
- Cancer of colon and rectum
Side effects of Irinox
Common
- Fatigue
- Nausea
- Vomiting
- Weakness
- Hair loss
- Fever
- Anemia (low number of red blood cells)
- Diarrhea
- Decreased white blood cell count (neutrophils)
- Decreased appetite
- Mucosal inflammation
How to use Irinox
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Irinox works
Irinox is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase I) involved in DNA multiplication of the cancer cells. This slows the growth of cancer cells and eventually kills them.
What if you forget to take Irinox?
If you miss a dose of Irinox, please consult your doctor.
Quick Tips
- Irinox is used in combination with other medicines for the treatment of metastatic cancer of the colon and rectum.
- It is given via a drip into a vein (intravenous infusion).
- It may cause dizziness and visual disturbances. Do not drive or do anything that requires mental focus until you know how it affects you.
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
- Your doctor may get regular blood tests done to monitor your blood cells, kidney and liver function during treatment with this medicine.
- Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
- Inform your doctor if you notice passage of blood in stools or experience dizziness or faintness, continuous episodes of nausea, vomiting, diarrhea or fever.
Brief Description
Indication
Carcinoma of the colon or rectum
Administration
Reconstitution: Dilute in 5% dextrose injection (preferred) or 0.9% sodium chloride injection to a final concentration of 0.12-2.8 mg/ml.
Adult Dose
Intravenous Colorectal Cancer Indicated as first-line therapy (with 5-fluorouracil and leucovorin) for metastatic colorectal cancer (CRC); it is also indicated for CRC that has recurred or progressed following intial fluorouracil-based therapy Monotherapy Patients should be premedicated with antiemetic agents Atropine treatment should be considered in patients that experience cholinergic symptoms Regimen 1 (Weekly): 125 mg/m² IV infusion over 90 minutes on days 1, 8, 15, 22, then 2 weeks off, then repeat Regimen 2 (Once Every 3 Weeks): 350 mg/sq.meter IV infusion over 30-90 minutes q3Weeks Adjust dose per protocol Combination therapy Patients should be premedicated with antiemetic agents Atropine...
... Show moreChild Dose
Not recommended
Contraindication
Patients with a known hypersensitivity to the drug or its excipients.
Mode of Action
Irinotecan, a derivative of camptothecin, works by inhibiting the enzyme topoisomerase I thereby interfering with the coiling and uncoiling of DNA during replication and causing irreparable damage.
Precaution
Early diarrhea is usually transient and infrequently severe. It may be accompanied by cholinergic symptoms of rhinitis, increased salivation, miosis, lacrimation, diaphoresis, flushing, and intestinal hyperperistalsis that can cause abdominal cramping. Bradycardia may also occur.
Late diarrhea can be life threatening since it may be prolonged and may lead to dehydration, electrolyte imbalance, or sepsis.Late diarrhea can be complicated by colitis, ulceration, bleeding, ileus, obstruction, and infection. Cases of megacolon and intestinal perforation have been reported.
Lactation: not known if excreted in breast milk, do not nurse
Side Effect
>10%
Anemia (>90%),Leukopenia (>90%),Neutropenia (>90%),Thrombocytopenia (>90%),Elevated bilirubin (88%),Diarrhea (85%),Nausea (79%),Asthenia (70%),Abdominal pain (63%),Vomiting (60%),Alopecia (43%),Fever (42%),Constipation (41%),Anorexia (34%),Mucositis (32%),Pain (31%),Dyspnea (28%),Cough (27%),Dizziness (23%),Infection (22%),Rash (19%)
1-10%
Abdominal fullness (10%),AST increased (10%),Dyspepsia (10%),,Edema (10%),Ascites/jaundice (9%),Vasodilation (9%),Thromboembolism (9%),Hypotension (6%),Neutropenic fever (2-6%)
Frequency Not Defined
Headache,Insomnia,Orthostatic hypotension
Potentially Fatal: Fatal sepsis due to myelosuppression; severe, chronic diarrhoea.
Interaction
Diuretics increase risks of dehydration secondary to vomiting/diarrhoea; prophylactic dexamethasone as an antiemetic may enhance lymphocytopenia; prochlorperazine may increase incidence of akathisia; antineoplastic agents (myelosuppression and diarrhoea). St John's wort, ketoconazole may reduce irinotecan exposure.
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