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Isotrex
Glaxo SmithKline Pharmaceuticals Ltd
Generic: Isotretinoin 0.05% Topical
Safety Advices
বাংলা
English
UNSAFE
Isotrex is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
CONSULT YOUR DOCTOR
Isotrex is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Medicine Overview of Isotrex 0.05mg/100ml Gel
Introduction
Isotrex belongs to a group of medicines known as retinoids that are used to treat severe acne, which occur as pimples, in adults and adolescents from 12 years of age only after puberty. This medicine is for patients whose acne has not responded to other treatments. Isotrex reduces excessive oil production of the skin. Ideally, a pinpoint application at night time is recommended for a duration as prescribed by the doctor. The amount you need, and how long you take it will depend on what you are being treated for. You should normally wash and dry the affected area before...
... Show moreUses of Isotrex
- Acne
Side effects of Isotrex
Common
- Application site reactions (burning, irritation, itching and redness)
- Dry skin
- Cracked lips
How to use Isotrex
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area.
How Isotrex works
Isotrex is a derivative of vitamin A. It acts on glands (sebaceous) on your skin to reduce the production of a natural substance (sebum) that causes acne. Also, the controlled sebum production kills acne-causing bacteria. It also works as an anti-inflammatory to decrease inflammation (redness and swelling).
What if you forget to take Isotrex?
If you miss a dose of Isotrex, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- You have been prescribed Isotrex for the treatment of acne.
- Clean the area to be treated with water and a non-medicated soap, and let it dry for 20-30 minutes before applying Isotrex.
- It may increase the severity of the lesions in the first few weeks of use. Continue using it as prescribed by your doctor.
- It may cause stinging sensation or a feeling of warmth when you first start using it. Inform your doctor if this persists.
- Avoid exposure to sunlight while using it as it increases the sensitivity of your skin. Use protective measures such as sun-cream or protective clothing.
- Avoid face waxing and laser treatment while using this medicine as it makes your skin more fragile.
- Do not use Isotrex if you are pregnant or breastfeeding.
- Inform your doctor if excessive skin dryness or skin sensitivity take place.
Brief Description
Indication
Acne
Adult Dose
Topical/Cutaneous
Acne
Adult: As 0.05% gel: Apply sparingly once or twice daily. Effect is observed w/in 6-8 wk of treatment.
Contraindication
Pregnancy, lactation.
Mode of Action
Isotretinoin is a synthetic retinoid which reduces sebaceous gland size and sebum production. It also regulates cell proliferation and differentiation.
Precaution
Preexisting or predisposition to hypertriglyceridaemia (e.g. DM, obesity or increased alcohol intake). Monitor triglyceride levels. Monitor blood lipids and LFTs at wkly or bi-wkly intervals. Monitor blood glucose in known or suspected DM patients. Genetic predisposition for age-related osteoporosis, history of childhood osteoporosis, osteomalacia or other bone metabolism disorders. Anorexia nervosa. History of psychiatric disorder. May impair night vision. Avoid wax epilation and skin resurfacing procedures for at least 6 mth. Avoid prolonged exposure to UV light or sunlight. Discontinue if hearing impairment, abdominal pain, rectal bleeding, severe diarrhoea or adverse ocular effects occur. Patient should not donate blood during...
... Show moreSide Effect
Dryness of mucous membranes, dryness of skin with scaling, fragility, erythema, cheilitis, pruritus, epistaxis, conjunctivitis, dry sore mouth and palmo-plantar exfoliation. Corneal opacities, dry eyes, visual disturbances, skeletal hyperostosis and musculoskeletal symptoms. Elevation of serum triglycerides, LFTs, ESR and blood glucose. Hair thinning, photosensitivity, changes in skin pigmentation, paronychia. GI disturbances, hepatitis. Headache, drowsiness, sweating, mood changes, psychotic symptoms, depression, suicidal tendencies, benign intracranial hypertension, seizures. Vasculitis, hypersensitivity reactions, IBS.
Potentially Fatal: Anaphylaxis. Haemorrhagic pancreatitis.
Interaction
Additive toxicity with vitamin A or its derivatives. Decreased efficacy of microdosed progesterone (use 2 forms of contraception). May increase risk of bone loss with phenytoin. May increase risk of osteoporosis with systemic corticosteroids. Reduces plasma levels of carbamazepine.
Potentially Fatal: Increased risk of pseudotumor cerebri with tetracyclines.
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