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Safety Advices
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SAFE
Consuming alcohol with Amoclav 375 does not cause any harmful side effects.
SAFE IF PRESCRIBED
Amoclav 375 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Amoclav 375 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Amoclav 375 may cause side effects which could affect your ability to drive.
Amoclav 375 may cause side effects such as allergic reactions, dizziness or fits that may make you unfit to drive.
CAUTION
Amoclav 375 should be used with caution in patients with kidney disease. Dose adjustment of Amoclav 375 may be needed. Please consult your doctor.
Use of this medicine is not recommended in patients with severe kidney disease.
CAUTION
Amoclav 375 should be used with caution in patients with liver disease. Dose adjustment of Amoclav 375 may be needed. Please consult your doctor.
Regular monitoring of liver function tests is recommended while you are taking this medicine
Medicine Overview of Amoclav 375 250mg+125mg Tablet
Introduction
Amoclav 375 is a penicillin-type of antibiotic that helps your body fight infections caused by bacteria. It is used to treat infections of the lungs (e.g., pneumonia), ear, nasal sinus, urinary tract, skin and soft tissue. It will not work for viral infections such as the common cold. Amoclav 375 is best taken with a meal to reduce the chance of a stomach upset. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will...
... Show moreUses of Amoclav 375
- Bacterial infections
Side effects of Amoclav 375
Common
- Vomiting
- Nausea
- Diarrhea
How to use Amoclav 375
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Amoclav 375 is to be taken with food.
How Amoclav 375 works
Amoclav 375 is a combination of two medicines: Amoxycillin and Clavulanic Acid. Amoxycillin is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Clavulanic Acid is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Amoxycillin against bacteria.
What if you forget to take Amoclav 375?
If you miss a dose of Amoclav 375, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- You have been prescribed this combination medicine to treat bacterial infections even if they have developed resistance.
- Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
- Diarrhea may occur as a side effect. Taking probiotics along with Amoclav 375 may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
- Take it with food and plenty of fluids to avoid an upset stomach.
- Stop taking Amoclav 375 and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.
- Do not use leftover medicine for treating any infection in the future. Always consult your doctor before taking any antibiotic.
Brief Description
Indication
Adults: PO: One 375 mg tablet 3 times a day. In severe infection one 625mg tablet 3 times a day or one 1gm tablet two times a day.
IV Injection: 1.2 g every 6-8 hours
Hepatic impairment: Dose with caution; monitor hepatic function regularly
Administration
Allopurinol may reduce renal tubular secretion of amoxicillin thus increasing the serum levels of amoxicillin. Concurrent use may reduce the efficacy of oral contraceptives.
Adult Dose
History of allergy especially to cephalosporins, infectious mononucleosis, severe renal impairment.
Lactation: Drug excreted in breast milk; use caution
Renal Dose
Clavulanic acid has a high affinity for and binds to certain ?-lactamases that generally inactivate amoxicillin by hydrolyzing its ?-lactam ring. Combining clavulanate potassium with amoxicillin extends the antibacterial spectrum of amoxicillin to include many bacteria normally resistant to amoxicillin and other penicillins and cephalosporins.
Contraindication
Children: 125/31.25-, 250/62.5-mg/5-mL susp: 20–40 mg amoxicillin component/kg/day (max 1,500 mg/day) q8h 200/28.5-, 400/57-mg/5-mL susp: 25-45 mg amoxicillin component/kg/day (max 1,750 mg/day) q12h Children of 6-12 years: 2 teaspoonful Powder for Suspension every 8 hours. Children of 1-6 years: 1 teaspoonful Powder for Suspension every 8 hours. Children below 1 year: 25 mg/kg/day in divided doses every 8 hours. Children over 12 years: IV Injection: 1.2 g every 6-8 hours, Children up to 3 months: 30 mg/kg every 8 hours (every 12 hours in the perinatal period and in premature infants); Child 3 months-12 years, 30 mg/kg every 6-8 hours....
... Show moreMode of Action
Take with meals to avoid GI upset
Take suspension at start of meal to enhance absorption
Reconstitution: Powd for inj: Dissolve amoxicillin/clavulanic acid 500/100 mg in 10 mL solvent and 1,000/200 mg in 20 mL solvent. May further dilute to infusion soln containing either water for inj or NaCl 0.9%.
Precaution
Bacterial infections, Acute otitis media, Acute bacterial sinusitis, Endocarditis, Dental abscess, Community-acquired pneumonia, Acute uncomplicated UTI, Uncomplicated gonorrhea, Severe or recurrent resp tract infections
Side Effect
Renal impairment
CrCl <30 mL/min: Do not use 875/125 mg tablet or extended-release tablets
CrCl 10-30 mL/min: 250-500/125 mg PO q12hr
CrCl <10 mL/min: 250-500/125 mg PO q24hr
Hemodialysis: 250-500/125 mg PO q24hr; administer additional dose both during and at end of dialysis
Pregnancy Category Note
>10%
Diarrhea (3-34%; varies upon dose and regimen)
1-10%
Diaper rash (3.5%),Mycosis (3.3%),Nausea (2-3%),Rash (1-3%),Vomiting (1-2.2%),Loose stool (1.6%),Candidiasis (1.4%),Vaginitis (1%)
<1%
Hypersensitivity reactions,Anaphylaxis,Anemia,Thrombocytopenia,Leukopenia,Agranulocytosis,Hepatoxicity,AST/ALT elevation,Pseudomembranous colitis,Serum sickness,Abdominal discomfort,Cholestatic jaundice,Flatulence
Potentially Fatal: Anaphylactic reaction with CV collapse esp with parenteral use.
Interaction
Penicillin allergy.
