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Kezona 200
Eskayef Pharmaceuticals Ltd.
Generic: Ketoconazole
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
Kezona 200 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Kezona 200 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Medicine Overview of Kezona 200mg Tablet
Introduction
Kezona 200 belongs to a group of medicines called antifungals. It is used to treat fungal infections of the skin. It works by killing the fungus that causes infections such as athlete’s foot, thrush and ringworm. Kezona 200 should be used in the dose and duration as prescribed by your doctor. This medicine should be used regularly to get the maximum benefit from it. Do not use more than you need, it will not clear your condition faster and may only increase the side effects. Skin infections will usually get better after 2 to 4 weeks. Do not use the...
... Show moreUses of Kezona 200
- Fungal skin infections
Side effects of Kezona 200
Common
- Application site burning
- Skin peeling
How to use Kezona 200
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.
How Kezona 200 works
Kezona 200 is an antifungal medication. It kills and stops the growth of the fungi by destroying its cell membrane, thereby treating your skin infection.
What if you forget to take Kezona 200?
If you miss a dose of Kezona 200, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- KZ Cream helps treat skin infections caused by many different types of fungi.
- Few healthy tips for Athlete's Foot:
- Apply an amount sufficient to cover the affected area and 1 inch of the immediate surrounding skin.
- Finish the full course of treatment even if you feel better.
- Avoid getting it in the eyes, nose, or mouth. If accidental exposure occurs, rinse immediately with plenty of water.
- Inform your doctor if the infection has not cleared up after 4 weeks of treatment.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Indication
Candidiasis, Fungal infections, Pityriasis versicolor, Seborrhoeic dermatitis
Administration
Should be taken with food.
Adult Dose
Oral
Fungal infections
Adult: 200 mg once daily; may increase to 400 mg once daily if clinical response is insufficient. Continue treatment until symptoms have cleared and cultures have become negative.
Chronic vag candidiasis
400 mg once daily for 5 days.
Elderly: No dosage adjustment needed.
Hepatic impairment: Contraindicated.
Child Dose
Oral
Fungal infections
Child: >2 yr 3.3-6.6 mg/kg/day once daily.
Treatment duration: 1-2 wk for candidiasis; at least 4 wk in recalcitrant dermatophyte infections and up to 6 mth for other systemic mycoses.
Renal Dose
Renal impairment: No dosage adjustment needed.
Contraindication
Hypersensitivity; preexisting liver disease, porphyria. Concurrent use with cisapride, terfenadine or astemizole.
Mode of Action
Ketoconazole interferes w/ biosynthesis of triglycerides and phopholipids by blocking fungal CYP450, thus altering cell membrane permeability in susceptible fungi. It also inhibits other fungal enzymes resulting in the accumulation of toxic concentrations of hydrogen peroxide.
Precaution
Hepatic impairment; monitor liver function regularly. Pregnancy, lactation. Predisposition to adrenocortical insufficiency. Discontinue treatment if there is persistent or worsening of liver enzyme elevation.
Side Effect
1-10%
Nausea and vomiting (3-10%),Pruritus (2%),Abdominal pain (1%)
<1%
Alopecia,Headache,Dizziness,Hyperlipidemia,Somnolence,Fever,Chills,Bulging fontanelles,Depression,Gynecomastia,Diarrhea,Impotence,Thrombocytopenia,Leukopenia,Hemolytic anemia,Erythema multiforme,Orthostatic hypotension,Jaundice,Dyspepsia,Dysgeusia,Hepatotoxicity,Decreased platelet count,Xeroderma,Photophobia
Potentially Fatal: Hepatotoxicity.
Interaction
Reduced absorption w/ antimuscarinics, antacids, H2-blockers, PPIs, sucralfate. Reduced plasma concentrations w/ rifampicin, isoniazid, efavirenz, nevirapine, phenytoin. May also reduce concentrations of isoniazid and rifampicin. May reduce efficacy of oral contraceptives. May increase serum levels of CYP3A4 substrates e.g. digoxin, oral anticoagulants, sildenafil, tacrolimus. Potentially Fatal: May potentiate and prolong sedative and hypnotic effects of midazolam and triazolam. Increased plasma levels and prolonged QT intervals of astemizole, cisapride, dofetilide, pimozide, quinidine and terfenadine which may lead to torsade de pointes. Increased risk of myopathy w/ HMG-CoA reductase inhibitors (e.g. lovastatin, simvastatin). Markedly increased plasma levels of nisoldipine. Increased risk of...
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