Drug International Ltd.
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Caution is advised when consuming alcohol with Aprila. Please consult your doctor.
Aprila may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing ... View More
Information regarding the use of Aprila during breastfeeding is not available. Please consult your doctor.
Aprila does not usually affect your ability to drive.
Aprila should be used with caution in patients with severe kidney disease. Dose adjustment of Aprila may be needed. Please consult your doctor.
Aprila is safe to use in patients with liver disease. No dose adjustment of Aprila is recommended.
Aprila is used in the treatment of moderate to severe plaque psoriasis which is a type of skin condition. This medicine is used when other conventional ... View More
Uses of Aprila
- Plaque psoriasis
Side effects of Aprila
How to use Aprila
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Aprila may be taken with o... View More
How Aprila works
Aprila is a phosphodiesterase 4 (PDE4) inhibitors. It works by blocking the action of certain chemical messengers that are responsible for inflammation ... View More
- Aprila is a well-tolerated medicine. Mild stomach upset may occur early during the treatment.
- Monitor your weight regularly as Aprila may cause weight loss.
- Your doctor will gradually increase the dose from day 1 to day 6 of treatment, after which it may be kept constant.
- Tell your doctor immediately if you experience new or worsened depression, suicidal thoughts, other mood changes or unexplained weight loss.
Active psoriatic arthritis, moderate to severe plaque psoriasis
To reduce risk of GI symptoms associated with initial therapy, titrate to recommended dose (30 mg PO BID) according to the dosage schedules listed above... View More
Active psoriatic arthritis, moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate. To reduce risk of gastrointes... View More
Severe renal impairment (CrCl <30 mL/min): Reduce dose to 30 mg PO qDay Mild-to-moderate renal impairment: No dosage adjustment required
Known hypersensitivity to apremilast.
Mode of Action
Apremilast is an oral small-molecule inhibitor of phosphodiesterase 4 (PDE4) specific for cyclic adenosine monophosphate (cAMP). PDE4 inhibition results... View More
Apremilast is associated with an increase in adverse reactions of depression. Before using, evaluate patient for history of depression and/or suicidal t... View More
1-10% Diarrhea (7.7-9.3%),Nausea (7.4-8.9%),Headache (4.8-5.9%),Upper respiratory tract infection (0.6-3.9%),Vomiting (0.8-3.2%),Nasopharyngitis (0.2-2... View More
Pregnancy Category Note
Pregnancy Available pharmacovigilance data use in pregnant women have not established a drug-associated risk of major birth defects, miscarriage or adv... View More
Coadministration with strong CYP inducers (eg, rifampin, carbamazepine, phenobarbital phenytoin) may occur and result in a loss of efficacy of apremilas... View More
Alternative brand for Aprila
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More