Square Pharmaceuticals PLC.
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Caution is advised when consuming alcohol with Otelast 10. Please consult your doctor.
Otelast 10 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the develop... View More
Information regarding the use of Otelast 10 during breastfeeding is not available. Please consult your doctor.
Otelast 10 does not usually affect your ability to drive.
Otelast 10 should be used with caution in patients with severe kidney disease. Dose adjustment of Otelast 10 may be needed. Please consult your doctor.
Otelast 10 is safe to use in patients with liver disease. No dose adjustment of Otelast 10 is recommended.
Otelast 10 is used in the treatment of moderate to severe plaque psoriasis which is a type of skin condition. This medicine is used when other conventio... View More
Uses of Otelast 10
- Plaque psoriasis
Side effects of Otelast 10
How to use Otelast 10
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Otelast 10 may be taken wi... View More
How Otelast 10 works
Otelast 10 is a phosphodiesterase 4 (PDE4) inhibitors. It works by blocking the action of certain chemical messengers that are responsible for inflammat... View More
- Otelast 10 is a well-tolerated medicine. Mild stomach upset may occur early during the treatment.
- Monitor your weight regularly as Otelast 10 may cause weight loss.
- Your doctor will gradually increase the dose from day 1 to day 6 of treatment, after which it may be kept constant.
- Tell your doctor immediately if you experience new or worsened depression, suicidal thoughts, other mood changes or unexplained weight loss.
Active psoriatic arthritis, moderate to severe plaque psoriasis
To reduce risk of GI symptoms associated with initial therapy, titrate to recommended dose (30 mg PO BID) according to the dosage schedules listed above... View More
Active psoriatic arthritis, moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate. To reduce risk of gastrointes... View More
Severe renal impairment (CrCl <30 mL/min): Reduce dose to 30 mg PO qDay Mild-to-moderate renal impairment: No dosage adjustment required
Known hypersensitivity to apremilast.
Mode of Action
Apremilast is an oral small-molecule inhibitor of phosphodiesterase 4 (PDE4) specific for cyclic adenosine monophosphate (cAMP). PDE4 inhibition results... View More
Apremilast is associated with an increase in adverse reactions of depression. Before using, evaluate patient for history of depression and/or suicidal t... View More
1-10% Diarrhea (7.7-9.3%),Nausea (7.4-8.9%),Headache (4.8-5.9%),Upper respiratory tract infection (0.6-3.9%),Vomiting (0.8-3.2%),Nasopharyngitis (0.2-2... View More
Pregnancy Category Note
Pregnancy Available pharmacovigilance data use in pregnant women have not established a drug-associated risk of major birth defects, miscarriage or adv... View More
Coadministration with strong CYP inducers (eg, rifampin, carbamazepine, phenobarbital phenytoin) may occur and result in a loss of efficacy of apremilas... View More
Alternative brand for Otelast 10
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More