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Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Centokast 10. Please consult your doctor.
SAFE IF PRESCRIBED
Centokast 10 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Centokast 10 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Centokast 10 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Centokast 10 is safe to use in patients with kidney disease. No dose adjustment of Centokast 10 is recommended.
CAUTION
Centokast 10 should be used with caution in patients with severe liver disease. Dose adjustment of Centokast 10 may be needed. Please consult your doctor.
Limited information is available on the use of Centokast 10 in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.
Medicine Overview of Centokast 10mg Tablet
Introduction
Centokast 10 is a prescription medicine used for asthma prevention and for the treatment of allergy symptoms such as sneezing and runny nose. It reduces inflammation in the airways and make breathing easier. Centokast 10 can be taken with or without food, but take it at the same time to get the most benefit. It is advised to have it 2 hours before exercise if you have exercise-induced asthma. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you...
... Show moreUses of Centokast 10
- Asthma prevention
- Sneezing and runny nose due to allergies
Side effects of Centokast 10
Common
- Nausea
- Vomiting
- Headache
- Diarrhea
How to use Centokast 10
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Centokast 10 may be taken with or without food, but it is better to take it at a fixed time.
How Centokast 10 works
Centokast 10 works by blocking the action of leukotriene, a chemical messenger. This reduces inflammation in the airways to prevent asthma and relieve symptoms of allergies.
What if you forget to take Centokast 10?
If you miss a dose of Centokast 10, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- You have been prescribed Centokast 10 for asthma prevention and for the treatment of allergy symptoms such as sneezing and runny nose.
- It is a relatively safe medicine with very few side effects.
- Take Centokast 10 2 hours before exercising if you have exercise-induced asthma.
- It does not work right away and should not be used to relieve sudden breathing problems. Use your rescue inhaler to control sudden difficulty in breathing.
- Do not discontinue use without consulting your doctor, even if you feel better.
Brief Description
Indication
Asthma, Allergic rhinitis
Adult Dose
Oral
Chronic asthma
Adult: As film-coated tab: 10 mg once daily in the evening.
Allergic rhinitis
Adult: 10 mg once daily.
Prophylaxis of exercise-induced asthma
Adult: 10 mg at least 2 hr prior to exercise; do not take additional doses w/in 24 hr.
Elderly: No dosage adjustment needed.
Hepatic impairment: Mild to moderate: No dosage adjustment needed.
Child Dose
Asthma
Prophylaxis and maintenance treatment in patients aged >12 months
15 years: 10 mg (conventional tablet) PO once daily in evening
Exercise-Induced Bronchospasm
Prophylaxis
6-15 years: 5 mg (chewable tablet) PO 2 hours before exercise; do not take additional dose within 24 hours
>15 years: 10 mg PO 2 hours before exercise; do not take additional dose within 24 hours
If taking drug for another indication, do not take additional dose to prevent EIB
Perennial Allergic Rhinitis
15 years: 10 mg (conventional tablet) PO once daily
Seasonal Allergic Rhinitis
15 years: 10 mg (conventional tablet) PO once daily
Renal Dose
Renal impairment: No dosage adjustment needed.
Contraindication
Hypersensitivity.
Mode of Action
Montelukast is a selective leukotriene receptor antagonist that blocks the effects of cysteinyl leukotrienes in the airways.
Precaution
Not for the relief of acute bronchospasm. Not to be used as monotherapy for the prevention of exercise-induced bronchospasm. Patients in whom asthma is precipitated by aspirin or other NSAIDs should continue to avoid aspirin and NSAIDs. Do not abruptly substitute for oral or inhaled corticosteroids. Be alert for any signs of Churg-Strauss syndrome. Pregnancy and lactation. Children <6 mth.
Lactation: Unknown whether agent is excreted in breast milk, use with caution
Side Effect
>10%
Headache (18.4%; similar to placebo)
1-10%
>2%
Abdominal pain,Eczema,Influenza,Laryngitis,Pharyngitis,Viral infection,Wheezing,Dental pain,Dizziness,Dyspepsia, Dental pain (2%),Dizziness (2%),Dyspepsia (2%)Elevated liver function tests (2%),Fever (2%),Gastroenteritis (2%),Nasal congestion (2%),Otitis (2%),Rash (2%),Urticaria (2%),
>1%
Bronchitis,Cough,Sinusitis,Upper respiratory tract infection
<1%
Allergic granulomatous angiitis (Churg-Strauss syndrome; rare),Cholestatic hepatitis (rare),Aggressive behavior, altered behavior, suicidal thoughts
Potentially Fatal: Anaphylaxis, Churg-Strauss syndrome.
Interaction
Induced hepatic metabolism resulting to decreased plasma concentration w/ potent inducers of cytochrome P450 isoenzymes (e.g. phenobarbital, phenytoin, rifampicin).
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