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Square Pharmaceuticals PLC.
Generic: Imipramine Hydrochloride
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descriptionSafety Advices
Depram may cause excessive drowsiness with alcohol.
Depram may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing ... View More
Depram is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Depram may cause side effects which could affect your ability to drive. As Depram may impair your alertness or cause drowsiness or blurred vision, and t... View More
Depram should be used with caution in patients with kidney disease. Dose adjustment of Depram may be needed. Please consult your doctor.
Depram should be used with caution in patients with liver disease. Dose adjustment of Depram may be needed. Please consult your doctor. Regular monitori... View More
descriptionMedical Overview


Depram is known as a tricyclic antidepressant. It is used to treat depression and bedwetting in children of age 6 years and above. It is also effective ... View More

Uses of Depram

  • Depression
  • Bed-wetting

Side effects of Depram

  • Increased heart rate
  • Blurred vision
  • Dryness in mouth
  • Difficulty in urination
  • Constipation
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)

How to use Depram

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Depram may be taken with o... View More

How Depram works

Depram is a tricyclic antidepressant. It increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.... View More

What if you forget to take Depram?

If you miss a dose of Depram, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your re... View More

quick tipsQuick Tips
  • Depram is used for the treatment of depression and bedwetting in children.
  • The main dose should be taken at night as this medicine may produce drowsiness or sleepiness.
  • You may be asked for regular blood tests to monitor the blood cell count or level of sodium and sugar in the blood.
  • Inform your doctor if you notice behavioral changes, mood changes and suicidal thoughts while taking this medicine.
  • Do not drive or do anything that requires concentration until you know how this medicine affects you.
  • Do not stop taking the medication suddenly without talking to your doctor.
descriptionBrief Description


Depression, Nocturnal enuresis


May be taken with or without food.

Adult Dose

Oral Depression Adult: Initially, 75 mg in divided doses, may gradually increase to 150-200 mg daily as necessary. Max: 300 mg/day. May give in divide... View More

Child Dose

Oral Nocturnal enuresis Child: 6-7 yr 20-25 kg: 25 mg; 8-11 yr 25-35 kg: 25-50 mg; >11yr 35-54 kg: 50-75 mg. Doses are given just before bedtime... View More


Any degree of heart block or cardiac arrhythmias, recent MI, porphyria, narrow-angle glaucoma, urine retention, mania. Severe hepatic impairment. Childn... View More

Mode of Action

Imipramine is believed to increase the synaptic concentration of serotonin and/or norepinephrine in the CNS by inhibition of their reuptake by the presy... View More


Imipramine should be used cautiously and with close physician supervision in people, especially the elderly, who have benign prostatic hypertrophy, urin... View More

Side Effect

Orthostatic hypotension, HTN, tachycardia, palpitation, MI, arrhythmias, heart block, ECG changes, precipitation of CHF, stroke; confusional states (esp... View More


Increased plasma levels and effects with quinidine, cimetidine, SSRIs, propafenone, flecainide. Reduced plasma levels with barbiturates, phenytoin. May ... View More

Alternative brand for Depram
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More

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