The aldosterone (supine) test measures the level of aldosterone, a hormone produced by the adrenal glands, in the blood. This test is typically done while the patient is lying down (supine position), as aldosterone levels can vary based on body posture. Aldosterone plays a key role in regulating sodium, potassium, and blood pressure.

Risk Assessment:

• Minimal risk: The procedure involves a standard blood draw. Risks include slight discomfort, bruising, or infection at the puncture site.
• For individuals with specific medical conditions (e.g., bleeding disorders), special care may be needed during the draw.

Baseline Aldosterone Levels: Typically measured in ng/dL (nanograms per deciliter). Normal ranges vary but are generally around 3-35 ng/dL.

Baseline Renin Levels: Usually measured in ng/mL/hour (nanograms per milliliter per hour). Normal ranges vary but are generally around 0.2-2.3 ng/mL/hour.

Suppressed Aldosterone Levels: There isn't a strict cutoff value for suppressed aldosterone levels, but a significant decrease from baseline is expected in a normal response.

High Aldosterone, Low Renin: This pattern suggests primary hyperaldosteronism, also known as Conn's syndrome. It indicates excessive production of aldosterone by the adrenal glands, often due to an adrenal tumor (aldosterone-producing adenoma) or bilateral adrenal hyperplasia.

High Aldosterone, High Renin: This pattern may indicate secondary hyperaldosteronism, which can be caused by conditions such as renal artery stenosis, congestive heart failure, or cirrhosis. In secondary hyperaldosteronism, aldosterone production is stimulated by factors other than primary adrenal gland abnormalities.

Low Aldosterone, Low Renin: This pattern is less common but may indicate adrenal insufficiency, Addison's disease, or other conditions where aldosterone production is decreased.

Low Aldosterone, High Renin: This pattern can occur in conditions such as volume depletion, renal artery stenosis, or certain medications that affect renin-angiotensin-aldosterone system (RAAS) activity. It suggests decreased aldosterone production with compensatory increased renin production.

The Aldosterone Supine test typically requires a blood sample.