Overview:

Alpha-1 acid glycoprotein (AGP), also known as orosomucoid, is a glycoprotein produced primarily in the liver. It plays a role in the acute-phase response to inflammation and infection. The AGP test measures the concentration of AGP in the blood, often used to assess inflammation, infection, and certain medical conditions.

Risk Assessment: The test itself carries minimal risk. Blood collection typically involves a venipuncture (inserting a needle into a vein), which could cause:

• Bruising
• Bleeding
• Infection at the needle site

In certain rare cases, individuals with very thin veins or blood clotting disorders might have a slightly increased risk of complications.

Normal Range: The reference range for AGP levels in the blood can vary slightly depending on the laboratory, but typically it is:

• Normal range: 0.5 – 1.5 g/L (or 50 – 150 mg/dL).

Interpretation:

• Increased AGP levels are associated with:
  • Acute and chronic inflammation
  • Infection
  • Autoimmune diseases (e.g., rheumatoid arthritis)
  • Malignant conditions like cancer
  • Pregnancy (as AGP levels rise naturally in the second and third trimesters)
• Decreased AGP levels can be seen in conditions like:
  • Liver disease (due to impaired production)
  • Nephrotic syndrome (a kidney disorder)
  • Severe malnutrition.

Sample Type:

• Blood sample (serum or plasma) is required for the AGP test.
  • The sample is usually collected through venipuncture.