Unveiling Health Insights with Anti SS-A and SS-B Antibody Testing
SSA or Ro is composed of protein antigens of 52 kDa and 60 kDa combined with cytoplasmic RNA species. SSA antibodies occur in patients with several different connective tissue diseases including Sjogren syndrome, an autoimmune disease that involves primarily the salivary and lachrymal glands (up to 90% of cases); systemic lupus erythematosus (SLE) (40%-60% of cases); and rheumatoid arthritis.
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How our test process works!
Overview
The Anti-SS-A (Ro) test detects antibodies against SS-A (Ro) proteins, which are associated with autoimmune diseases such as Sjögren’s syndrome and systemic lupus erythematosus (SLE). It is often part of an ENA (extractable nuclear antigen) panel.
Risk Assessment
- High Risk: Presence of Anti-SS-A antibodies indicates a higher likelihood of autoimmune disorders, particularly:
- Sjögren's syndrome
- Systemic lupus erythematosus (SLE)
- Neonatal lupus (if maternal antibodies are present)
- Congenital heart block in fetuses of pregnant women with anti-SS-A antibodies.
- Can also appear in other autoimmune conditions and some infections.
Normal Range
- Negative: Typically reported as <1.0 AI (antibody index) or as "Negative."
- Positive: Reported as >1.0 AI or above the lab-specific cutoff value.
- Ranges may vary depending on laboratory reference standards.
Interpretation
- Negative Result: Anti-SS-A antibodies are absent, less likely linked to autoimmune diseases.
- Positive Result: Suggestive of:
- Sjögren’s syndrome (highly specific when combined with symptoms)
- SLE (can occur in ~30-50% of SLE patients)
- Neonatal lupus risk in maternal cases.
Further correlation with clinical symptoms and other tests (like Anti-SS-B, ANA test) is crucial.
Sample Type
- Serum: Blood sample collected via venipuncture.
- No special preparation is typically required.
Frequently Asked Question
Anti-SS-A
Unveiling Health Insights with Anti SS-A and SS-B Antibody Testing
SSA or Ro is composed of protein antigens of 52 kDa and 60 kDa combined with cytoplasmic RNA species. SSA antibodies occur in patients with several different connective tissue diseases including Sjogren syndrome, an autoimmune disease that involves primarily the salivary and lachrymal glands (up to 90% of cases); systemic lupus erythematosus (SLE) (40%-60% of cases); and rheumatoid arthritis.
Covid Safety
Assured
Free Report
Counselling