Ceruloplasmin is a copper-binding alpha-2 globulin synthesized in the liver. It plays a role in copper transport and iron metabolism. This test measures the amount of ceruloplasmin in the blood to help diagnose disorders related to copper metabolism.

Risk Assessment (Indications for Testing)

• Neurological or psychiatric symptoms with hepatic signs

• Kayser-Fleischer rings (suggestive of Wilson’s disease)

• Hepatosplenomegaly of unknown origin

• Family history of Wilson’s disease

• Hemolytic anemia with elevated liver enzymes

• Low serum copper levels with suggestive symptoms

• Children with unexplained liver dysfunction

• Adult:
  20–35 mg/dL (or 200–350 mg/L, depending on the lab)

• Children (variable by age): slightly lower values in infants and younger children.

Interpretation

• Low ceruloplasmin levels may indicate:
  • Wilson's disease (a genetic disorder that leads to copper buildup in the body)
  • Nephrotic syndrome (kidney disorder)
  • Malnutrition or liver disease
• High ceruloplasmin levels can be seen in:
  • Inflammatory conditions
  • Pregnancy (due to increased levels of certain proteins)
  • Iron deficiency anemia

A low level of ceruloplasmin is a key diagnostic marker for Wilson’s disease, while elevated levels can reflect inflammation or other health issues.

Sample Type

The test requires a blood sample, typically drawn from a vein in the arm. The sample is then analyzed in a laboratory to measure ceruloplasmin levels.