The DHEA-SO4 (Dehydroepiandrosterone sulfate) test measures the level of DHEA-SO4 in the blood. DHEA-SO4 is an androgen hormone primarily produced by the adrenal glands and serves as a precursor for male and female sex hormones like testosterone and estrogen.

Clinical Uses:

• Evaluate adrenal gland function
• Diagnose adrenal disorders (e.g., tumors, hyperplasia)
• Assess causes of virilization (excess male characteristics)
• Investigate symptoms like hirsutism, infertility, or irregular periods in women
• Evaluate precocious puberty or delayed puberty in children.

Risk Assessment and Considerations:

• No major risks; standard blood draw procedures apply (minor pain, bruising).
• Results may be influenced by:
  • Hormone supplements (testosterone, estrogen, DHEA)
  • Medications (e.g., glucocorticoids)
  • Chronic illness or stress

For accurate results, inform your doctor of any medications or supplements you take.

Normal Range:

Ranges can vary slightly depending on the lab but are generally:

• Men: 280 - 640 µg/dL

• Women (premenopausal): 35 - 430 µg/dL

• Women (postmenopausal): 20 - 220 µg/dL

• Children: Levels are lower and increase with age during puberty.

Note: Age, sex, and testing methods may influence results.

Interpretation of Results:

1. High DHEA-SO4 levels

   • Adrenal hyperplasia (overactive adrenal glands)
   • Adrenal tumors or cancers
   • Polycystic Ovary Syndrome (PCOS)
   • Cushing's syndrome
   • Early puberty in children

2. Low DHEA-SO4 levels

   • Adrenal insufficiency (e.g., Addison's disease)
   • Aging (natural decline with age)
   • Hypopituitarism (underactive pituitary gland).

Sample Type: 

Blood sample drawn from a vein (serum).