Overview

The LKM (Liver-Kidney Microsomal) Antibody Test is a blood test used to detect anti-LKM antibodies, which are associated with autoimmune hepatitis type 2 (AIH-2). These antibodies target liver and kidney microsomes, leading to liver inflammation and damage.

Risk Assessment

The LKM test is primarily used to assess the risk of:
Autoimmune Hepatitis Type 2 (AIH-2) – A rare but severe liver disease.
Chronic Liver Disease – Differentiates autoimmune hepatitis from viral hepatitis or drug-induced hepatitis.
Overlap Syndromes – Helps distinguish AIH-2 from other autoimmune conditions like primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC).
Liver Dysfunction – Assists in diagnosing the cause of elevated liver enzymes (AST, ALT).

Normal Range

🔹 Negative: No detectable anti-LKM antibodies (Normal)
🔹 Positive: Detected at varying titers (≥1:40 considered significant).

Test Interpretation

✔ Positive Result → Presence of LKM antibodies suggests autoimmune hepatitis type 2.
✔ Negative Result → Absence of LKM antibodies; AIH-2 is unlikely.

🔎 Further Evaluation If Positive:

• Liver Function Tests (LFTs) (AST, ALT, ALP, Bilirubin)
• Other Autoantibodies (ANA, SMA, SLA/LP)
• Liver Biopsy for confirmation.

Sample Type

Sample Required: Serum (Blood sample drawn from a vein)
Processing Time: Results available within 2-5 days.