Explanation of why the test is performed, including its role in diagnosing conditions like antiphospholipid syndrome (APS).
The Lupus Anticoagulants (LA) test is a blood test that detects antibodies that interfere with the blood clotting process. It is often used to evaluate unexplained blood clotting or recurrent miscarriages and is associated with autoimmune conditions like antiphospholipid syndrome (APS).
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How our test process works!
The Lupus Anticoagulants (LA) test is used to detect the presence of lupus anticoagulants—antibodies that interfere with phospholipid-dependent coagulation processes. Despite the name, these antibodies increase the risk of clotting (thrombosis) rather than bleeding.
Risk Assessment
- Associated with an increased risk of thrombosis, including deep vein thrombosis (DVT), pulmonary embolism (PE), and recurrent miscarriages.
- Commonly found in individuals with antiphospholipid syndrome (APS), autoimmune disorders (e.g., systemic lupus erythematosus), or secondary to infections and medications.
Normal Range
- Normal result: Negative for lupus anticoagulants.
- Results are often reported as:
- Negative (no LA detected)
- Borderline (needs further testing)
- Positive (LA detected, requires interpretation).
Interpretation
- Negative: No significant lupus anticoagulants detected.
- Positive: Lupus anticoagulants present, indicating an increased risk of clotting. Requires correlation with clinical symptoms and other lab findings.
- False positives can occur, and testing must follow a multi-step process:
- Prolonged clotting time (e.g., aPTT).
- Mixing study to confirm inhibition.
- Confirmation using phospholipid-sensitive assays (e.g., DRVVT).
Sample Type
- Sample: Citrated plasma (collected in a light blue-top tube).
- Requirement:
- 3.2% sodium citrate anticoagulated blood.
- Proper handling and timely processing are essential to avoid false results.
Frequently Asked Question
Lupus Anticoagulants
Explanation of why the test is performed, including its role in diagnosing conditions like antiphospholipid syndrome (APS).
The Lupus Anticoagulants (LA) test is a blood test that detects antibodies that interfere with the blood clotting process. It is often used to evaluate unexplained blood clotting or recurrent miscarriages and is associated with autoimmune conditions like antiphospholipid syndrome (APS).
Covid Safety
Assured
Free Report
Counselling