An E2 (Estradiol) test measures the amount of the hormone estradiol, a hormone produced by both males and females. Though estradiol is primarily a female sex hormone that is produced by the ovaries, breasts, and adrenal glands, males also produce it but in small amounts. You may need this test to check for menstrual problems, early or delayed puberty, menopause symptoms, or certain types of cancer such as breast cancer. Estradiol, also known as E2, is the primary and most potent form of estrogen in your body during your reproductive years. It plays a vital role in the development and functioning of the female reproductive system.

menstrual problems, early or delayed puberty, menopause symptoms, or certain types of cancer such as breast cancer.

Normal Range of Estradiol (E2)

• Women (premenopausal): 15 to 350 pg/mL (depending on the phase of the menstrual cycle)
• Women (postmenopausal): Less than 10 to 50 pg/mL
• Men: 10 to 40 pg/mL
• Children (before puberty): Less than 10 pg/mL

These ranges can vary slightly depending on the laboratory and the method used.

- **Sample Required:** A blood sample is drawn from a vein in the arm.
- **Preparation:** No special preparation is usually required, although the timing of the test might be important in women, depending on the phase of the menstrual cycle.