A diagnostic test for detecting autoimmune kidney disease associated with membranous nephropathy
The Phospholipase A2 Receptor Antibody (PLAZR) test is a blood test used to detect antibodies against the Phospholipase A2 receptor, a protein found on the surface of kidney cells. These antibodies are commonly associated with membranous nephropathy, a type of kidney disease that leads to protein leakage in the urine and can result in kidney damage. Elevated levels of PLA2R antibodies are often found in patients with primary membranous nephropathy, making this test useful in diagnosing the condition and distinguishing it from secondary forms of the disease. The test can help in determining the cause of kidney issues and guiding treatment decisions.
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How our test process works!
The Phospholipase A2 Receptor (PLA2R) Antibody Test is used to detect autoantibodies against the PLA2R protein, which are commonly associated with primary membranous nephropathy (PMN)—a kidney disease characterized by the thickening of glomerular capillary walls due to immune deposits. This test helps in diagnosing, monitoring disease activity, and predicting relapse in PMN.
Positive PLA2R Antibodies: Strongly suggest primary membranous nephropathy.
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- Common risk factors include:
- Autoimmune diseases
- Genetic predisposition
- Environmental triggers
- Common risk factors include:
Negative PLA2R Antibodies: May indicate secondary membranous nephropathy (e.g., due to infections, malignancies, or drugs) or inactive/treated disease.
Negative: < 20 RU/mL (relative units per milliliter).
Borderline: 20–40 RU/mL.
Positive: > 40 RU/mL.
Negative:
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- Likely excludes primary membranous nephropathy.
- May indicate remission or secondary causes.
Positive:
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- Confirms active primary membranous nephropathy.
- Levels correlate with disease activity and response to treatment.
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Decreasing Levels: Suggest response to therapy.
Increasing Levels: Suggest relapse or ongoing disease activity.
Specimen: Blood (Serum)
Collection: Requires a blood draw from a vein, usually in the arm.
Frequently Asked Question
PHOSPHOLIPASE A2 RECEPTOR (PLA2R) ANTIBODY QUANTITATIVE
A diagnostic test for detecting autoimmune kidney disease associated with membranous nephropathy
The Phospholipase A2 Receptor Antibody (PLAZR) test is a blood test used to detect antibodies against the Phospholipase A2 receptor, a protein found on the surface of kidney cells. These antibodies are commonly associated with membranous nephropathy, a type of kidney disease that leads to protein leakage in the urine and can result in kidney damage. Elevated levels of PLA2R antibodies are often found in patients with primary membranous nephropathy, making this test useful in diagnosing the condition and distinguishing it from secondary forms of the disease. The test can help in determining the cause of kidney issues and guiding treatment decisions.
Covid Safety
Assured
Free Report
Counselling