Sex Hormone-Binding Globulin (SHBG) is a protein produced mainly by the liver that binds to sex hormones, particularly testosterone, dihydrotestosterone (DHT), and estrogen, regulating their bioavailability in the bloodstream.The SHBG Test Done to:

1. Evaluate testosterone levels (especially when total testosterone doesn't align with symptoms).
2. Diagnose or assess conditions like:
   • Hypogonadism
   • Polycystic Ovary Syndrome (PCOS)
   • Androgen deficiency
   • Hormonal imbalances.

Risk Assessment

• Low SHBG Levels may indicate:

  • Obesity
  • Type 2 diabetes
  • Hypothyroidism
  • Excess androgen levels
  • Metabolic syndrome

• High SHBG Levels may indicate:

  • Liver disease
  • Hyperthyroidism
  • Estrogen dominance (e.g., during pregnancy or due to certain medications)
  • Reduced testosterone bioavailability.

Normal Range

SHBG levels depend on age, sex, and lab methods:

• Men: 10–57 nmol/L
• Women (pre-menopausal): 30–120 nmol/L
• Women (post-menopausal): 20–130 nmol/L

Interpretation

• Low SHBG → Excessive free testosterone or hormonal imbalance.
• High SHBG → Low free testosterone or estrogen imbalance.

It is often interpreted alongside free testosterone or total testosterone levels to better understand hormone activity.

Sample Type

• Blood Sample (Venous blood draw).