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Locol 40
Popular Pharmaceuticals Ltd.
Generic: Atorvastatin
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Locol 40. Please consult your doctor.
UNSAFE
Locol 40 is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
UNSAFE
Locol 40 is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
SAFE
Locol 40 does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Locol 40 is safe to use in patients with kidney disease. No dose adjustment of Locol 40 is recommended.
However, inform your doctor if you have any underlying kidney disease.
CAUTION
Locol 40 should be used with caution in patients with liver disease. Dose adjustment of Locol 40 may be needed. Please consult your doctor.
Use of Locol 40 is not recommended in patients with severe liver disease and active liver disease.
Medicine Overview of Locol 40mg Tablet
Introduction
Locol 40 belongs to a group of medicines called statins. It is used to lower cholesterol and to reduce the risk of heart disease. Cholesterol is a fatty substance that builds up in your blood vessels and causes narrowing, which may lead to a heart attack or stroke. Locol 40 is a widely prescribed medicine and is regarded as safe for long-term use when taken as per doctor's advice. It can be taken with a meal or on an empty stomach. You can take it at any time of the day but try to take it at the same time...
... Show moreUses of Locol 40
- High cholesterol
- Prevention of heart attack
Side effects of Locol 40
Common
- Constipation
- Headache
- Muscle pain
How to use Locol 40
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Locol 40 may be taken with or without food, but it is better to take it at a fixed time.
How Locol 40 works
Locol 40 is a lipid-lowering medication (statin). It works by blocking an enzyme (HMG-CoA-reductase) that is required in the body to make cholesterol. It thus lowers "bad" cholesterol (LDL) and triglycerides, raising the level of "good" cholesterol (HDL).
What if you forget to take Locol 40?
If you miss a dose of Locol 40, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not take two doses within 12 hour.
Quick Tips
- In general, Locol 40 is safe. It may cause diarrhea, gas or an upset stomach. If any of these happen to you, take it with food.
- Inform your doctor if you experience fatigue, muscle weakness or muscle pain.
- Your doctor may check your liver function before starting the treatment and regularly thereafter. Inform your doctor if you notice signs of liver problems such as stomach pains, unusually dark urine or yellowing of skin or eyes.
- Inform your doctor if you have kidney disease, liver disease or diabetes before starting treatment with this medicine. If you are diabetic, monitor your blood sugar level regularly as Locol 40 may cause an increase in your blood sugar level.
- Do not take Locol 40 if you are pregnant, planning a pregnancy or breastfeeding.
Brief Description
Indication
Oral
Mixed dyslipidaemia, Heterozygous familial hypercholesterolaemia, Nonfamilial hypercholesterolaemia
Adult: Initially, 10 or 20 mg once daily, may be adjusted at 4-wk interval. May initiate 40 mg once daily in patients who require >45% reduction in LDL-cholesterol. Max: 80 mg/day.
Elderly: No dosage adjustment needed.
Administration
May increase risk of myopathy and rhabdomyolysis w/ CYP3A4 potent inhibitor (e.g. HIV or HCV protease inhibitors, itraconazole, clarithromycin), fenofibrate, colchicines, fixed combination of lopinavir/ritonavir. May decrease plasma concentration w/ CYP3A4 inducer (e.g. rifampicin, efavirenz). May significantly increase AUC and peak plasma concentration of digoxin. Increased AUC for norethindrone and ethinyl estradiol.
Potentially Fatal: Increased risk of myopathy or rhabdomyolysis w/ ciclosporin, gemfibrozil, telaprevir, tipranavir.
Adult Dose
Patients who consume substantial quantities of alcohol. History of liver disease. Patients with risk factors for myopathy or rhabdomyolysis. Hypothyroidism should be properly managed prior to starting statin therapy. Children <10 yr. Premenarcheal females.
Lactation: Because of the potential for adverse reactions in nursing infants, women taking this drug should not breastfeed; contraindicated in nursing mothers.
Renal Dose
Atorvastatin competitively inhibits HMG-CoA reductase, the enzyme that catalyses the conversion of HMG-CoA to mevalonate. This results in the induction of the LDL receptors and stimulation of LDL catabolism, leading to lowered LDL-cholesterol levels.
Contraindication
Oral
Mixed dyslipidaemia, Heterozygous familial hypercholesterolaemia, Nonfamilial hypercholesterolaemia
Child: Heterozygous familial hypercholesterolaemia: 10-17 yr 10 mg once daily, may increase at intervals of at least 4 wk to max 20 mg/day.
Mode of Action
Atorvastatin can be administered as a single dose at any time of the day, with or without food. Avoid excessive consumption (>1 L/day) of grapefruit juice.
Precaution
Primary hypercholesterolemia (heterozygous familial and nonfamilial), Mixed Dyslipidemia, Homozygous familial hypercholesterolemia, Hypertriglyceridemia, Familial hypercholesterolemia, Cardiovascular event prevention, Primary dysbetalipoproteinemia
Side Effect
Renal Insufficiency: Renal disease does not affect the plasma concentrations or LDL-C reduction of atorvastatin; thus, dosage adjustment in patients with renal dysfunction is not necessary.
Pregnancy Category Note
>10%
Diarrhea (5-14%),Nasopharyngitis (4-13%),Arthralgia (4-12%)
1-10%
Insomnia (1-5%),Urinary tract infection (4-8%),Nausea (4-7%),Dyspepsia (3-6%),Increased transaminases (2-3%),Muscle spasms (2-5%),Musculoskeletal pain (2-5%),Myalgia (3-8%),Limb pain (3-8%),Pharyngolaryngeal pain (1-4%)
Frequency Not Defined
Angina,Syncope,Dyspnea,Myopathy,Anaphylaxis,Stevens-Johnson syndrome,Myositis
Potentially Fatal: Thrombocytopenia. Rhabdomyolysis with acute renal failure.
Interaction
Hypersensitivity, active liver disease or unexplained persistent elevations of serum transaminase, porphyria, pregnancy, lactation.
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