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Safety Advices
বাংলা
English
UNSAFE
Consuming alcohol while taking M 400 may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
SAFE IF PRESCRIBED
M 400 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
CAUTION
M 400 should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
If a single dose of M 400 is used, it is recommended to hold breastfeeding for 12-24 hours to allow the removal of the drug.
UNSAFE
M 400 may cause side effects which could affect your ability to drive.
M 400 may make you feel sleepy, dizzy, confused. You may have hallucinations, fits (convulsions) or temporary eyesight problems (such as blurred or double vision) affecting your ability to drive.
SAFE IF PRESCRIBED
M 400 is safe to use in patients with kidney disease. No dose adjustment of M 400 is recommended.
Patients undergoing kidney dialysis should take this medicine after the dialysis treatment.
CAUTION
M 400 should be used with caution in patients with liver disease. Dose adjustment of M 400 may be needed. Please consult your doctor.
Medicine Overview of M 400mg Tablet
Introduction
M 400 is an antibiotic medicine that helps your body fight infections caused by bacteria and parasites. It is used to treat infections of the liver, stomach, intestines, vagina, brain, heart, lungs, bones and skin. M 400 helps prevent an infection after surgery. It is also used in the treatment of dental infections, leg ulcers and pressure sores. This medicine is best taken after eating some food. It should be taken at the same time each day to get the most benefit. The amount you are advised will depend on what you are being treated for and how bad it...
... Show moreUses of M 400
- Bacterial infections
- Parasitic infections
Side effects of M 400
Common
- Headache
- Dryness in mouth
- Nausea
- Metallic taste
How to use M 400
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. M 400 is to be taken with food.
How M 400 works
M 400 is an antibiotic. It kills the bacteria and other microorganisms that cause infections by damaging their DNA.
What if you forget to take M 400?
If you miss a dose of M 400, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- M 400 treats infections caused by bacteria and parasites.
- It may cause side effects like nausea, stomach upset, and a metallic taste in the mouth.
- M 400 used in a high dose or for a prolonged time increases the risk of side effects such as nerve damage. Take it only as prescribed by your doctor.
- Do not drink alcohol during or for 2-3 days after treatment with this medicine. You may develop nausea, vomiting, flushing and headache.
- Inform your doctor if you have liver disease. Your dose may need to be adjusted in severe liver disease.
Brief Description
Indication
Pneumonia, Giardiasis, Peptic ulcer disease, Peritonitis, H. pylori infection, Rosacea, Septicemia, Endometritis, Aspiration pneumonia, Lung abscess, Empyema, Bone and Joint Infections, Surgical Prophylaxis, Amoebiasis, Bacterial vaginosis, Balantidiasis, Blastocystis hominis infection, Trichomoniasis, Acute dental infections, Acute necrotising ulcerative gingivitis, Anaerobic bacterial infections, Antibiotic-associated colitis, Fungating tumours, Leg ulcers and pressure sores, Diverticulitis, Diabetic foot ulcer, Meningitis and brain abscesses, endocarditis
Administration
Susp: Should be taken on an empty stomach. Take at least 1 hr before meals. Tab: Should be taken with food. Reconstitution: Add 4.4 mL of sterile or bacteriostatic water for inj, NaCl 0.9% inj, or bacteriostatic NaCl inj to a vial labeled as containing metronidazole 500 mg. The resultant soln contains approx 100 mg/mL and must be further diluted w/ NaCl 0.9% inj, dextrose 5% inj, or lactated Ringer's inj to a concentration of 8 mg/mL or less. The reconstituted and diluted soln must then be neutralised by adding approx 5 mEq of Na bicarbonate inj for each 500...
... Show moreAdult Dose
Oral Child: PO 30–50 mg/kg/day q8h Amoebiasis Adult: 800 mg tid for 5 days (intestinal infection); 5-10 days (extra-intestinal infection). Max: 2.4 g/day. Trichomoniasis Adult: 2 g as a single dose, 200 mg tid for 7 days or 400 mg bid for 5-7 days. Sexual partners should also be treated. Repeat treatment 4-6 wk between courses as necessary. Giardiasis Adult: 2 g once daily for 3 days, 400 mg tid for 5 days or 500 mg bid for 7-10 days. Bacterial vaginosis Adult: 2 g as a single dose or 400 mg bid for 5-7 days. Acute necrotising ulcerative gingivitis...
... Show moreChild Dose
Oral Amoebiasis Child: 1-3 yr 100-200 mg tid; >3-7 yr 100-200 mg 4 times daily; >7-10 yr 200-400 mg tid. Doses are given for 5-10 days. Trichomoniasis Child: 1-10 yr 40 mg/kg as a single dose or 15-30 mg/kg daily in 2-3 divided doses for 7 days. Max: 2 g/dose. Giardiasis Child: 1-3 yr 500 mg once daily; >3-7 yr 600-800 mg once daily; >7-10 yr 1 g once daily. Doses are given for 3 days. Acute necrotising ulcerative gingivitis Child: 1-3 yr 50 mg tid; >3-7 yr 100 mg bid; >7-10 yr 100 mg tid. Doses are given for...
... Show moreContraindication
History of hypersensitivity to metronidazole or other nitroimidazole derivatives. Pregnancy (1st trimester) and lactation.
Mode of Action
Metronidazole is converted to reduction products that interact w/ DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms. It is active against most anaerobic protozoa, some gm+ve, gm-ve and facultative anaerobes.
Precaution
Patients with CNS diseases; discontinue IV therapy if abnormal neurologic symptoms occur. History of seizure disorder. Evidence or a history of blood dyscrasias; perform total and differential leukocyte counts before and after treatment. Severe hepatic impairment; monitor plasma levels. Predisposition to oedema (inj contains sodium). Prolonged use may result in fungal or bacterial superinfection.
Excreted in human milk; not recommended
Side Effect
GI disturbances e.g. nausea, unpleasant metallic taste, vomiting, diarrhoea or constipation. Furred tongue, glossitis, and stomatitis due to overgrowth of Candida. Rarely, antibiotic-associated colitis. Weakness, dizziness, ataxia, headache, drowsiness, insomnia, changes in mood or mental state. Numbness or tingling in the extremities, epileptiform seizures (high doses or prolonged treatment). Transient leucopenia and thrombocytopenia. Hypersensitivity reactions. Urethral discomfort and darkening of urine. Raised liver enzyme values, cholestatic hepatitis, jaundice. Thrombophlebitis (IV).
Potentially Fatal: Anaphylaxis.
Interaction
Concurrent use w/ disulfiram may produce psychotic reactions. May potentiate the effect of oral anticoagulants. May increase risk of lithium toxicity. May reduce the renal clearance resulting to increased toxicity of 5-fluorouracil. May increase serum levels of ciclosporin. May increase plasma levels of busulfan resulting to severe busulfan toxicity. Enhanced metabolism w/ phenobarbital and phenytoin resulting to decreased serum concentrations.
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