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Salazine 500
Opsonin Pharma Limited
Generic: Sulfasalazine
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Salazine 500.
SAFE IF PRESCRIBED
Salazine 500 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
CONSULT YOUR DOCTOR
Salazine 500 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
SAFE
Salazine 500 does not usually affect your ability to drive.
CAUTION
Salazine 500 should be used with caution in patients with kidney disease. Dose adjustment of Salazine 500 may be needed. Please consult your doctor.
Regular monitoring of kidney function tests is advisable while you are taking this medicine.
UNSAFE
Salazine 500 is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
Medicine Overview of Salazine 500mg Tablet
Introduction
Salazine 500 is a medicine used to treat various inflammatory conditions of the joints (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis), skin (psoriasis), and bowel (ulcerative colitis, Crohn’s disease). Salazine 500 is to be taken with food. This will help you prevent an upset stomach. You should take it regularly and at the same time each day to get the maximum benefit from it. Keep taking it as recommended by your doctor and complete the dose even if you feel better. Taking it with plenty of water can help you avoid kidney problems such as kidney stones. Using this medicine may...
... Show moreUses of Salazine 500
- Rheumatoid arthritis
- Ulcerative colitis
- Crohn’s disease
- Ankylosing spondylitis
Side effects of Salazine 500
Common
- Diarrhea
- Gastrointestinal discomfort
- Headache
- Loss of appetite
- Nausea
- Oligospermia (low sperm count)
- Vomiting
- Weight loss
How to use Salazine 500
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Salazine 500 is to be taken with food.
How Salazine 500 works
Salazine 500 is a Disease Modifying Anti-Rheumatoid Drug (DMARD). It works by suppressing the overactivity of the immune system in autoimmune diseases and blocks the chemical messengers that cause inflammation (swelling).
What if you forget to take Salazine 500?
If you miss a dose of Salazine 500, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Take it with food to avoid an upset stomach.
- It may take 6-8 weeks for Sazo 500 Tablet DR to work. Keep taking it as prescribed.
- Drink plenty of fluids while taking Sazo 500 Tablet DR in order to avoid kidney problems such as kidney stones.
- It may cause a deficiency of folic acid. Take the supplements as suggested by the doctor.
- Do not take Sazo 500 Tablet DR if you are allergic to sulfa drugs or aspirin.
- It may discolour your skin, urine, saliva and tears an orange/yellow colour. This is normal and not harmful.
- Regular blood tests to monitor your liver function, kidney function, and the levels of your blood components are required while taking this medicine.
- Do not stop taking the medication suddenly without talking to your doctor.
Brief Description
Indication
Inflammatory bowel disease, Rheumatoid arthritis
Administration
Should be taken with food. Take after meals. Ensure adequate fluid intake.
Adult Dose
Oral
Inflammatory bowel disease
Adult: Initially, 1-2 g 4 times daily until remission occurs. Maintenance: 2 g/day in divided doses.
Rheumatoid arthritis
Adult: As enteric-coated tablet: Initially, 500 mg daily for the 1st wk increased by 500 mg every wk. Max: 3 g daily in 2-4 divided doses.
Rectal
Inflammatory bowel disease
Adult: As suppository: 0.5-1 g in the morning and night, either alone or as an adjunct to oral treatment.
Hepatic impairment: Avoid use.
Child Dose
Oral
Inflammatory bowel disease
Child: >2 yr: 40-60 mg/kg/day in divided doses. Maintenance: 20-30 mg/kg/day in divided doses.
Rheumatoid arthritis
Child: For polyarticular juvenile rheumatoid arthritis: >6 yr: As enteric-coated tablet: 30-50 mg/kg/day in 2 divided doses. Begin treatment with 1/4 to 2/3 of expected maintenance dose and increase wkly to reach maintenance dose in 1 mth. Max: 2 g daily.
Rectal
Inflammatory bowel disease
Child: As suppository (may be given as divided doses): 5-8 yr: 500 mg bid; 8-12 yr: 500 mg in the morning and 1 g at night; 12-18 yr: 1 g bid.
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
10-30ml/min Admin twice daily.
<10ml/min Admin once daily.
Contraindication
Hypersensitivity to sulphonamides or salicylates, porphyria, <2 yr of age, intestinal or urinary obstruction, blood dycrasias, history of leucopenia with gold therapy.
Mode of Action
Actual mechanism not determined. Sulphasalazine may have direct anti-inflammatory action in the colon. It also systemically interferes with secretion by prostaglandin synthesis inhibition.
Precaution
Hepatic/renal impairment, G6PD deficiency, allergic bronchial asthma, lactation.
Lactation: Excreted into human breast milk; caution with breastfeeding, some reports of bloody stools or diarrhea in human milk fed infants of mothers taking sulfasalazine
Side Effect
>10%
Anorexia (~33%),Headache (~33%),Nausea (~33%),Vomiting (~33%),Gastric distress (~33%),Apparently reversible oligospermia (~33%)
<1%
Skin rash,Pruritus,Urticaria,Fever,Heinz body anemia,Hemolytic anemia,Cyanosis
Potentially Fatal: Severe hypersensitivity reactions, blood dyscrasias, renal and hepatic toxicity, fibrosing alveolitis.
Pregnancy Category Note
Pregnancy category: B; D if used for prolonged periods or near term; increased potential for kernicterus in the newborn
Interaction
Plasma levels reduced by rifampicin and ethambutol. Interferes with absorption of folic acid. Additive leucopaenia with gold therapy for rheumatoid arthritis. Increased haematological toxicity with azathioprine. Reduced serum levels of digoxin.
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