Medicine Overview of Neokit 20mg+400mg+500mg Tablet & Capsule
বাংলা
English
Indication
H-pylori infection.
Adult Dose
Oral
H.pylori infection
Adult: As triple therapy: Omeprazole 20 mg combined w/ clarithromycin 250 mg and metronidazole 400 mg bid
Each kit twice daily for 7-14 days.
Contraindication
Known hypersensitivity to any of its component.
Mode of Action
Omeprazole is a substituted benzimidazole gastric antisecretory agent and is also known as PPI. It blocks the final step in gastric acid secretion by specific inhibition of H+/K+ ATPase enzyme system present on the secretory surface of the gastric parietal cell. Both basal and stimulated acid are inhibited. Metronidazole is converted to reduction products that interact w/ DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms. It is active against most anaerobic protozoa, some gm+ve, gm-ve and facultative anaerobes. Clarithromycin inhibits protein synthesis in susceptible organisms by...
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Precaution
Serious and occasional hypersensitivity reactions have been reported in patients on amoxycillin therapy. Elderly patients may suffer from hepatic and renal impairment.
Omeprazole: Increased risk of hypomagnesaemia w/ diuretics. May increase INR and prothrombin time w/ warfarin. Increased risk of digoxin-induced cardiotoxic effects. May increase plasma concentration benzodiazepines (e.g. diazepam), clarithromycin and methotrexate. Decreased absorption of itraconazole, ketoconazole, posaconazole, dasatinib, iron salts. May prolong elimination of diazepam, cilostazol, phenytoin and ciclosporin. May reduce the antiplatelet effect of clopidogrel. Potentially Fatal: May decrease plasma concentrations and pharmacological effects of rilpivirine, nelfinavir and atazanavir. Metronidazole: Concurrent use w/ disulfiram may produce psychotic reactions. May potentiate the effect of oral anticoagulants. May increase risk of lithium toxicity. May reduce the renal clearance resulting to increased...
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