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Amitriptyline
Popular Pharmaceuticals Ltd.
Generic: Amitriptyline Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Amitriptyline.
CONSULT YOUR DOCTOR
Amitriptyline may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Amitriptyline is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Amitriptyline may cause side effects which could affect your ability to drive.
Amitriptyline may impair your alertness which may affect your ability to drive.
SAFE IF PRESCRIBED
Amitriptyline is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Amitriptyline may not be needed in these patients. Please consult your doctor.
CAUTION
Amitriptyline should be used with caution in patients with liver disease. Dose adjustment of Amitriptyline may be needed. Please consult your doctor.
Use of Amitriptyline is not recommended in patients with severe liver disease.
Medicine Overview of Amitriptyline 10mg Tablet
Introduction
Amitriptyline is used in the treatment of depression. It is also used to treat and prevent chronic nerve-related (neuropathic) pain, migraine, tension-type headache and nighttime bedwetting (nocturnal enuresis) by older children (6 years and above) at different doses. Amitriptyline is known as a tricyclic antidepressant. It is normally taken before bedtime because it can make you feel sleepy. It can be taken with or without food. The dose and how often you need to take it will be decided by your doctor so that you get the right amount to control your symptoms. It may be increased gradually. This medicine...
... Show moreUses of Amitriptyline
- Depression
- Neuropathic pain
- Migraine
Side effects of Amitriptyline
Common
- Constipation
- Difficulty in urination
- Dryness in mouth
- Increased heart rate
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Weight gain
- Aggressive behavior
- Agitation
- Nasal congestion (stuffy nose)
How to use Amitriptyline
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Amitriptyline may be taken with or without food, but it is better to take it at a fixed time.
How Amitriptyline works
Amitriptyline is a tricyclic antidepressant. It works by increasing the levels of chemical messengers in the brain that help in regulating mood and treat depression. It also stops the transmission of pain signals from nerves to the brain thereby relieving neuropathic pain (pain from damaged nerves).
What if you forget to take Amitriptyline?
If you miss a dose of Amitriptyline, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- It may take 4 to 6 weeks for Amitriptyline to start working. Keep taking it as prescribed.
- It may cause sleepiness. Take it at bedtime and do not drive or do anything requiring concentration until you know how it affects you.
- Avoid consuming alcohol when taking Amitriptyline as it may cause excessive sleepiness.
- Monitor your weight during the treatment as this medicine can cause weight gain and increased appetite.
- It may cause sudden drop in your blood pressure. Rise slowly if you have been sitting or lying down.
- Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
Brief Description
Indication
Adult: PO Depression Initial:50-75 mg/day; up to 150 mg/day if needed. Max: 300 mg/day in severe cases.
Neuropathic pain Initial: 10-25 mg/day at night, up to 75 mg/day if needed.
Migraine prophylaxis Initial: 10 mg/day at night. Maintenance: 50-75 mg/day at night.
Elderly: Initially, 25-50 mg/day as a single dose (at bedtime) or in divided doses.
Administration
Increased risk of serotonin syndrome w/ SSRIs, TCAs, triptans, fentanyl, lithium, tramadol. May reduce plasma levels w/ barbiturates, rifampicin and other anticonvulsants. May increase plasma levels w/ methylphenidate, cimetidine, antipsychotics, Ca channel blockers. May precipitate cardiac arrhythmias w/ thyroid hormones. May reduce antihypertensive effects of debrisoquine, guanethidine and clonidine. May increase pressor effect of epinephrine and norepinephrine. May increase the risk of ventricular arrhythmias w/ antiarrhythmics (e.g. amiodarone or quinidine), antihistamines astemizole, terfenadine, some antipsychotics (pimozide, sertindole, and thioridazine), sotalol, cisapride and halofantrine.
Potentially Fatal: Increased risk of serotonin syndrome w/ MAOIs, linezolid and methylene blue.
Adult Dose
Bipolar illness, pregnancy, lactation elderly, CVS disease, renal or liver impairment, epilepsy, thyroid dysfunction, DM. Avoid abrupt withdrawal; urinary retention, prostatic hyperplasia; chronic constipation; angle-closure glaucoma; phaeochromocytoma. Monitor for signs of clinical worsening, suicidality or behavioural changes. May increase risks associated with electro-convulsive therapy. May affect ability to drive or operate machinery.
Lactation: Distributed in breast milk; do not nurse (AAP states effect on nursing infants is unknown but may be of concern)
Renal Dose
Amitriptyline is a dibenzocycloheptadiene tricyclic antidepressant. It increases synaptic concentration of serotonin and/or norepinephrine in the CNS by blocking the neuronal reuptake of norepinephrine and serotonin.
Contraindication
PO Depression
Child: Adolescent: Initially, 25-50 mg/day as a single dose (at bedtime) or in divided doses.
Nocturnal enuresis
Child: 6-10 yr 10-20 mg/day; 11-16 yr 25-50 mg/day. All doses to be given at bedtime. Max duration: 3 mth.
Mode of Action
May be taken with or without food.
Precaution
Migraine headache, Depression, Neuropathic pain, Post-herpetic neuralgia, Nocturnal enuresis
Pregnancy Category Note
Postural hypotension, tachycardia, conduction disturbances. Dry mouth, wt gain, sour or metallic taste, stomatitis, constipation; blurring of vision, urinary retention, fatigue, dizziness, weakness, tremors, headache, confusion and delirium in elderly, sexual disturbances; peripheral neuropathy; urticaria, angioedema, sweating.
Potentially Fatal: Cardiac arrhythmias.
Interaction
Hypersensitivity, use of MAO inhibitors within the last 14 days; acute recovery phase post-MI. Concurrent usage with cisapride.
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