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Ofuran SR
Pacific Pharmaceuticals Ltd.
Generic: Nitrofurantoin
Safety Advices
বাংলা
English
UNSAFE
Consuming alcohol while taking Ofuran SR may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
SAFE IF PRESCRIBED
Ofuran SR is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
CAUTION
Ofuran SR should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
UNSAFE
Ofuran SR may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Ofuran SR should be used with caution in patients with kidney disease. Dose adjustment of Ofuran SR may be needed. Please consult your doctor.
Use of Ofuran SR is not recommended in patients with severe kidney disease, who are unable to pass urine or have high creatinine levels.
CAUTION
Ofuran SR should be used with caution in patients with liver disease. Dose adjustment of Ofuran SR may be needed. Please consult your doctor.
Use of Ofuran SR is not recommended in patients with severe liver disease and active liver disease.
Medicine Overview of Ofuran SR 100mg Tablet
Introduction
Ofuran SR is an antibiotic that fights bacteria. It is used to treat and prevent uncomplicated urinary tract infections. It works by killing the bacteria that cause such disease. But, it will not treat a viral infection. Ofuran SR should be taken in the dose and duration as advised by the doctor. You may take it with food to avoid nausea, which is a common side effect. It is better to have this medicine at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed...
... Show moreUses of Ofuran SR
- Bacterial infections of urinary tract
Side effects of Ofuran SR
Common
- Nausea
- Vomiting
- Diarrhea
How to use Ofuran SR
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ofuran SR is to be taken with food.
How Ofuran SR works
Ofuran SR is an antibiotic. It works by killing the bacteria in the urine that causes infection.
What if you forget to take Ofuran SR?
If you miss a dose of Ofuran SR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Niftas Tablet SR treats and prevents uncomplicated urinary tract infections.
- Finish the prescribed course of the medicine, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
- Take it with food to avoid nausea, which is a common side effect.
- It can turn your urine a dark yellow or brown colour. This is normal and nothing to worry about.
- Do not take it for longer or more often than prescribed by your doctor.
Brief Description
Indication
Uncomplicated UTI, Urinary Tract Infection
Administration
Should be taken with food. Take w/ or immediately after meals. Sustained release macrocrystals indicated only for patients >12 years for acute UTIs (cystitis) caused by E coli or S saprophyticus
Adult Dose
Oral
Acute uncomplicated urinary tract infections
Adult: 50-100 mg 4 times daily for 7 days or for 3 days after obtaining sterile urine.
SR preparation: 100 mg bid for 7 days or for 3 days after obtaining sterile urine.
Prophylaxis of uncomplicated urinary tract infections
Adult: 50-100 mg at bedtime for up to 12 months.
Child Dose
Urinary Tract Infection
>1 month
5-7 mg/kg/day PO divided q6hr for 7 days
UTI prophylaxis: 1-2 mg/kg PO qHS or 2 divided doses
>12 years
50-100 mg PO q6hr for 7 days or for 3 days after obtaining sterile urine
SR preparation: 100 mg PO q12hr for 7 days or for 3 days after obtaining sterile urine
Long-term prophylaxis/suppression: 50-100 mg PO at bedtime for up to 12 months
Renal Dose
Loses effectiveness in patients with CrCl <60 mL/min due to inadequate urine concentration
Monitor renal function; renally excreted; decreased renal function more likely in elderly
Contraindication
Severe renal impairment (anuria, oliguria, significantly elevated serum creatinine, CrCl <60 ml/min). Hypersensitivity to nitrofurans, G6PD deficiency, infants <3 mth. Pregnancy at term, during labour and delivery, or when the onset of labour is imminent.
Mode of Action
Nitrofurantoin interferes with cell metabolism and cell wall synthesis by inhibiting several enzyme systems including acetyl coenzyme A. It is bactericidal to most gram-positive and gram-negative urinary tract pathogens.
Precaution
Elderly. Monitor hepatic and pulmonary function during prolonged therapy. Pre-existing pulmonary, hepatic, neurological, or allergic disorders, predisposition to peripheral neuropathy e.g. renal impairment, anaemia, DM, electrolyte imbalance, debility, vitamin B deficiency. Withdraw if signs of peripheral neuropathy occur. Lactation.
Lactation: Enters breast milk; discontinue drug or do not nurse
Side Effect
Nausea, vomiting, anorexia, abdominal pain, diarrhoea; headache, drowsiness, vertigo, dizziness, nystagmus, benign intracranial hypertension; rash, urticaria, pruritus, fever, sialadenitis, angioedema, erythema multiforme, exfoliative dermatitis, pancreatitis, lupus-like syndrome, myalgia, arthralgia; acute pulmonary sensitivity reactions; megaloblastic anaemia, leucopenia, granulocytopenia or agranulocytosis, thrombocytopenia, aplastic anaemia, haemolytic anaemia (in G6PD-deficient patients); transient alopecia; brownish discolouration of urine.
Potentially Fatal: Peripheral polyneuropathy, hepatotoxicity, anaphylaxis, Stevens-Johnson syndrome, interstitial pneumonitis, pulmonary fibrosis.
Interaction
Reduced excretion with probenecid or sulfinpyrazone. Absorption reduced by magnesium trisilicate. Antagonistic effects with quinolone antibacterials. Reduced effects with carbonic anhydrase inhibitors or urinary alkalinisers.
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