12-24 Hours
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Niconic
Pacific Pharmaceuticals Ltd.
Generic: Niacin (nicotinic acid)
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Niconic. Please consult your doctor.
CONSULT YOUR DOCTOR
Niconic may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Niconic is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
SAFE
Niconic does not usually affect your ability to drive.
CONSULT YOUR DOCTOR
There is limited information available on the use of Niconic in patients with kidney disease. Please consult your doctor.
However, a cautious use of Niconic is advised in patients with kidney disease as the information available is very limited.
CAUTION
Niconic should be used with caution in patients with liver disease. Dose adjustment of Niconic may be needed. Please consult your doctor.
Use of Niconic is not recommended in patients with active liver disease.
Medicine Overview of Niconic 50mg Tablet
Introduction
Niconic is a medicine used in the treatment of conditions caused due to low levels of vitamin B3 in the body. It helps in maintenance of normal cholesterol level. It also helps in the treatment of symptoms like loss of appetite, weakness, diarrhea, skin inflammation, and mental changes. Niconic can be taken with or without food. It should be taken regularly and at the same time each day to get the most benefit from it. This medicine may be only part of a complete program of treatment that also includes making changes to your diet and taking calcium and vitamin...
... Show moreUses of Niconic
- High triglycerides
Side effects of Niconic
Common
- Itching
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Erythema (skin redness)
- Tingling
How to use Niconic
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Niconic may be taken with or without food, but it is better to take it at a fixed time.
How Niconic works
Niconic stimulates the formation of enzymes for triglyceride metabolism thereby reducing the levels of triglyceride and cholesterol in the body.
Quick Tips
- It is best known to increase "good" cholesterol (HDL). This helps prevent heart attack and stroke.
- It is better to take with food to avoid an upset stomach.
- Avoid alcohol, spicy foods, hot beverages or hot baths right before you take Niconic.
- You may feel hot and your skin colour may change after taking Niconic. Your doctor may tell you to take an aspirin 30 minutes before you take Niconic to reduce this effect.
- Notify your doctor if you have unexplained muscle pain.
Brief Description
Indication
Hyperlipidaemias, Nicotinic acid deficiency, Ischaemic events
Administration
Should be taken with food. Take at bedtime after a low-fat snack.
Adult Dose
Oral Treatment and prophylaxis of nicotinic acid deficiency Adult: For treatment of pellagra: 300-500 mg daily in divided doses. For management of Hartnup disease: 50-200 mg daily. Hyperlipidaemias Adult: Initially, 250 mg once daily in the evening. Increase dose every 4-7 days until desired LDL cholesterol and/or triglyceride level is achieved or dose of 1.5-2 g/day is reached. If hyperlipidaemia is not adequately controlled after 2 mth w/ this dose, it can be increased at 2- to 4-wk intervals to 1 g tid. Max: 6 g daily. As extended-release tab: Initially, 500 mg/day PO at bedtime initially; dose adjusted every...
... Show moreChild Dose
Oral
Treatment and prophylaxis of nicotinic acid deficiency
Child: For treatment of pellagra: 100-300 mg daily in divided doses.
Contraindication
Niacin is contraindicated in patients with a known hypersensitivity to Niacin or any component of this medication, significant or unexplained hepatic dysfunction, active peptic ulcer disease or arterial bleeding.
Mode of Action
Nicotinic acid is a derivative of vitamin B3 and is incorporated into coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are involved in multiple cellular metabolic pathways. Nicotinic acid also reduces total serum cholesterol, LDL, VLDL, and triglycerides, and increases HDL cholesterol. It appears to decrease hepatic synthesis of VLDL, however, the exact mechanisms of nicotinic acid's antilipemic effects are unknown and are unrelated to its role as a vitamin.
Precaution
Patient w/ unstable angina, acute MI, CHD, DM, gout, history of peptic ulceration. Patient who consume large amount of alcohol. Patient undergoing surgery. Renal or hepatic impairment. Pregnancy and lactation. Monitoring Parameters Monitor LFTs and blood glucose frequently.
Side Effect
Flushing, sensation of heat, faintness, pounding in the head, tingling, itching, headache, dizziness, tachycardia, palpitations, dyspnoea, sweating, chills, oedema; dryness of skin, pruritus, hyperpigmentation, rash, cramps, cough, diarrhoea, nausea and vomiting, anorexia, activation of peptic ulcer, eye disorders including cystoid macular oedema and toxic amblyopia; decreased glucose tolerance, hyperglycaemia, hyperuricaemia; abnormal LFTs, jaundice; hypophosphataemia, reduced platelet counts, prolonged prothrombin time, arrhythmias, hypersensitivity reactions including angioedema; insomnia, myalgia and hypotension.
Interaction
Increased risk of myopathy and rhabdomyolysis w/ concomitant HMG-CoA reductase inhibitors. Reduced bioavailability w/ colestyramine or colestipol. Decreased metabolic clearance w/ aspirin. May potentiate effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension.
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