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Retrovir 300
Pharmasia Ltd.
Generic: Tenofovir Disoproxil Fumarate
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Retrovir 300. Please consult your doctor.
SAFE IF PRESCRIBED
Retrovir 300 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Retrovir 300 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Retrovir 300 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Retrovir 300 should be used with caution in patients with kidney disease. Dose adjustment of Retrovir 300 may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Retrovir 300 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Retrovir 300 may not be needed in these patients. Please consult your doctor.
Medicine Overview of Retrovir 300mg Tablet
Introduction
Retrovir 300 is used to treat HIV infection and chronic hepatitis B virus (HBV) infection in combination with other anti-HIV medicines. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection. Retrovir 300 is not a cure for HIV/AIDS and only helps to decrease the amount of HIV in your body. This helps to lower your risk of getting HIV-related complications and improves your lifespan. It may also be used to prevent HIV infection in some people at high risk. This medicine is best taken with food. It...
... Show moreUses of Retrovir 300
- HIV infection
- Chronic hepatitis B virus (HBV) infection
Side effects of Retrovir 300
Common
- Rash
- Weakness
- Nausea
- Stomach pain
- Diarrhea
How to use Retrovir 300
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Retrovir 300 is to be taken with food.
How Retrovir 300 works
Retrovir 300 is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection.
What if you forget to take Retrovir 300?
If you miss a dose of Retrovir 300, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- You have been prescribed Retrovir 300 for the treatment of chronic hepatitis B virus (HBV) infection.
- In combination with other medicines, it is used for the treatment of HIV infections.
- Take it with food, as this increases the absorption of the medicine into the body.
- Retrovir 300 may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- You may still develop infections or other illnesses associated with viral infection while taking this medication.
- You can also pass on HIV or HBV to others. Don't share needles or personal items that can have blood or body fluids on them.
- During treatment and for at least six months after stopping this medicine, regular blood tests are needed to monitor your liver function, level of hepatitis B virus and blood cells in your blood.
Brief Description
Indication
HIV-1 infection, Chronic hepatitis B
Administration
May be taken with or without food. Take consistently either always w/ or always w/o food.
Adult Dose
Oral
Chronic hepatitis B; HIV infection (Indicated in combination with other antiretroviral agents for treatment of HIV-1 infection)
Adult: 300 mg once daily.
Child Dose
HIV Infection
2 years: 8 mg/kg PO qDay; not to exceed 300 mg/day
Hepatitis B Infection
12 years; 12 years; >35 kg: 300 mg PO qDay
Renal Dose
Renal impairment: Haemodialysis patients: 300 mg once every 7 days or after a cumulative total of 12 hr of dialysis.
CrCl (ml/min) Dosage Recommendation
10-29 300 mg 72-96 hrly.
30-49 300 mg 48 hrly.
Contraindication
Tenofovir is contraindicated in patients with previously demonstrated hypersensitivity to Tenofovir or any component of the product.
Mode of Action
Tenofovir disoproxil fumarate, a diester prodrug of tenofovir, is a nucleotide reverse transcriptase inhibitor. After oral absorption, tenofovir disoproxil fumarate is rapidly converted to tenofovir and then undergo subsequent phosphorylation by cellular enzymes to the active tenofovir diphosphate, which inhibits the activity of HIV-1 reverse transcriptase.
Precaution
Patient w/ hepatomegaly or other risk factors for liver disease. Renal impairment. Pregnancy. Patient Counselling This drug may cause dizziness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor renal function and serum phosphate concentrations before start of therapy, 4 wkly during the 1st wk, and then 3 mthly; hepatic function for several mth following discontinuation. Determine HIV status in all hepatitis B virus (HBV) infected patients prior to treatment.
Lactation: HIV+ women are advised not to breastfeed
Side Effect
>10%
Asthenia (11%),Diarrhea (16%),Nausea (11%),Pain (12%)
1-10%
Anorexia,Depression,Myalgia,Peripheral neuropathy,Dyspepsia,Rash,Headache,Vomiting,Flatulence,Abdominal pain,Neutropenia,Increased transaminases
Interaction
Decreased atazanavir concentration with tenofovir unless also co-administered with ritonavir. Increased serum concentration of tenofovir or co-administered drug if taken with drugs that are eliminated by active tubular secretion.
Potentially Fatal: Increased risk of renal impairment with recent or concurrent use of nephrotoxic agents (e.g. aminoglycosides, amphotericin B, foscarnet, ganciclovir, pentamidine, vancomycin, cidofovir or interleukin-2); monitor renal function wkly if unavoidable. Increased didanosine levels and thereby increasing risk of pancreatitis and peripheral neuropathy, with a high treatment failure rate with concurrent use; avoid concurrent use.
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